Protein Alignment Hel89B and Chd1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: NP_031716.2
• Gene: Chd1 / 12648
• MGIID: 88393
• Length: 1711
• Species: Mus musculus
• Alignment Length: 621
• Identity: 208/621 - (33%)
• Similarity: 309/621 - (49%)
• Gaps: 100/621 - (16%)

  Fly  1311 QLKSDPL---QARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWL---WFLNKYNL 1369
            |.|:.|.   :..|.|.| |:.....|..|..::     .:|||.||..|:|||   |.  |.|
Mouse   443 QSKTTPFKDCKVLKQRPR-FVALKKQPSYIGGHE-----GLELRDYQLNGLNWLAHSWC--KGN- 498

  Fly  1370 HGILCDDMGLGKTLQTICILAG-DHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLR 1433
            ..||.|:||||||:|||..|.. .|.|:...     |.|::.|.:....|..|::.:..|   :.
Mouse   499 SCILADEMGLGKTIQTISFLNYLFHEHQLYG-----PFLLVVPLSTLTSWQREIQTWASQ---MN 555

  Fly  1434 PLHYYGFPVGREKLRS-------DIGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNG 1491
            .:.|.|....|..:|:       ....|.|:::.:|:.:.||..|..|:::.:..:||.|.:||.
Mouse   556 AVVYLGDINSRNMIRTHEWMHPQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKND 620

  Fly  1492 KTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRD-AK 1555
            .:...|.:...|:||||:::|||:||::.|||||..|:||          ::||    |..| .:
Mouse   621 DSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMP----------EKFS----SWEDFEE 671

  Fly  1556 SSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLK 1620
            ...|.:|.|   ..:||:::.||||||||:||.|.||.|:.|.|..|:|.||.:.|:....::.|
Mouse   672 EHGKGREYG---YASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYK 733

  Fly  1621 DCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLDD 1685
             .|.| |...|.|          .....:..|:..|||..|: :..:.......|.||.:.
Mouse   734 -ALSK-GSKGSTS----------GFLNIMMELKKCCNHCYLI-KPPDNNEFYNKQEALQHL---- 781

  Fly  1686 IEHSAKLPALKQLLL---DCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLD 1747
            |..|.||..|.:||:   :.|          :|.|||.|:..||||:.:.|..|..|   :.|||
Mouse   782 IRSSGKLILLDKLLIRLRERG----------NRVLIFSQMVRMLDILAEYLKYRQFP---FQRLD 833

  Fly  1748 GSVPASQRQDIVNNFNSDPSID-VLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHR 1811
            ||:....|:..:::||::.|.| ..||:|..||||:||..||||:..:.||||..||||..||||
Mouse   834 GSIKGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHR 898

  Fly  1812 IGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAE 1876
            |||||.||:|||:|:.|:||.|:...|.|::..:.|:       |.|.|:        ||.. ..
Mouse   899 IGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVI-------QRMDTT--------GKTV-LH 947

  Fly  1877 SGSSAVQGTASGGMSMNTIIE-NLPELWSEHQYEEE 1911
            :||:....|......::.|:: ...||:.|.:.||:
Mouse   948 TGSAPSSSTPFNKEELSAILKFGAEELFKEPEGEEQ 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	185/522 (35%)
Chd1	NP_031716.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..250
		CD1_tandem_CHD1-2_like	268..352	CDD:349313
		CD2_tandem_CHD1-2_like	385..441	CDD:349308
		DEAD-like_helicase_N	458..695	CDD:475120	86/270 (32%)
		PLN03142	462..>998	CDD:215601	201/601 (33%)
		DEAH box	612..615		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1078..1119
		CDH1_2_SANT_HL1	1122..1208	CDD:477096
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1322..1407
		DUF4208	1408..1498	CDD:464035
		CHD1 helical C-terminal domain (CHCT). /evidence=ECO:0000250|UniProtKB:O14646	1409..1511
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1503..1588
		PHA03420	1591..>1691	CDD:177648
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1600..1657
		3 X 5 AA repeats of H-S-D-H-R	1629..1645
		HisXaaSer_A3	<1632..1659	CDD:439608
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1670..1711