DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hel89B and CHD4

DIOPT Version :10

Sequence 1:NP_732097.2 Gene:Hel89B / 41943 FlyBaseID:FBgn0022787 Length:1923 Species:Drosophila melanogaster
Sequence 2:NP_001264.2 Gene:CHD4 / 1108 HGNCID:1919 Length:1912 Species:Homo sapiens


Alignment Length:663 Identity:189/663 - (28%)
Similarity:303/663 - (45%) Gaps:112/663 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly  1300 VQLMPLDGKTEQLKSDPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFL 1364
            |:|..|:...|....|| ..:..|..|:||               .....|..||..|:|||.|.
Human   692 VKLRKLERPPETPTVDP-TVKYERQPEYLD---------------ATGGTLHPYQMEGLNWLRFS 740

  Fly  1365 NKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFL--- 1426
            .......||.|:||||||:||...|...:....:..    |.||..|.:...:|..|.|.:.   
Human   741 WAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKG----PFLVSAPLSTIINWEREFEMWAPDM 801

  Fly  1427 ---------DQGSVLRPLHYYGFP-----VGRE--KLRSDIGTKCNLVVASYDTVRKDIDFFSGI 1475
                     |..:::|. :.:.|.     .|::  :::.:...|.::::.||:.:..|:.....|
Human   802 YVVTYVGDKDSRAIIRE-NEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSI 865

  Fly  1476 HFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQF 1540
            .:...::||.|.:||.::|..:.:......|:|:|:|||:|||:.||:.|.:||.|......:.|
Human   866 DWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGF 930

  Fly  1541 VQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSP 1605
            ::.|:          ..|||.:     ::.||..:.|.:|||:|.||.|::|.|....:..||||
Human   931 LEEFA----------DIAKEDQ-----IKKLHDMLGPHMLRRLKADVFKNMPSKTELIVRVELSP 980

  Fly  1606 LQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELT 1670
            :|.:.|:....::. :.|:..|..:..|::           ..:..|:..||||.|....:.|..
Human   981 MQKKYYKYILTRNF-EALNARGGGNQVSLL-----------NVVMDLKKCCNHPYLFPVAAMEAP 1033

  Fly  1671 KVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLR 1735
            |:.:.: ...|:|  |..|.||..|:::|.:...|       .||.|||.|:..|||::| |.|.
Human  1034 KMPNGM-YDGSAL--IRASGKLLLLQKMLKNLKEG-------GHRVLIFSQMTKMLDLLE-DFLE 1087

  Fly  1736 RHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSID--VLLLTTMVGGLGLNLTGADTVIFVEHDWN 1798
            ..  ...|.|:||.:..:.||:.::.||: |...  ..||:|..||||:||..|||||..:.|||
Human  1088 HE--GYKYERIDGGITGNMRQEAIDRFNA-PGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWN 1149

  Fly  1799 PMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVV------------SAE 1851
            |..|:||..|||||||.|.|.:||.:||.|:||:|..:.|.|::..:.||            ..|
Human  1150 PHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRPGLGSKTGSMSKQE 1214

  Fly  1852 NASLQTMGTSQIFDLFNGGKDKGAESGSSAVQGTASGGMSM-NTIIENL----------PELWSE 1905
            ...:...||.::|      ||:..:.|....:|..|..:.. :..||.|          .||...
Human  1215 LDDILKFGTEELF------KDEATDGGGDNKEGEDSSVIHYDDKAIERLLDRNQDETEDTELQGM 1273

  Fly  1906 HQYEEEYDLGNFV 1918
            ::|...:.:..:|
Human  1274 NEYLSSFKVAQYV 1286

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hel89BNP_732097.2 HEAT repeat 5..30 CDD:293787
HEAT repeat 42..70 CDD:293787
HEAT repeat 395..420 CDD:293787
HEAT repeat 433..465 CDD:293787
HEAT repeat 475..504 CDD:293787
HEAT repeat 516..540 CDD:293787
HEAT repeat 560..589 CDD:293787
DUF3535 654..1138 CDD:463447
HepA <1342..1849 CDD:440319 163/539 (30%)
CHD4NP_001264.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..157
CHDNT 164..217 CDD:462357
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 243..360
KIKL. /evidence=ECO:0000269|PubMed:29567837 295..298
PHD1_CHD_II 372..414 CDD:277006
PHD2_CHD_II 451..493 CDD:277007
CD1_tandem_CHD3-4_like 498..576 CDD:349314
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..537
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 578..603
CD2_tandem_CHD3-4_like 619..673 CDD:349309
PLN03142 724..>1281 CDD:215601 178/608 (29%)
DEXHc_CHD4 726..957 CDD:350814 66/250 (26%)
DEAH box 873..876 2/2 (100%)
DUF1087 1302..1345 CDD:461922
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1401
CHDII_SANT-like 1381..1521 CDD:461920
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1525..1562
PRK12323 <1532..>1658 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1570..1589
Required for interaction with PCNT. /evidence=ECO:0000269|PubMed:17626165 1577..1912
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1594..1644
CHDCT2 1726..1871 CDD:462358
Blue background indicates that the domain is not in the aligned region.

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