Protein Alignment Hel89B and CHD3

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_005256484.1
• Gene: CHD3 / 1107
• HGNCID: 1918
• Length: 2115
• Species: Homo sapiens
• Alignment Length: 688
• Identity: 195/688 - (28%)
• Similarity: 308/688 - (44%)
• Gaps: 136/688 - (19%)

  Fly  1315 DPLQARKTRDREFLDYLFNPKSIPNYKVPVPISVE----------LRCYQQAGINWLWFLNKYNL 1369
            ||.|.||.:.::.......|.|.|.....|....:          |..||..|:|||.|......
Human   750 DPAQPRKYKKKKKELQGDGPPSSPTNDPTVKYETQPRFITATGGTLHMYQLEGLNWLRFSWAQGT 814

  Fly  1370 HGILCDDMGLGKTLQTICILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVE----KFL---- 1426
            ..||.|:||||||:|||..|...:....|..    |.||..|.:...:|..|.:    ||.
Human   815 DTILADEMGLGKTIQTIVFLYSLYKEGHTKG----PFLVSAPLSTIINWEREFQMWAPKFYVVTY 875

  Fly  1427 ----DQGSVLRPLHY----YGFPVGRE--KLRSDIGTKCNLVVASYDTVRKDIDFFSGIHFNYCV 1481
                |..:::|...:    .....|::  |::.:...|.::::.||:.:..|......|.:...|
Human   876 TGDKDSRAIIRENEFSFEDNAIKGGKKAFKMKREAQVKFHVLLTSYELITIDQAALGSIRWACLV 940

  Fly  1482 LDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSR 1546
            :||.|.:||.::|..:.:...|.:|:|:|:|||:|||:.||:.|.:||.|......:.|::.|:
Human   941 VDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA- 1004

  Fly  1547 PILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLY 1611
                     ..:||.:     ::.||..:.|.:|||:|.||.|::|.|....:..||||:|.:.|
Human  1005 ---------DISKEDQ-----IKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSPMQKKYY 1055

  Fly  1612 EDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQL 1676
            :....::. :.|:..|..:..|::           ..:..|:..||||.|....:.|..|:.|.
Human  1056 KYILTRNF-EALNSRGGGNQVSLL-----------NIMMDLKKCCNHPYLFPVAAMESPKLPSG- 1107

  Fly  1677 ALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSV 1741
            |....:|  |:.|.||..|:::|       :......||.|||.|:..|||::|..|   .....
Human  1108 AYEGGAL--IKSSGKLMLLQKML-------RKLKEQGHRVLIFSQMTKMLDLLEDFL---DYEGY 1160

  Fly  1742 TYLRLDGSVPASQRQDIVNNFNSDPSID--VLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQ 1804
            .|.|:||.:..:.||:.::.||: |...  ..||:|..||||:||..|||||..:.||||..|:|
Human  1161 KYERIDGGITGALRQEAIDRFNA-PGAQQFCFLLSTRAGGLGINLATADTVIIFDSDWNPHNDIQ 1224

  Fly  1805 AMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVV------SAENASLQTM----- 1858
            |..|||||||...|.:||.:||.|:||:|..:.|.|::..:.||      .|.:.|.|.:
Human  1225 AFSRAHRIGQANKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKAGSMSKQELDDILK 1289

  Fly  1859 -GTSQIFDLFNGGKDKGAES----------------GSSAVQGTASGGMSMNTII---------- 1896
             ||.::|...|.|::|..:|                ...|.:.|  ...:||..:
Human  1290 FGTEELFKDENEGENKEEDSSVIHYDNEAIARLLDRNQDATEDT--DVQNMNEYLSSFKVAQYVV 1352

  Fly  1897 -----------------ENL-PELWSE---HQYEEEYD 1913
                             ||: |:.|.:   |.||::.:
Human  1353 REEDKIEEIEREIIKQEENVDPDYWEKLLRHHYEQQQE 1390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	166/542 (31%)
CHD3	XP_005256484.1	CHDNT	207..260	CDD:462357
		PHD1_CHD_II	440..482	CDD:277006
		PHD2_CHD_II	517..559	CDD:277007
		CD1_tandem_CHD3-4_like	564..642	CDD:349314
		CD2_tandem_CHD3-4_like	687..741	CDD:349309
		PLN03142	778..>1332	CDD:215601	177/598 (30%)
		DEXHc_CHD3	795..1026	CDD:350813	70/249 (28%)
		DUF1087	<1373..1416	CDD:461922	5/18 (28%)
		CHDII_SANT-like	1437..1576	CDD:461920
		PHA03418	1578..>1727	CDD:177646
		CHDCT2	1797..1923	CDD:462358