DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hel89B and Btaf1

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_001074175.1	Gene:	Btaf1 / 107182	MGIID:	2147538	Length:	1848	Species:	Mus musculus

Alignment Length:	1976	Identity:	903/1976 - (45%)
Similarity:	1225/1976 - (61%)	Gaps:	187/1976 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SRLDRLFILLETGSTAATRQAAAKQIGEVQKLYPHELHALLNRLVGYLHSTSWETRIAAAQTVEA 67
            ||||||||||:||:|..||:|||:|:|||.||:||||:.||::::.||.||:|:|||||.|.|||
Mouse     4 SRLDRLFILLDTGTTPVTRKAAAQQLGEVVKLHPHELNNLLSKVLIYLRSTNWDTRIAAGQAVEA 68

  Fly    68 ILKQVPPWQPEFQVLPKKERCATNTATAAAAAEEDSCQSSGSNSTTASERLLSFDEFDLQQILHK 132
            |:|.||.|.|    :|:              .:::..:||..:|:|...  |:||.||:.::|..
Mouse    69 IVKNVPEWNP----VPR--------------TKQEPTESSMEDSSTTDR--LNFDRFDICRLLQH 113

  Fly   133 GARLIGSEGNEFDVQEEQPASGGGEEDRSLASRLSRQRAVLNDKLGLTTAAKLGVNLTDMITDED 197
            ||.|:||.|.||:||:|:    .||.|..  .|::|||.:|..||||.....:|::..::..|||
Mouse   114 GASLLGSAGAEFEVQDEK----SGEVDPK--ERIARQRKLLQKKLGLNMGEAIGMSTEELFNDED 172

  Fly   198 V-------ALNRSGSTYNVNAEKLPVEHLLNIKTAANGSGQAPLSCREMNRAKRKARQNTSGCSV 255
            :       ||....||... ||.:..|.            :|.:|.|:.|:|||.|:......|.
Mouse   173 LDYTPTSAALVNKQSTLQA-AELIDSEF------------RAGMSNRQKNKAKRMAKLFAKQRSR 224

  Fly   256 TAVTPTCSRRNSNSNHSTGSNHSSNGTTGAAIEEPEKKKLK---------STDRQEIFYSLNAAV 311
            .||     ..|..||.||..             |||:|:.|         ::|.:.:..:    |
Mouse   225 DAV-----ETNEKSNDSTDG-------------EPEEKRRKVANVVINQTASDSKVLIDN----V 267

  Fly   312 PDATGTWVDAVSWPLENFCSRLFIDLFHAKWEVRHGAATALRELINQHAQGAGKAVLQTREQMDE 376
            |:::....:...||||:||..|..|||:..|||||||.|.|||::..|.:..||....|.|:|.:
Mouse   268 PESSSLIEETNEWPLESFCEELCNDLFNPSWEVRHGAGTGLREILKAHGKSGGKMGDSTLEEMIQ 332

  Fly   377 AHSRWLEDAALRLLCVLCLDRFGDFVSDQVVAPVRETCAQVLGTLVKEMEASKVQRIVNILLQLI 441
            .|..||||..:|||||..||||||||||:|||||||||||.||.::|.|..:.|.:.|::||:|:
Mouse   333 QHQEWLEDLVIRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVVLKHMNETGVHKTVDVLLKLL 397

  Fly   442 QHKNEWDVRHGGLLGLKYVFVVREELLPIYLPQSISNILIGLLDAVDDVGAVAAATLIPVSSWLP 506
            . :.:|:||||||||:||...||::::...||:.::.|:.||.|..|||.|||||:|:||...|
Mouse   398 T-QEQWEVRHGGLLGIKYALAVRQDVINTLLPKVLTRIIEGLQDLDDDVRAVAAASLVPVVESL- 460

  Fly   507 KLLNPAQVSSIVKMLWDLLLDQDELTSACNSFMGLLAAILCLPNAARWVEMEPMAILVPRLWPFL 571
            ..|...:|.||:..|||.||:.|:||::.||.|.||:::|..|...:....:.:.:||||:||||
Mouse   461 VYLQTQKVPSIINTLWDSLLELDDLTASTNSIMTLLSSMLTYPQVQQCSIQQSLTVLVPRVWPFL 525

  Fly   572 SHSTSSVRRSTLKTLMTLTSADRVKSEPKDENQVKEEADKEEMKLNFGVSDWKWELLQQALRHIY 636
            .|:.|||||:.|:||.||.|.       :|||.                |.|...:|...||||:
Mouse   526 HHTISSVRRAALETLFTLLST-------QDENS----------------SSWLIPILSDMLRHIF 567

  Fly   637 QRILVEPQADIQALARQVWSNLIQHADLGALLHAACPFVSSWICLSMQPPRLAFDAGVLIRAGGD 701
            |..::|...:|..|..:||..|:..|.:..|:.||||::|:|:||.|||..|..|..:|:..
Mouse   568 QFCVLESSQEILDLIHKVWMELLSKASVQYLVAAACPWMSAWLCLMMQPSHLPIDLNMLLEV--- 629

  Fly   702 VSTPGSTSRKRTPRIGDELGGNI---LAQSNASLKLYLGGSEATPLD--VRDANFMRARISSSRA 761
                       ..|..::.||.:   ..|:...|:.|:.|::....|  .||...||||:.:::.
Mouse   630 -----------KARAKEKTGGKVRQGQIQNKEVLQEYIAGADTIMEDPATRDFVVMRARMMAAKL 683

  Fly   762 LGALSHYLVQPAPGVVYTPQTESPTDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDEPVRPGP 826
            ||||..|:..|:..:|  .|...|.|...::||.:||:.||:|||...|:|..||...:..:...
Mouse   684 LGALCCYICDPSVNMV--NQEIKPADSLGQLLLFYLNSKSALQRISVALVICEWAALQKECKAVT 746

  Fly   827 PNLQEKLHQCVSEYVYYDEVAISLTRLLQEAQDFIATLKQNKIPINDFNNAKILTLDQIEAVATT 891
            ..:|.:|...:||::||||:|:..||:..|.:.||::|....|.:.:..|..:||:||...:.||
Mouse   747 LAVQPRLLDILSEHLYYDEIAVPFTRMQNECKQFISSLADAHIEVGNRVNNNVLTIDQANDLVTT 811

  Fly   892 L-SENLRSYPLKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALHCLPDKLNPV 955
            : :|...::.|.|:||..|:.:|..:|.:..:|..|.....:......|.|:.:|..||:||||:
Mouse   812 IFNEVTSTFDLNPQVLQQLDSKRHQVQMTVAETNQEWQVLQLRVHTFAACAVVSLQQLPEKLNPI 876

  Fly   956 VKPLMESIKREQCLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKLVMPL- 1019
            :|||||:||:|:...:|..:|:::..|:.|...|.|.||||::.|||:.|..||..||.:..|:
Mouse   877 IKPLMETIKKEENTLVQNYAAQYIAKLLQQCTTRTPCPNSKVIKNLCSSLCVDPYLTPCVTCPVP 941

  Fly  1020 -----ETLKQTPVSSEVINNCV--YYGILTLALQQTVTTTNTRSGAGGATTPTATTAPRGP---- 1073
                 |..|.:....:.:::.|  :.||:||...|...              .|.|:.|||
Mouse   942 TQSGQENSKGSNSEKDGMHHTVTKHRGIITLYRHQKAA--------------FAITSRRGPIPKA 992

  Fly  1074 GRPPTGEILSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVFQHL 1138
            .:....::.:.::.|..:||...|      |...:||.||..|:..:.:.||.::..|:......
Mouse   993 IKAQIADLPAGSSGTILVELDEGQ------KPYLVQRRGAEFALTTIVKHFGAEMAVKLPHLWDA 1051

  Fly  1139 MFGKVEQFVK-EAYDWRLGSLLPDLG--VCNELVSSMQLIETAAPHLHVALHPQMFALLPSLGFI 1200
            |.|.::..:. ..:|   |..|.:.|  ...|||:|:|:.|.||..:..||||.:...||.|...
Mouse  1052 MVGPLKSMIDLNNFD---GKSLLERGDVPAQELVNSLQVFEIAAASMDSALHPLLVQHLPHLYMC 1113

  Fly  1201 VCHPLKAVRHMAARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAIERVVSRLQIK 1265
            :.:|..||||||||||.|:::|...:||...:..:||.||.|:..::::|||||:..|:.:|.:.
Mouse  1114 LQYPSTAVRHMAARCIGVMSKIATMETMNIFLEKVLPWLGAIDDNVKQEGAIEALACVMEQLDVG 1178

  Fly  1266 VVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDG--KTEQLKSDPLQARKTRDREFL 1328
            :||||||||||:||.|||..:|||.::|.|||.|::||||:.  ......|:.|...|.::|.||
Mouse  1179 IVPYIVLLVVPVLGRMSDQTDSVRFMATQCFATLIRLMPLEAGIPDPPNMSEELIQLKAKERHFL 1243

  Fly  1329 DYLFNPKSIPNYKVPVPISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDH 1393
            :.|.:.|.:.|||:||||:.|||.|||.|:|||.|||||.||||||||||||||||:||||||||
Mouse  1244 EQLLDGKKLENYKIPVPINAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDH 1308

  Fly  1394 MHR-------QTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDI 1451
            ..|       :.|....|||||:||||||||||.||.||..: ..|.||||.|.|..|.:|:..:
Mouse  1309 CQRAQEYARSKLAECMPLPSLVVCPPTLTGHWVDEVGKFCSR-EYLNPLHYTGPPTERIRLQHQV 1372

  Fly  1452 GTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQ 1516
             .:.||:|||||.||.|||||..|.||||:|||||:|||||||.|||:|:|.||:|:||||||||
Mouse  1373 -KRHNLIVASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLTANYRIILSGTPIQ 1436

  Fly  1517 NNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLR 1581
            |||||||||||||||||||||:||..|:.:|||:||||:||::|||||||||:||||||||||||
Mouse  1437 NNVLELWSLFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMDALHRQVLPFLLR 1501

  Fly  1582 RVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTE--NLSAKTH 1644
            |:|||||:||||||.||..|.|||||::|||||:....|..:|:...|::.|..||  .|.|..|
Mouse  1502 RMKEDVLQDLPPKIIQDYYCTLSPLQVQLYEDFAKSRAKCDVDETVSSAALSEETEKPKLKATGH 1566

  Fly  1645 IFQALRYLQNVCNHPKLVLR-QSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGI--GV 1706
            :||||:||:.:||||.|||. |..|....|.:|.:.||||.||:|:.||.||||||||||:  |.
Mouse  1567 VFQALQYLRKLCNHPALVLTPQHPEFKSTTEKLTVQNSSLHDIQHAPKLSALKQLLLDCGLGNGS 1631

  Fly  1707 QTES-----VSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDP 1766
            .|||     |:|||.|||||||:||||||.|||:.|||||||||||||:|..||..||:.||:||
Mouse  1632 STESGTESVVAQHRILIFCQLKSMLDIVEHDLLKPHLPSVTYLRLDGSIPPGQRHSIVSRFNNDP 1696

  Fly  1767 SIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEE 1831
            |||||||||.||||||||||||||:|||||||||:||||||||||||||:||||||||||.:|||
Mouse  1697 SIDVLLLTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEE 1761

  Fly  1832 KIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAESGSSAVQGTASGGMSMNTII 1896
            |||||||||:..||||:|.||:|||:|||.|:.|||...||..||...|:..|.|    ||.:::
Mouse  1762 KIMGLQKFKMNIANTVISQENSSLQSMGTDQLLDLFTLDKDGKAEKADSSTSGKA----SMKSVL 1822

  Fly  1897 ENLPELWSEHQYEEEYDLGNFVQALK 1922
            |||.:||...||:.||:|..|:::|:
Mouse  1823 ENLSDLWDAEQYDSEYNLETFMRSLE 1848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787	17/24 (71%)
		HEAT repeat	42..70	CDD:293787	17/27 (63%)
		HEAT repeat	395..420	CDD:293787	22/24 (92%)
		HEAT repeat	433..465	CDD:293787	16/31 (52%)
		HEAT repeat	475..504	CDD:293787	15/28 (54%)
		HEAT repeat	516..540	CDD:293787	12/23 (52%)
		HEAT repeat	560..589	CDD:293787	17/28 (61%)
		DUF3535	654..1138	CDD:288874	151/501 (30%)
		HEAT repeat	1234..1261	CDD:293787	11/26 (42%)
		HEAT repeat	1269..1298	CDD:293787	19/28 (68%)
		SNF2_N	1353..1662	CDD:278600	211/317 (67%)
		DEXDc	1370..1514	CDD:238005	96/150 (64%)
		Helicase_C	1689..1813	CDD:278689	100/130 (77%)
Btaf1	NP_001074175.1	HEAT repeat	6..31	CDD:293787	17/24 (71%)
		HEAT repeat	43..71	CDD:293787	17/27 (63%)
		HEAT repeat	285..313	CDD:293787	17/27 (63%)
		HEAT repeat	351..376	CDD:293787	22/24 (92%)
		HEAT repeat	389..418	CDD:293787	15/29 (52%)
		HEAT_EZ	402..453	CDD:290247	27/50 (54%)
		HEAT repeat	429..459	CDD:293787	15/29 (52%)
		HEAT repeat	474..494	CDD:293787	10/19 (53%)
		HEAT repeat	505..540	CDD:293787	15/34 (44%)
		DUF3535	585..1050	CDD:288874	151/500 (30%)
		HEAT repeat	1107..1135	CDD:293787	15/27 (56%)
		HEAT repeat	1147..1170	CDD:293787	10/22 (45%)
		HEAT repeat	1183..1212	CDD:293787	19/28 (68%)
		SNF2_N	1268..1584	CDD:278600	211/317 (67%)
		DEXDc	1285..1434	CDD:238005	96/150 (64%)
		Helicase_C	1643..1743	CDD:278689	83/99 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833885
Domainoid	1	1.000	436	1.000	Domainoid score	I564
eggNOG	1	0.900	-	-		E1_KOG0392
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31978
Inparanoid	1	1.050	1557	1.000	Inparanoid score	I95
Isobase	1	0.950	-	0	Normalized mean entropy	S1216
OMA	1	1.010	-	-		QHG55547
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	1	1.000	-	-		FOG0004898
OrthoInspector	1	1.000	-	-		oto94328
orthoMCL	1	0.900	-	-		OOG6_101665
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R735
SonicParanoid	1	1.000	-	-		X3453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750