Protein Alignment Hel89B and chd1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_031749152.1
• Gene: chd1 / 100485675
• XenbaseID: XB-GENE-960477
• Length: 1797
• Species: Xenopus tropicalis
• Alignment Length: 741
• Identity: 225/741 - (30%)
• Similarity: 330/741 - (44%)
• Gaps: 185/741 - (24%)

  Fly  1225 CQTMQFVVHDLLPLLGKIEQLIER-------------------------------QGAIEA---- 1254
            ||      .:|:..|.|..|::||                               .||:.|
 Frog   376 CQ------QELIDDLHKQYQIVERIIAHSNQKSAAGYPDYFCKWQGLPYSECSWEDGALIAKKFQ 434

  Fly  1255 --IERVVSRLQIKVVPYIVLLVVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDGKTEQLKSDPL 1317
              |:..:||.|.|.:|:                       ..|              :.||..|
 Frog   435 ARIDEYISRNQSKTIPF-----------------------KEC--------------KVLKQRP- 461

  Fly  1318 QARKTRDREFLDYLFNPKSIPNYKVPVPISVELRCYQQAGINWL---WFLNKYNLHGILCDDMGL 1379
                    .|:.....|..|...|     .:|||.||..|:|||   |.  |.| ..||.|:|||
 Frog   462 --------RFVALKKQPSYIGGNK-----QLELRDYQLDGLNWLAHSWC--KGN-SCILADEMGL 510

  Fly  1380 GKTLQTICILAG-DHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVG 1443
            |||:|||..|.. .|.|:...     |.|::.|.:....|..|::.:   ..::..:.|.|....
 Frog   511 GKTIQTISFLNYLFHEHQLYG-----PFLLVVPLSTLTSWQREIQIW---APLMNAVVYLGDINS 567

  Fly  1444 REKLRS-------DIGTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKR 1501
            |..:|:       ....|.|:::.:|:.:.||..|..|:::.:..:||.|.:||..:...|.:..
 Frog   568 RNMIRTHEWMHPQTKRLKLNVLLTTYEILLKDKSFLGGVNWAFIGVDEAHRLKNDDSLLYKTLID 632

  Fly  1502 LKANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRD-AKSSAKEQEAGV 1565
            .|:||||:::|||:||::.|||||..|:||          ::||    |..| .:...|.:|.|
 Frog   633 FKSNHRLLITGTPLQNSLKELWSLLHFIMP----------EKFS----SWEDFEEEHGKGREYG- 682

  Fly  1566 LAMEALHRQVLPFLLRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSS 1630
              ..:||:::.||||||||:||.|.||.|:.|.|..|:|..|.:.|:....::.| .|.| |...
 Frog   683 --YASLHKELEPFLLRRVKKDVEKSLPAKVEQILRVEMSASQKQYYKWILTRNYK-ALSK-GSKG 743

  Fly  1631 SASMVTENLSAKTHIFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLDDIEHSAKLPAL 1695
            |.|          .....:..|:..|||..|: :..||......|.||.:.    |..|.||..|
 Frog   744 STS----------GFLNIMMELKKCCNHCYLI-KPPEENEFYNRQEALQHL----IRSSGKLILL 793

  Fly  1696 KQLLL---DCGIGVQTESVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQD 1757
            .:||:   :.|          :|.|||.|:..||||:.:.|..|..|   :.|||||:....|:.
 Frog   794 DKLLVRLRERG----------NRVLIFSQMVRMLDILAEYLKSRQFP---FQRLDGSIKGEVRKQ 845

  Fly  1758 IVNNFNSDPSID-VLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVY 1821
            .:::||::.|.| ..||:|..||||:||..||||:..:.||||..||||..|||||||||.||:|
 Frog   846 ALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIY 910

  Fly  1822 RLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAESGSSAVQGTA 1886
            ||:|:.|:||.|:...|.|::..:.|:       |.|.|:        ||.. ..:||:....|.
 Frog   911 RLVTKGSVEEDIIERAKKKMVLDHLVI-------QRMDTT--------GKTV-LHTGSTPSSSTP 959

  Fly  1887 SGGMSMNTIIE-NLPELWSEHQYEEE 1911
            .....:..|:: ...||:.|.:.|||
 Frog   960 FNKEELAAILKFGAEELFKEPEGEEE 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447
		HepA	<1342..1849	CDD:440319	185/522 (35%)
chd1	XP_031749152.1	CD1_tandem_CHD1-2_like	270..354	CDD:349313
		CD2_tandem_CHD1-2_like	387..443	CDD:349308	7/55 (13%)
		PLN03142	464..>1000	CDD:215601	203/601 (34%)
		CDH1_2_SANT_HL1	1123..1208	CDD:477096
		DUF4208	1491..1581	CDD:464035
		U2AF_lg	1669..>1778	CDD:273727
		HisXaaSer_A3	<1705..1744	CDD:439608