DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hel89B and hells

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	NP_001135693.1	Gene:	hells / 100216265	XenbaseID:	XB-GENE-5883772	Length:	840	Species:	Xenopus tropicalis

Alignment Length:	707	Identity:	206/707 - (29%)
Similarity:	311/707 - (43%)	Gaps:	157/707 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1283 DPDESVRLLSTHCFANLVQLMPLDGKTEQLKSDPL-QARKTRDREFLDYLFNPKSIPNYKV---P 1343
            |.:.|.:|.|.....|        |.:.....|.| |..:...::.||        |..||   |
Frog   161 DTNYSSKLTSEEIEKN--------GDSNSTIKDRLSQTVRNNTKQLLD--------PERKVNGQP 209

  Fly  1344 VPISVE-------LRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHRQTANL 1401
            ||....       :|.||..|:.||..|.:..::|||.|:||||||:|  ||.....|..:
Frog   210 VPFQQPKYFTGGVMRWYQIEGMEWLRMLWENGINGILADEMGLGKTVQ--CIATISMMVER---- 268

  Fly  1402 ANLPS-LVICPPTLT-GHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTK------CNLV 1458
             .:|. ..:|.|..| .:||.|.::|..:..||.   |:|....|.:|...|..:      ..:|
Frog   269 -GVPGPFFVCGPLSTLPNWVSEFKRFSPEVPVLL---YHGNAQERRRLARKINKREGSLQIYPVV 329

  Fly  1459 VASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELW 1523
            :.|::...:|........:.|.:|||||.|||...:..:.:|:.:::::|:|:|||:|||:.|||
Frog   330 ITSFEIAMRDRQILQHSPWKYMILDEGHRIKNMNCRLIQELKQFRSDNKLLLTGTPLQNNLAELW 394

  Fly  1524 SLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVL 1588
            ||.:||:|......:.|...|....:|.......|.|:|..:|.|  ||:.:.||||||:|.||.
Frog   395 SLLNFLLPDVFDDLRSFESWFDITGISQNAEDIVANEREQNILHM--LHQILTPFLLRRLKCDVT 457

  Fly  1589 KDLPPKITQDLLCELSPLQLRLYEDFSNK-----------HLK--------------------DC 1622
            .::|||....:...|:..|...|....||           |:|                    ..
Frog   458 LEVPPKREVVVYAPLTKKQETFYTAIVNKTIEKMLGQEKEHVKIISSPAVGRAKRRSRKAVNYSE 522

  Fly  1623 LDKLGDSSSASMVTENL----------SAKTHI----------FQALRYLQNVCNHPKLVLRQSE 1667
            |||...:....::.:.|          |||..:          ...:..|:..||||.|:....:
Frog   523 LDKDTPNDLEKLINQLLKQQEVEKERPSAKADLPLDSEVNLKMRNIMMLLRKCCNHPYLIEYPLD 587

  Fly  1668 ELT---KVTSQLALSNSS-----LDDIEHSAKLPALKQLLLDCGIGVQTESVSQHRALIFCQLKA 1724
            .||   |:..:|.  |||     ||.:     ||.:|:              ..|:.|||.|:..
Frog   588 PLTQDFKIDEELV--NSSGKFLLLDRL-----LPEMKK--------------RGHKVLIFSQMTM 631

  Fly  1725 MLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADT 1789
            ||||: .|..  :.....:.|||||:..|.|::.:..||::|.:.:.|::|..||||:|||.|||
Frog   632 MLDIL-MDYC--YYKKFNFCRLDGSMSYSDREENMRKFNTEPDVFIFLVSTRAGGLGINLTAADT 693

  Fly  1790 VIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENAS 1854
            ||..:.||||..||||.||.|||||.:.|.||||:|.|::::||:..            :|....
Frog   694 VIIYDSDWNPQADLQAQDRCHRIGQTRPVVVYRLVTANTIDQKIVER------------AAAKRK 746

  Fly  1855 LQTMGTSQIFDLFNGGKDKGAESGSSAVQGTASGGMSMNTIIENLPELWSEHQYEEE 1911
            |:.:       :.:..|.||.::|.:..:.....        :.|.||.....||.|
Frog   747 LEKL-------VIHKNKFKGGQTGINQSKSCLDP--------KELLELLQSRDYERE 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787	4/14 (29%)
		SNF2_N	1353..1662	CDD:278600	105/367 (29%)
		DEXDc	1370..1514	CDD:238005	45/151 (30%)
		Helicase_C	1689..1813	CDD:278689	49/123 (40%)
hells	NP_001135693.1	PLN03142	81..>816	CDD:215601	206/707 (29%)
hells	NP_001135693.1	DEXHc_HELLS_SMARCA6	220..453	CDD:350767	81/244 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920