DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hel89B and smarca1

DIOPT Version :9

Sequence 1:	NP_001287351.1	Gene:	Hel89B / 41943	FlyBaseID:	FBgn0022787	Length:	1923	Species:	Drosophila melanogaster
Sequence 2:	XP_002931866.2	Gene:	smarca1 / 100101797	XenbaseID:	XB-GENE-492011	Length:	1034	Species:	Xenopus tropicalis

Alignment Length:	625	Identity:	200/625 - (32%)
Similarity:	293/625 - (46%)	Gaps:	94/625 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1285 DESVR----LLSTHCFANLVQ-------LMPL-----------DGKTEQLKSDPLQARKTRDREF 1327
            |.|.|    |..|..||:.:|       ..||           |.|...|.:...:.|:|...|.
Frog    67 DRSKRFEFLLKQTELFAHFIQPAAQKSPTSPLKVKLGRPKIKKDEKQNLLSAGDYRHRRTEQEED 131

  Fly  1328 LDYLFNPKSIPNYKVPVPISVE------LRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTI 1386
            .:.|...:...|..|....|..      ||.||..|:||:..|.:..::|||.|:||||||||||
Frog   132 EELLSESRKTSNVCVRFEESPSYIKGGTLRDYQVRGLNWMISLYENGINGILADEMGLGKTLQTI 196

  Fly  1387 CILAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDI 1451
            .:|.....:|....    |.:|:.|.:...:|:.|.::::..   |..:...|....|.....|:
Frog   197 ALLGYLKHYRNIPG----PHMVLVPKSTLHNWMNEFKRWIPS---LCAVCLIGDKNARAAFIRDV 254

  Fly  1452 --GTKCNLVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTP 1514
              ..:.::.|.||:.|.|:...|...::.|.|:||.|.|||.|:|.|:.::..|..:||:|:|||
Frog   255 MMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTP 319

  Fly  1515 IQNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFL 1579
            :|||:.|||:|.:||:|....:.:.|...|        |..:...:|:    .:|.||..:.|||
Frog   320 LQNNLHELWALLNFLLPDVFNSAEDFDSWF--------DTNNCLGDQK----LVERLHAVLKPFL 372

  Fly  1580 LRRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTH 1644
            |||:|.:|.|.||||....:...|..:|...|.....|.: |.|:..|...           |..
Frog   373 LRRIKAEVEKSLPPKKEVKIYLGLGKMQREWYTKILMKDI-DILNSAGKMD-----------KMR 425

  Fly  1645 IFQALRYLQNVCNHPKLVLRQSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIGVQTE 1709
            :...|..|:..||||.| ...:|.....|:...|       :.:|.|:..|.:||       ...
Frog   426 LLNILMQLRKCCNHPYL-FDGAEPGPPYTTDTHL-------VYNSGKMVVLDKLL-------PKF 475

  Fly  1710 SVSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNS-DPSIDVLLL 1773
            .....|.|||.|:..:|||:|...:.|   ...|.||||..|..||:..:..||| :.|..:.:|
Frog   476 KEQGSRVLIFSQMTRVLDILEDYCMWR---GYEYCRLDGQTPHEQREAAIETFNSPNSSKFIFML 537

  Fly  1774 TTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQK 1838
            :|..||||:||..||.||..:.||||..|||||||||||||||.|.|:||||.|::||:|:...:
Frog   538 STRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQKKTVRVFRLITDNTVEERIVERAE 602

  Fly  1839 FKILTANTVVS------------AENASLQTM--GTSQIF 1864
            .|:...:.|:.            |::..||.:  |.:.:|
Frog   603 IKLRLDSIVIQQGRLIDQQSNKLAKDEMLQMIRHGATHVF 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_001287351.1	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:288874
		HEAT repeat	1234..1261	CDD:293787
		HEAT repeat	1269..1298	CDD:293787	6/16 (38%)
		SNF2_N	1353..1662	CDD:278600	99/310 (32%)
		DEXDc	1370..1514	CDD:238005	47/145 (32%)
		Helicase_C	1689..1813	CDD:278689	53/124 (43%)
smarca1	XP_002931866.2	PLN03142	64..1027	CDD:215601	200/625 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D61251at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010