Protein Alignment Hel89B and btaf1

DIOPT Version :10

• Sequence 1: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Sequence 2: XP_031762329.1
• Gene: btaf1 / 100038214
• XenbaseID: XB-GENE-488495
• Length: 1846
• Species: Xenopus tropicalis
• Alignment Length: 1970
• Identity: 905/1970 - (45%)
• Similarity: 1212/1970 - (61%)
• Gaps: 177/1970 - (8%)

  Fly     3 SRLDRLFILLETGSTAATRQAAAKQIGEVQKLYPHELHALLNRLVGYLHSTSWETRIAAAQTVEA 67
            ||||||||||:||:|..||:|||:|:|||.||:||||:.||::::.||.|.:|:|||||.|.|||
 Frog     4 SRLDRLFILLDTGTTPVTRKAAAQQLGEVVKLHPHELNNLLSKVLVYLRSPNWDTRIAAGQAVEA 68

  Fly    68 ILKQVPPWQPEFQVLPKKERCATNTATAAAAAEEDSCQSSGSNSTTASERLLSFDEFDLQQILHK 132
            |:|.:|.|.|..::  |||.                 ...|||..::....||||.||:.::|..
 Frog    69 IVKNIPEWNPATRL--KKEP-----------------GLEGSNEESSHLERLSFDRFDISRLLKH 114

  Fly   133 GARLIGSEGNEFDVQEEQPASGGGEEDRSLASRLSRQRAVLNDKLGLTTAAKLGVNLTDMITDED 197
            ||.|:||.|.||:||:::.    ||.|..  .|::|||.:|..||||...|.:|::..::..|||
 Frog   115 GASLLGSAGAEFEVQDDKT----GEVDPK--ERIARQRKLLQRKLGLDMGAAIGMSTEELFNDED 173

  Fly   198 VALNRSGSTYNVNAEKLPVEHLLNIKTAAN--GSGQAP-LSCREMNRAKRKARQNTSGCSVTAVT 259
            :             :.:|...||| |.||.  .|...| :|.|:.|:|||.|:         .:.
 Frog   174 L-------------DYMPTTALLN-KPAAEFIDSEFLPGMSNRQKNKAKRMAK---------LIA 215

  Fly   260 PTCSRRNSNSNHSTGSNHSSNGTTGAAIEEPEKKKLKSTD---RQEIFYS--LNAAVPDATGTWV 319
            ...||....:|..     ||:.|.|    |||:|:.|.|:   .|....|  |...|||.:..:.
 Frog   216 KQRSRDTIETNEK-----SSDSTDG----EPEEKRRKVTNVVINQPATESKVLIDNVPDNSSPYD 271

  Fly   320 DAVSWPLENFCSRLFIDLFHAKWEVRHGAATALRELINQHAQGAGKAVLQTREQMDEAHSRWLED 384
            :...||||:|...|..|||:..|||||||.|.|||::..|.:..||....|.|:|.:.|..||||
 Frog   272 EINEWPLESFSEELCNDLFNPSWEVRHGAGTGLREILKAHGRSGGKIADCTLEEMKQQHQDWLED 336

  Fly   385 AALRLLCVLCLDRFGDFVSDQVVAPVRETCAQVLGTLVKEMEASKVQRIVNILLQLIQHKNEWDV 449
            .|:|||||..||||||||||:|||||||||||.||.::|.|..:.|...|.|||:|: ::.:|:|
 Frog   337 LAIRLLCVFALDRFGDFVSDEVVAPVRETCAQTLGVVLKHMNENGVHNTVKILLKLL-NQEQWEV 400

  Fly   450 RHGGLLGLKYVFVVREELLPIYLPQSISNILIGLLDAVDDVGAVAAATLIPVSSWLPKLLNPAQV 514
            |||||||:||...:|::|:...||:::..|:.||.|..|||.|||||:|:||...|.| |...||
 Frog   401 RHGGLLGIKYALAIRQDLINSLLPKALPAIVEGLQDLDDDVRAVAAASLVPVVDSLVK-LQFKQV 464

  Fly   515 SSIVKMLWDLLLDQDELTSACNSFMGLLAAILCLPNAARWVEMEPMAILVPRLWPFLSHSTSSVR 579
            ..|:..|||.||:.|:||::.||.|.||:::|..|...:....:.:.|||||:||||.|:.||||
 Frog   465 PFIMSTLWDALLELDDLTASTNSIMTLLSSLLMYPQVQQCNVQQSLTILVPRVWPFLRHTISSVR 529

  Fly   580 RSTLKTLMTLTSADRVKSEPKDENQVKEEADKEEMKLNFGVSDWKWELLQQALRHIYQRILVEPQ 644
            ::.|:||.||.|.       :|:|                .|.|...:||..:|||:|..::|..
 Frog   530 KAALETLCTLLST-------QDQN----------------CSGWLTPILQDMMRHIFQICILESN 571

  Fly   645 ADIQALARQVWSNLIQHADLGALLHAACPFVSSWICLSMQPPRLAFDAGVLIRAGGDVSTPGSTS 709
            .:|..|..:||..|:..|.:..::.||||::.:|:||.|||..:..|..:|:.....
 Frog   572 QEIIDLIHKVWQELLNKASVQYVVAAACPWMGAWLCLMMQPSHIPIDLHMLLEVKAK-------- 628

  Fly   710 RKRTPRIGDELGGNILAQSNASLK----LYLGGSEATPLD--VRDANFMRARISSSRALGALSHY 768
                   ..|.||..|.|..:..|    .|:.||::...|  .||...:|||:::::.||:|...
 Frog   629 -------SKEKGGGKLRQCQSQTKEITQEYIAGSDSVNEDSSTRDYVVIRARVAAAKLLGSLCCC 686

  Fly   769 LVQPAPGVVYTPQTESPTDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDEPVRPGPPNLQEKL 833
            :.:|:  :....|...|.:...::||.|||:.||:|||...|:|:.||...:..|.....:|.:|
 Frog   687 ICEPS--INNLAQEIKPAESLAQLLLFHLNSKSALQRISVALVISEWAAMQKECRTVALAVQPRL 749

  Fly   834 HQCVSEYVYYDEVAISLTRLLQEAQDFIATLKQNKIPINDFNNAKILTLDQI-EAVATTLSENLR 897
            ...:||::||||:||..||:..|.:..|::|.:::|.|....|..:.|::|. :.|.|..||:..
 Frog   750 LAVLSEHLYYDEIAIPFTRMQNECKQLISSLAESQIDIRSKVNCSVFTINQANDLVTTVFSESTS 814

  Fly   898 SYPLKPKVLDMLEERRRSLQASYQQTTSEQSAYHVSAQAALAGAICALHCLPDKLNPVVKPLMES 962
            :.|:..|....|:.:|:.:|.:..:|:.|............|.|:..|..||:|||||:|||||:
 Frog   815 ALPVNSKQFQQLDAKRQQVQMTVMETSQEWQVLQQRVHTFGACAVVNLQQLPEKLNPVIKPLMEA 879

  Fly   963 IKREQCLQLQQLSAEFLVHLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKLVMPLETLKQTPV 1027
            :|||:...:|..:|..:..|:.|...|.|.||.||:.|||:.|..||..||.:..|...|.....
 Frog   880 VKREENAVVQNCAAMCIAKLLQQCTSRTPCPNPKIVKNLCSSLCIDPNITPTVTCPAPALNNVEN 944

  Fly  1028 S----SEVINNCVYY------GILTL-ALQQTVTTTNTRSGAGGATTPTATTAPRGPGRPPTGEI 1081
            |    ||  .:.:|:      ||:|| ..||......:|.|    .||.|:.:..|...|.:|..
 Frog   945 SKGPGSE--KDGMYHIFTKHRGIITLYRHQQAAFAITSRRG----PTPKASKSHVGDLPPGSGSC 1003

  Fly  1082 LSATNATAHIELKAQQAKEAEAKQCRIQRLGAACAIEKLCRIFGEQIIEKVAVFQHLMFGKVEQF 1146
            ::..:.            :...||..|||.||...:..:.|.|...:...:......|.|.:...
 Frog  1004 VNVADT------------DENQKQHHIQRRGAEFTVSTIARHFACDLASGLPHLWEAMLGPLRNN 1056

  Fly  1147 VK-EAYDWRLGSLLPDLG--VCNELVSSMQLIETAAPHLHVALHPQMFALLPSLGFIVCHPLKAV 1208
            :. :.:|   |.||.|.|  ...|||:|:|:.|..|..:...|||.:...|..|...:.||..||
 Frog  1057 ISPDNFD---GKLLLDKGDEAAQELVNSLQVFEVTAASMDPGLHPVLLQHLSHLFTCLQHPYTAV 1118

  Fly  1209 RHMAARCIAVLAEIDACQTMQFVVHDLLPLLGKIEQLIERQGAIEAIERVVSRLQIKVVPYIVLL 1273
            ||||:|||.:|:.|...:||...:..:||.||.|....:::||:||:..::.:|.:.:|||||||
 Frog  1119 RHMASRCIGILSRIATMETMNTFMEKVLPWLGAINDNTKQEGAMEALACIMEQLDVGIVPYIVLL 1183

  Fly  1274 VVPLLGAMSDPDESVRLLSTHCFANLVQLMPLDG--KTEQLKSDPLQARKTRDREFLDYLFNPKS 1336
            |||:||.|||..:|||.::|.|||.|::||||:.  ......|:.|...|.|:|.||:.|.:.|.
 Frog  1184 VVPVLGRMSDQTDSVRFMATQCFATLIRLMPLEAGIPDPPSMSEELIKLKARERNFLEQLLDGKK 1248

  Fly  1337 IPNYKVPVPISVELRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICILAGDHMHR----- 1396
            :.||.:||||..|||.|||.|:|||.|||||.||||||||||||||||:||||||||..|
 Frog  1249 LENYTIPVPIKAELRKYQQDGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHCQRSKEYS 1313

  Fly  1397 --QTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGTKCNLVV 1459
              ::|:...|||||:||||||||||.||.||..: ..|.||||.|.|..|.:|:..: .|.|:||
 Frog  1314 KNKSADCMPLPSLVVCPPTLTGHWVDEVGKFCSK-EYLNPLHYTGPPTERARLQHQV-KKHNMVV 1376

  Fly  1460 ASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPIQNNVLELWS 1524
            ||||.||.|||||..|.||||:|||||:|||||||.|||:|:|.||:|:||||||||||||||||
 Frog  1377 ASYDVVRNDIDFFRNIKFNYCILDEGHVIKNGKTKLSKAVKQLSANYRIILSGTPIQNNVLELWS 1441

  Fly  1525 LFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLLRRVKEDVLK 1589
            |||||||||||||:||..|:.:|||:||||:||::|||||||||||||||||||||||:|||||:
 Frog  1442 LFDFLMPGFLGTERQFAARYGKPILASRDARSSSREQEAGVLAMEALHRQVLPFLLRRMKEDVLQ 1506

  Fly  1590 DLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTEN----LSAKTHIFQALR 1650
            ||||||.||..|.|||||::|||||:....|..:|:  ..|:.|::.||    :.|..|:||||:
 Frog  1507 DLPPKIIQDYYCSLSPLQVQLYEDFAKSRAKTDIDE--TVSTTSLIEENEKPKVKATGHVFQALQ 1569

  Fly  1651 YLQNVCNHPKLVL-RQSEELTKVTSQLALSNSSLDDIEHSAKLPALKQLLLDCGIG------VQT 1708
            ||:.:||||.||| .|..|..|::.||.:.||||.||:|:.||.||||||||||:|      ..|
 Frog  1570 YLRKLCNHPALVLTTQHPEYKKISEQLGVQNSSLRDIQHAPKLSALKQLLLDCGLGNGGTAESGT 1634

  Fly  1709 ES-VSQHRALIFCQLKAMLDIVEQDLLRRHLPSVTYLRLDGSVPASQRQDIVNNFNSDPSIDVLL 1772
            |: |:|||.|||||||:||||||||||:.||||||||||||::||.||..||:.||:||||||||
 Frog  1635 EAVVAQHRILIFCQLKSMLDIVEQDLLKPHLPSVTYLRLDGTIPAGQRHSIVSRFNNDPSIDVLL 1699

  Fly  1773 LTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITRNSLEEKIMGLQ 1837
            |||.||||||||||||||:|||||||||:||||||||||||||:||||||||||.:|||||||||
 Frog  1700 LTTHVGGLGLNLTGADTVVFVEHDWNPMRDLQAMDRAHRIGQKRVVNVYRLITRGTLEEKIMGLQ 1764

  Fly  1838 KFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDKGAESGSSAVQGTASGGMSMNTIIENLPEL 1902
            |||:..||||:|.||||||:|||.|:.|||...||..:|...:|.:   ||..||.:|::.|.||
 Frog  1765 KFKMSIANTVISQENASLQSMGTDQLLDLFTLDKDGKSEKADAAKE---SGKSSMKSILDGLGEL 1826

  Fly  1903 WSEHQYEEEYDLGNFVQALK 1922
            |::.||:.|:.|.||:.:||
 Frog  1827 WNQEQYDSEFSLDNFMHSLK 1846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787	17/24 (71%)
		HEAT repeat	42..70	CDD:293787	16/27 (59%)
		HEAT repeat	395..420	CDD:293787	22/24 (92%)
		HEAT repeat	433..465	CDD:293787	16/31 (52%)
		HEAT repeat	475..504	CDD:293787	15/28 (54%)
		HEAT repeat	516..540	CDD:293787	11/23 (48%)
		HEAT repeat	560..589	CDD:293787	17/28 (61%)
		DUF3535	654..1138	CDD:463447	148/501 (30%)
		HepA	<1342..1849	CDD:440319	364/525 (69%)
btaf1	XP_031762329.1	HEAT repeat	285..320	CDD:293787	18/34 (53%)
		HEAT	335..449	CDD:441023	66/114 (58%)
		HEAT repeat	347..372	CDD:293787	22/24 (92%)
		HEAT repeat	385..414	CDD:293787	16/29 (55%)
		HEAT repeat	425..461	CDD:293787	18/36 (50%)
		HEAT repeat	470..490	CDD:293787	10/19 (53%)
		HEAT repeat	501..536	CDD:293787	15/34 (44%)
		DUF3535	581..1047	CDD:463447	148/500 (30%)
		HEAT repeat	1049..1087	CDD:293787	13/40 (33%)
		HEAT repeat	1102..1132	CDD:293787	14/29 (48%)
		HEAT repeat	1144..1170	CDD:293787	9/25 (36%)
		HEAT repeat	1180..1209	CDD:293787	19/28 (68%)
		HepA	<1254..1776	CDD:440319	364/525 (69%)