DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mor and smarcc2

DIOPT Version :9

Sequence 1:	NP_524373.1	Gene:	mor / 41942	FlyBaseID:	FBgn0002783	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	XP_021330286.1	Gene:	smarcc2 / 567476	ZFINID:	ZDB-GENE-100728-1	Length:	1036	Species:	Danio rerio

Alignment Length:	1190	Identity:	538/1190 - (45%)
Similarity:	726/1190 - (61%)	Gaps:	171/1190 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KKDGSPNIDFFQSPETLQGFESIRQWLQKNCKKYLAHSSEPITKESLAQLLIHFLQYVEAKLGKN 71
            ||||.||:.:|::.:|:..|:::|.||.||.|||:  .:||.|.:||:.|::..||:.|...|::
Zfish     5 KKDGGPNVKYFEASDTVSQFDNVRVWLGKNYKKYI--QAEPPTNKSLSSLVVQLLQFQEEVFGRH 67

  Fly    72 SADPPATRIPMRCFLDFKSGGGLCIIFSTMFRFRAEQRGKKFDFSIGKNPTRKDPNIQLLIEIEQ 136
            .::||.|::|::||||||:||.||.|.:..::|:::|..::|||   :||:|.|.|:::.:.||:
Zfish    68 VSNPPLTKLPVKCFLDFKAGGALCHILAAAYKFKSDQGWRRFDF---QNPSRMDRNVEMFMTIEK 129

  Fly   137 ALVEADLYRIPYIYIRPEIEKGFEGKLREILDNRRVEIVSDEEDATHIVYPV-VDPHPDEYARPI 200
            :||:.:....|.||:..|||....|||::|:...:..:..|:..::|:|.|: .....:|:.||:
Zfish   130 SLVQNNCLSRPVIYLSSEIEPKLLGKLKDIIKRHQGSVTEDKLSSSHVVVPIPASLEDEEWVRPV 194

  Fly   201 FKRGGHVMLHWYYFPESYDSWAVNNFDLPDHIPENPESPAERWRVSASWIVDLEQYNEWMAEEDY 265
            .||...::|||.|:|:|||:| ::..::...:.:.|.:...| :|.|.||:||:|:||||.||||
Zfish   195 MKRDKQMLLHWGYWPDSYDTW-ISASEVEAAVEDPPAAEKPR-KVHAKWILDLDQFNEWMNEEDY 257

  Fly   266 EVDEQGKKKTHKQRMSIDDIMSFGDEK--KKPAASSGGGKQKRRRSPSPASSASTSKPGKRKRSP 328
            ||.|.|.::......::.|.:|..||:  |||   ||..|:||..||||......||....|:.|
Zfish   258 EVGEGGPRRKRISAKTLTDEVSAPDERRDKKP---SGAKKRKRSPSPSPTPPPQESKKKNTKKGP 319

  Fly   329 AVVHKKSR---NDDDDEDLTRDLDDPPAEPNVQEVHKANAALQSTASPAPGGKSRGDNDMMPIKG 390
            ...:.||:   .:::.||||::||:|...|.|:|     |.|..|.       ::.|:|..|:||
Zfish   320 TTPYTKSKRGQREEEQEDLTKELDEPSPVPAVEE-----ATLPKTV-------TKKDSDSTPVKG 372

  Fly   391 GTMTDLDDEMTGGSAAQAMSTGDGENSQTGKTSDNSNTQEFSSSAKEDMEDNVTEQTHHIIVPSY 455
            |||||||::.............:|..|..|:....|:..          ||||||||||||:|||
Zfish   373 GTMTDLDEQEDESMETVGKEEEEGSPSVKGEPVKGSDLH----------EDNVTEQTHHIIIPSY 427

  Fly   456 SAWFDYNSIHVIEKRAMPEFFNSKNKSKTPEIYMAYRNFMIDTYRLNPTEYLTSTACRRNLAGDV 520
            :|||||||:|.||:||:|||||.||||||||||:||||||||||||||.||||||||||||||||
Zfish   428 AAWFDYNSVHAIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDV 492

  Fly   521 CAIMRVHAFLEQWGLINYQIDADVRPTPMGPPPTSHFHILSDTPSGLQSINPQKTQQPSAAKTLL 585
            |||||||||||||||||||:|::.||||||||||||||:|:||||.|..:.| |..|.|:::.:|
Zfish   493 CAIMRVHAFLEQWGLINYQVDSESRPTPMGPPPTSHFHVLADTPSSLVPLQP-KASQTSSSQQML 556

  Fly   586 DLDKKPLGKDGGLELGDKSGLTGIKTEALENGAAGGLSSGVSQFGLKLDQYAKKPAAMRNRTAAS 650
            ...:|...|...|:                            .|||:.|.|:||....:|:.|||
Zfish   557 SFPEKVKDKPADLQ----------------------------NFGLRTDVYSKKSGPAKNKNAAS 593

  Fly   651 MAREWTDQETLLLLEGLEMHKDDWNKVCEHVGSRTQDECILHFLRLPIEDPYLEDDGGFLGPLAC 715
            ..|||||||||||||||||:|||||||.|||||||||||||||||||||||||||....|||||.
Zfish   594 ATREWTDQETLLLLEGLEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLEDSSASLGPLAY 658

  Fly   716 QPIPFSKSGNPIMSTVAFLASVVDPRVAAAAAKAAMEEFAAIKDEVPATIMDNHLKNVEKAS-AG 779
            ||:|||::|||:||||||||||||||||:||||:|:|||:.:|:||||.:::.|::.||:|: |.
Zfish   659 QPVPFSQAGNPVMSTVAFLASVVDPRVASAAAKSALEEFSRMKEEVPAALVEAHVRRVEEAARAS 723

  Fly   780 GKFNPNFGLANSGIAGTGNDKDDEEGKEGGA--SASAGGSDEEMKDLSKKDDDAKSKDNTKSDKT 842
            |:.:|.:||..|||||||.:..|:...:||.  .:|.|...:|.:| ||:..|..|::..|..:.
Zfish   724 GRQDPLYGLEGSGIAGTGLEDSDKPSDDGGEENKSSEGQPSQEKRD-SKESKDGASEEEEKQGEN 787

  Fly   843 NTNTDSSSTSSSATGNTNNTDKKPKESSGSSPSGDKSAIKSDKSNKSSPTETAAAASGGEVDIKT 907
            ....:..:........|..||.:..:       |:|     :|..|..                :
Zfish   788 GKKEEERAREVETERETEKTDSEMAD-------GEK-----EKERKEG----------------S 824

  Fly   908 EDSSGDGETKDGTEAKEGTGTGTGPLAVPKEGTFSENNMQTAAAAALASAAVKAKHLAALEERKI 972
            |::..||||:...:||.....|             |.|:.||||:|||:||||||||||:|||||
Zfish   825 EEAQRDGETEGEKKAKVERDVG-------------EGNLATAAASALAAAAVKAKHLAAVEERKI 876

  Fly   973 KSLVALLVETQMKKLEIKLRHFEELEATMEREREGLEYQRQQLITERQQFHLEQLKAAEFRARQQ 1037
            ||||||||||||||||||||||||||..|:||||.||||||||:.:||.||:||||.||.|||||
Zfish   877 KSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQSFHMEQLKYAEMRARQQ 941

  Fly  1038 AHHRLQQELQGQAAAGSMILPQQQQLPQAQQPQQQQQTLPPHPHLAQQQQLPPHPHQLPPQSQPL 1102
            ...::|.:                  ..:.||..|..|.||.||                  ||:
Zfish   942 HFQQIQHQ------------------HHSNQPGSQSATAPPVPH------------------QPV 970

  Fly  1103 AGPTAQHQPLPPHVVSSPNGAPFAAPPISLTGGLPPGAPTAIVTNPSDQTGPVAAGAAQSQAPTP 1167
            |..:|     ||   .:|:.||..|  .:.....||  |.|..::|.:.|   .||||...:.||
Zfish   971 ATASA-----PP---PTPSPAPLTA--TNTHSEAPP--PPAAHSSPPNNT---QAGAAHDSSTTP 1020

  Fly  1168 M--DTTPPSSGPVSDANAPP 1185
            :  |:..|:: ||     ||
Zfish  1021 LAGDSLYPTA-PV-----PP 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mor	NP_524373.1	SWIRM-assoc_2	6..446	CDD:293105	161/444 (36%)
		RSC8	417..>742	CDD:227584	211/324 (65%)
		SWIRM	453..538	CDD:282311	76/84 (90%)
		SWIRM-assoc_3	738..801	CDD:293107	35/63 (56%)
		SWIRM-assoc_1	962..1031	CDD:293104	57/68 (84%)
smarcc2	XP_021330286.1	SWIRM-assoc_2	4..418	CDD:318656	161/444 (36%)
		SWIRM	380..>726	CDD:331975	234/384 (61%)
		Neuromodulin_N	<754..>935	CDD:331332	95/222 (43%)
		SWIRM-assoc_1	872..938	CDD:318655	54/65 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	301	1.000	Domainoid score	I1379
eggNOG	1	0.900	-	-		E1_COG5259
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2312
Inparanoid	1	1.050	946	1.000	Inparanoid score	I328
OMA	1	1.010	-	-		QHG55866
OrthoDB	1	1.010	-	-		D289848at33208
OrthoFinder	1	1.000	-	-		FOG0001152
OrthoInspector	1	1.000	-	-		otm25780
orthoMCL	1	0.900	-	-		OOG6_100909
Panther	1	1.100	-	-	O	PTHR12802
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3405
SonicParanoid	1	1.000	-	-		X781
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.960