DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mor and Smarcc1

DIOPT Version :9

Sequence 1:	NP_524373.1	Gene:	mor / 41942	FlyBaseID:	FBgn0002783	Length:	1209	Species:	Drosophila melanogaster
Sequence 2:	NP_033237.2	Gene:	Smarcc1 / 20588	MGIID:	1203524	Length:	1104	Species:	Mus musculus

Alignment Length:	1224	Identity:	537/1224 - (43%)
Similarity:	725/1224 - (59%)	Gaps:	191/1224 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KKDGSPNIDFFQSPETLQGFESIRQWLQKNCKKYLAHSSEPITKESLAQLLIHFLQYVEAKLGKN 71
            :|||.|...|::||:|:...:|:|.||.|:.|||: |:..| |.::||.|::..||:.|...||:
Mouse    32 RKDGGPASKFWESPDTVSQLDSVRVWLGKHYKKYV-HADAP-TNKTLAGLVVQLLQFQEDAFGKH 94

  Fly    72 SADPPATRIPMRCFLDFKSGGGLCIIFSTMFRFRAEQRGKKFDFSIGKNPTRKDPNIQLLIEIEQ 136
            ..:|..|::|.:||:|||:||.||.|....::::.||..::||.   :||:|.|.|:::.:.||:
Mouse    95 VTNPAFTKLPAKCFMDFKAGGTLCHILGAAYKYKNEQGWRRFDL---QNPSRMDRNVEMFMNIEK 156

  Fly   137 ALVEADLYRIPYIYIRPEIEKGFEGKLREILDNRRVEIVSDEEDATHIVYPVVDPHPD-EYARPI 200
            .||:.:....|.||:.|:|:.....||::|:...:.....::..|:|.:||......| |:.||:
Mouse   157 TLVQNNCLTRPNIYLIPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYPSSQEDEEWLRPV 221

  Fly   201 FKRGGHVMLHWYYFPESYDSWAVNNFDLPDHIPENPESPAERWRVSASWIVDLEQYNEWMAEEDY 265
            .:|...|::||.::|:|||:|..:| |:...|.:.| .|.:.|:|...||:|.:.:||||.||||
Mouse   222 MRRDKQVLVHWGFYPDSYDTWVHSN-DVDAEIEDAP-IPEKPWKVHVKWILDTDVFNEWMNEEDY 284

  Fly   266 EVDEQGKKKTHKQRMSI---DDIMSFGDEKKKPAASSGGGKQKRRRSPS---PASSASTSKPGKR 324
            ||||..|..:.:||:|.   :.:.|.....:|.:|:|    :||:.|||   |.::.|..|.||:
Mouse   285 EVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANS----RKRKPSPSPPPPTATESRKKSGKK 345

  Fly   325 KRSPAVVHKKSRNDDDD-EDLTRDLDDPPAEPNVQEVHKANAALQSTASPAPGGKSRGDNDMMPI 388
            .::.....::|:.::|: ||||:|::||...||::||     .|....:|      :.|::..|:
Mouse   346 GQASLYGKRRSQKEEDEQEDLTKDMEDPTPVPNIEEV-----VLPKNVNP------KKDSENTPV 399

  Fly   389 KGGTMTDLDDEMTGGSAAQAMSTGDGENSQTGKTSDNSNTQEFSSSAKEDMEDNVTEQTHHIIVP 453
            ||||:.|||::             |.|...||...|...::...|.:.:..||||||||:|||:|
Mouse   400 KGGTVADLDEQ-------------DEEAVTTGGKEDEDPSKGDPSRSVDPGEDNVTEQTNHIIIP 451

  Fly   454 SYSAWFDYNSIHVIEKRAMPEFFNSKNKSKTPEIYMAYRNFMIDTYRLNPTEYLTSTACRRNLAG 518
            ||::|||||.|||||:||:|||||.||||||||||:||||||||||||||.||||||||||||.|
Mouse   452 SYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLTG 516

  Fly   519 DVCAIMRVHAFLEQWGLINYQIDADVRPTPMGPPPTSHFHILSDTPSGLQSINPQKTQQPSAAKT 583
            ||||:||||||||||||:|||:|.:.||..||||||.||::|:||||||..::.:..|.| ||:.
Mouse   517 DVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVP-AAQQ 580

  Fly   584 LLDLDKKPLGKDGGLELGDKSGLTGIKTEALENGAAGGLSSGVSQFGLKLDQYAKKPAAMRNRTA 648
            :|:..:|  .|:..::|                          ..|||:.|.|:||..|  ....
Mouse   581 MLNFPEK--NKEKPIDL--------------------------QNFGLRTDIYSKKTLA--KSKG 615

  Fly   649 ASMAREWTDQETLLLLEGLEMHKDDWNKVCEHVGSRTQDECILHFLRLPIEDPYLEDDGGFLGPL 713
            ||..||||:||||||||.|||:|||||||.||||||||||||||||||||||||||:....||||
Mouse   616 ASAGREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLENSDASLGPL 680

  Fly   714 ACQPIPFSKSGNPIMSTVAFLASVVDPRVAAAAAKAAMEEFAAIKDEVPATIMDNHLKNVEKAS- 777
            |.||:|||:||||:||||||||||||||||:||||||:|||:.:::|||..:::.|:|.|::|:
Mouse   681 AYQPVPFSQSGNPVMSTVAFLASVVDPRVASAAAKAALEEFSRVREEVPLELVEAHVKKVQEAAR 745

  Fly   778 AGGKFNPNFGLANSGIAGTGNDKDDEEGKEGGASASAGGSDEEMKDLSKKDDDAKSKDNTKSDKT 842
            |.||.:|.:||.:|.|||||.|:.::          ..||:||                    |.
Mouse   746 ASGKVDPTYGLESSCIAGTGPDEPEK----------LEGSEEE--------------------KM 780

  Fly   843 NTNTDSSSTSSSATGNTNNTDKKPKESSGSSPSGDKSAIKSDKSNKSSPTETAAAASGGEVDIKT 907
            .|:.|......:.....|.:|:           |||  |:..::.|::..|..:..|   .|:|.
Mouse   781 ETDPDGQQPEKAENKVENESDE-----------GDK--IQDRENEKNTEKEQDSDVS---EDVKP 829

  Fly   908 EDSSGDGETKDGTEAKEGTGTGTGPLAVPKEGTFSENNMQTAAAAALASAAVKAKHLAALEERKI 972
            |:...: |.|:.|:..:...:..|...|..|  .||.|:.|||||||||||.|||||||:|||||
Mouse   830 EEKENE-ENKELTDTCKERESDAGKKKVEHE--ISEGNVATAAAAALASAATKAKHLAAVEERKI 891

  Fly   973 KSLVALLVETQMKKLEIKLRHFEELEATMEREREGLEYQRQQLITERQQFHLEQLKAAEFRARQQ 1037
            ||||||||||||||||||||||||||..|:||:|.||.|||||:||||.||:||||.||.|||||
Mouse   892 KSLVALLVETQMKKLEIKLRHFEELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRARQQ 956

  Fly  1038 AHHRLQQELQGQAAAGSMILPQQQQLPQAQQPQQ-QQQTLPP---------HPHLAQQQQLPPHP 1092
                               :.||||  ..|.||| .|.|..|         ||.:...||.||:|
Mouse   957 -------------------MEQQQQ--HGQTPQQAHQHTGGPGMAPLGATGHPGMMPHQQPPPYP 1000

  Fly  1093 ---HQLPPQSQP----LAGPTAQ--HQPLPPHVVSSPNGAPFAAPPISLTGG--LPPGAPTAIVT 1146
               ||:||...|    :.||.:.  .||:|..::      |..|..|..||.  .|||.|..
Mouse  1001 LMHHQMPPPHPPQPGQIPGPGSMMPGQPMPGRMI------PAVAANIHPTGSGPTPPGMPPM--- 1056

  Fly  1147 NPSDQTGPVAAGAA----------QSQAPTPMDTTPPSSGPVSDANAPPGSAMP 1190
             |.:..||.....|          |.|.|.|.|..||...|     .||.||.|
Mouse  1057 -PGNILGPRVPLTAPNGMYPPPPQQQQPPPPADGVPPPPAP-----GPPASATP 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mor	NP_524373.1	SWIRM-assoc_2	6..446	CDD:293105	153/446 (34%)
		RSC8	417..>742	CDD:227584	202/324 (62%)
		SWIRM	453..538	CDD:282311	73/84 (87%)
		SWIRM-assoc_3	738..801	CDD:293107	35/63 (56%)
		SWIRM-assoc_1	962..1031	CDD:293104	57/68 (84%)
Smarcc1	NP_033237.2	SWIRM-assoc_2	31..444	CDD:293105	153/446 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..445		53/177 (30%)
		RSC8	443..>709	CDD:227584	193/296 (65%)
		SWIRM	451..536	CDD:282311	73/84 (87%)
		SWIRM-assoc_3	705..769	CDD:293107	35/63 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..859		37/161 (23%)
		SWIRM-assoc_1	882..953	CDD:293104	58/70 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	955..1022		27/87 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1041..1104		23/71 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	298	1.000	Domainoid score	I1451
eggNOG	1	0.900	-	-		E1_COG5259
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	963	1.000	Inparanoid score	I325
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55866
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001152
OrthoInspector	1	1.000	-	-		otm44138
orthoMCL	1	0.900	-	-		OOG6_100909
Panther	1	1.100	-	-	LDO	PTHR12802
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3405
SonicParanoid	1	1.000	-	-		X781
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860