DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbf2 and RBR1

DIOPT Version :9

Sequence 1:	NP_524372.1	Gene:	Rbf2 / 41941	FlyBaseID:	FBgn0038390	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_566417.3	Gene:	RBR1 / 820408	AraportID:	AT3G12280	Length:	1013	Species:	Arabidopsis thaliana

Alignment Length:	972	Identity:	203/972 - (20%)
Similarity:	351/972 - (36%)	Gaps:	326/972 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CEQ-LELEARIQQSALSTYHRLDAV-------NGLSTSEADAQEWLCCAVYSELQRSKMRDIRES 77
            ||: |.|:......||..:.....:       .|..|.|...:.|....:|| ::|..:|...:.
plant    27 CEKVLSLDGSTCDEALKLFTETKRILSASMSNIGSGTREEVERFWFAFILYS-VKRLSVRKEADG 90

  Fly    78 INEANDSVAKNCCWNVSLTRLLRSFKMNVSQFLRRMEHW--------------NWLTQNENTFQL 128
            ::.:.|:       ..:|.::||:.|:|:..|.:.:..:              :|    ||  :|
plant    91 LSVSGDN-------EFNLCQILRALKLNIVDFFKELPQFVVKAGSVLGELYGADW----EN--RL 142

  Fly   129 EVEELRCRLGITSTLLRHYKHIFRSLFVHPGKGADPGAANHYQAL---YEFGWLLFLVIRNELPG 190
            :.:|::......|.|.::||..||..|:.....|:..:||....|   |.|||||||.:||.  .
plant   143 QAKEVQANFVHLSLLSKYYKRGFREFFLTYDANAEKNSANSSTYLLDSYRFGWLLFLALRNH--A 205

  Fly   191 FA----ITNLINGCQVLVCTMDLLFVNALEVP----------RSVVIRREFSGVP------KNWD 235
            |:    :....||      .:.:|.:..:.||          .|..:::...||.      |.:|
plant   206 FSRFKDLVTCSNG------VVSILAILIIHVPCRFRNFSIQDSSRFVKKGDKGVDLVASLCKIYD 264

  Fly   236 -TEDFNPILLNK-YSVLEALGELIPELPAKGVVQMKNAFFHKALIMLYMDHSLVGDDTHMREIIK 298
             :||...|:::| .:::|.:.:..|. ||......|            :|:......|:..::::
plant   265 ASEDELRIVIDKANNLVETILKKKPS-PASECQTDK------------LDNIDPDGLTYFEDLLE 316

  Fly   299 EGMLDINLENLNRKYTNQVADISEMDERVLLSVQ-----------GAIETKG-----DSPKSPQL 347
            |..:..:|..|.:.|.:   ...|:||||.::.:           ||:...|     |:..||.
plant   317 ETSISTSLITLEKDYYD---GKGELDERVFINEEDSLLGSGSLSAGAVNITGVKRKIDALSSPA- 377

  Fly   348 AFQTSSSPSHRKLSTHDLP-------------ASLPLS------------IIKAFPKKEDADKIV 387
              :|..||    ||.|..|             |:.|:|            |....||....
plant   378 --RTFISP----LSPHKSPAAKTNGISGATKLAATPVSTAMTTAKWLRTVISPLLPKPSPG---- 432

  Fly   388 NYLDQTLEEMNRTFT----------------------------MAVKDFLDAELSGKRFRQARGL 424
              |:..|:..:|..|                            :...|.:|...:.:|..:|..|
plant   433 --LEHFLKSCDRDITNDVTRRAHIILEAIFPNSSLGAQCGGGSLQAVDLMDDIWAEQRRLEACKL 495

  Fly   425 YYKYLQKILGPELVQKPQLKIGQLMKQRKLTAALLACCLELALHVHHKLVEGLRFPFVLHCFSLD 489
            ||:.|:.:...|........:..|:...:....:|||..||.|..|..:.  :.||.||....:.
plant   496 YYRVLEAMCKAEAQILHANNLNSLLTNERFHRCMLACSAELVLATHKTIT--MLFPAVLERTGIT 558

  Fly   490 AYDFQKILELVVRYDHGFLGRELIKHLDVVEEMCLDSLIFRKSSQLW-----------WELNQ-- 541
            |:|..|::|..:|::.. |.|||.:||:.:||..|:|:::.|.|.::           .|:||
plant   559 AFDLSKVIESFIRHEDS-LPRELRRHLNSLEERLLESMVWEKGSSMYNSLIVARPSLALEINQLG 622

  Fly   542 -----------------------------------------RLPR-----YKEVDAETEDKENFS 560
                                                     |.|:     |:.:..|   :.:|:
plant   623 LLAEPMPSLDAIAALINFSDGANHASSVQKHETCPGQNGGIRSPKRLCTDYRSILVE---RNSFT 684

  Fly   561 -------------------------------------------TGSSICLRKFYGLANRRLLLLC 582
                                                       ||.:|...|...||..|:..:.
plant   685 SPVKDRLLALGNVKSKMLPPPLQSAFASPTRPNPGGGGETCAETGINIFFTKINKLAAVRINGMV 749

  Fly   583 KSLCLVDSFPQ-IWHLAEHSFTLESSRLLRNRHLDQLLLCAIHLHVRLEKLHLTFSMIIQHYRRQ 646
            :.|.|.....: ::...:|.....:| ||.:||:||::||..:...::.::.|||..||.:||:|
plant   750 ERLQLSQQIRESVYCFFQHVLAQRTS-LLFSRHIDQIILCCFYGVAKISQMSLTFREIIYNYRKQ 813

  Fly   647 PHFRRSAYREVSLGNGQT----------ADIITFYNSVYVQSMGNYGRHLECAQTRKSLEESQSN 701
            |..:...:|.|.:...|.          .|||||||.:::.::             |.|
plant   814 PQCKPLVFRSVYVDALQCRRQGRIGPDHVDIITFYNEIFIPAV-------------KPL------ 859

  Fly   702 VGILTE--TTSNELSMRANISISSPPPPRVCQSGSCSSHP-----PSSPAASPLSLQSSPNV 756
               |.|  ...|:.::.||   :.|       .|.|...|     ||.|..||..:.:..||
plant   860 ---LVELGPVRNDRAVEAN---NKP-------EGQCPGSPKVSVFPSVPDMSPKKVSAVHNV 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf2	NP_524372.1	DUF3452	83..210	CDD:288762	36/147 (24%)
		RB_A	380..536	CDD:280101	42/183 (23%)
		CYCLIN	564..679	CDD:294043	36/125 (29%)
RBR1	NP_566417.3	DUF3452	92..226	CDD:371807	37/154 (24%)
		RB_A	406..607	CDD:366846	47/209 (22%)
		RB_B	729..857	CDD:366845	37/141 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	76	1.000	Domainoid score	I3152
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I1784
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	1	1.000	-	-		FOG0002362
OrthoInspector	1	1.000	-	-		otm2953
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13742
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.930