DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rbf2 and RBL2

DIOPT Version :9

Sequence 1:NP_524372.1 Gene:Rbf2 / 41941 FlyBaseID:FBgn0038390 Length:783 Species:Drosophila melanogaster
Sequence 2:NP_001310537.1 Gene:RBL2 / 5934 HGNCID:9894 Length:1139 Species:Homo sapiens


Alignment Length:1054 Identity:217/1054 - (20%)
Similarity:378/1054 - (35%) Gaps:354/1054 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EVEGEAE-----------TLVRRFSVSCEQLELEARIQQSALSTYHRLDAVNGLSTSEADAQEWL 58
            |.:||||           .:.:||...|.:|.::...:..|..:|.   :::...|.|.:...||
Human    26 EDDGEAEDAAPPAESPTPQIQQRFDELCSRLNMDEAARAEAWDSYR---SMSESYTLEGNDLHWL 87

  Fly    59 CCAVYSELQRSKMRDIRESINEANDSVAKNCCWNVSLTRLLRSFKMNVSQFLRRMEHWNWLTQNE 123
            .||:|...::| :..:.:...|.|         .|||||:|:..:.::.:|..:|:.|..:....
Human    88 ACALYVACRKS-VPTVSKGTVEGN---------YVSLTRILKCSEQSLIEFFNKMKKWEDMANLP 142

  Fly   124 NTFQLEVEELRCRLGITSTLLRHYKHIFRSLFVHPGKGADP----GAANHYQ-----ALYEFGWL 179
            ..|:...|.|.....:::.:.:.|:.||:.:|.:| :...|    |.....|     .::.|.|:
Human   143 PHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYP-QEEQPRQQRGRKQRRQPCTVSEIFHFCWV 206

  Fly   180 LFLVIRNELPGFAITNLINGCQVLVCTMDLLFVNALEVP-RSVVIRREFSGVPKNWDTEDFNP-- 241
            ||:..:...|..: .:|:|...:|:|.:||::.|||:.. |..::...|.|:.:::..:|..|  
Human   207 LFIYAKGNFPMIS-DDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDFHAKDSKPSS 270

  Fly   242 ----ILLNKYSVLEALGELIPELPAKGVVQMKNAFFHKALIMLYMDHSLVGDDTHMREIIKEGML 302
                |:....|:.:.|     .|.|||:   |..|:...:..||....|.|.:.::...::.|..
Human   271 DPPCIIEKLCSLHDGL-----VLEAKGI---KEHFWKPYIRKLYEKKLLKGKEENLTGFLEPGNF 327

  Fly   303 DINLENLNRKYTNQVADISEMDERVLL---------------------------SVQGAIETKGD 340
            ..:.:.:|:.|...|..:..:|||:.|                           .::..::...|
Human   328 GESFKAINKAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLNAGSGTETAERVQMKNILQQHFD 392

  Fly   341 SPKSPQLA-------FQTSSSPSHRKLS--THDL-------------PASLPLSIIKAFPKKEDA 383
            ..|:.:::       :...:||....:|  ||.|             |:.....|::.. .::..
Human   393 KSKALRISTPLTGVRYIKENSPCVTPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTC-SRDPT 456

  Fly   384 DKIVNYLDQTLEEMNRTFTMAVKDFLDA--ELSGKRFRQARGLYYKYLQKILGPELVQKPQLKIG 446
            ..|.|.|.:..|..::.| ...:||.:.  |::.|.||.|..||||.|:.::..|..:...:.:.
Human   457 QAIANRLKEMFEIYSQHF-QPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLS 520

  Fly   447 QLMKQRKLTAALLACCLELALHVHHKLVEGLRFPFVLHCFSLDAYDFQKILELVVRYDHGFLGRE 511
            .:::|.....:|||||||:....:..  .| .|||:...|.:..|.|.|::|:.:|.:.| |.||
Human   521 GILEQDAFHRSLLACCLEVVTFSYKP--PG-NFPFITEIFDVPLYHFYKVIEVFIRAEDG-LCRE 581

  Fly   512 LIKHLDVVEEMCLDSLIFRKSSQLWWEL---NQRLP---------------------------RY 546
            ::|||:.:||..||.|.::..|.||.::   ..|:|                           |.
Human   582 VVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERADEICIAGSPLTPRRV 646

  Fly   547 KEVDAET-------------EDK---------------ENFS----------------------- 560
            .||.|:|             .|:               ||.|                       
Human   647 TEVRADTGGLGRSITSPTTLYDRYSSPPASTTRRRLFVENDSPSDGGTPGRMPPQPLVNAVPVQN 711

  Fly   561 --------------------------------------------------------------TGS 563
                                                                          |||
Human   712 VSGETVSVTPVPGQTLVTMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVGGQAQAVTGS 776

  Fly   564 ------------------------------------------------------------SICLR 568
                                                                        |:..|
Human   777 IQPLSAQALAGSLSSQQVTGTTLQVPGQVAIQQISPGGQQQKQGQSVTSSSNRPRKTSSLSLFFR 841

  Fly   569 KFYGLANRRLLLLCKSLCLVDSF-PQIWHLAEHSFTLESSRLLRNRHLDQLLLCAIHLHVRLEKL 632
            |.|.||..||..||..|.:.|.. .:||...|.|. ::...|:.:|||||||:|||::..::.|.
Human   842 KVYHLAAVRLRDLCAKLDISDELRKKIWTCFEFSI-IQCPELMMDRHLDQLLMCAIYVMAKVTKE 905

  Fly   633 HLTFSMIIQHYRRQPHFRRSAYREVSLGNGQTADIITFYNSVYVQSMGNYGRHLECAQTRKSLEE 697
            ..:|..|::.||.||..|...||.| |..|:             :...|.|.           .:
Human   906 DKSFQNIMRCYRTQPQARSQVYRSV-LIKGK-------------RKRRNSGS-----------SD 945

  Fly   698 SQSNVGILTETTSNELSMRANISISSPPPPRVCQSGSCSSHPPSSPAASPLSLQSSPNVKRAASS 762
            |:|:....||...:..|.      .|.|..|     |.|:.|...|:::|      |...|...:
Human   946 SRSHQNSPTELNKDRTSR------DSSPVMR-----SSSTLPVPQPSSAP------PTPTRLTGA 993

  Fly   763 NDLMREIKRPNILR 776
            |..|.|.:|.::::
Human   994 NSDMEEEERGDLIQ 1007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rbf2NP_524372.1 DUF3452 83..210 CDD:288762 30/135 (22%)
RB_A 380..536 CDD:280101 49/157 (31%)
CYCLIN 564..679 CDD:294043 40/115 (35%)
RBL2NP_001310537.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..45 5/18 (28%)
DUF3452 104..236 CDD:288762 32/142 (23%)
Pocket, binds E1A 417..1024 132/640 (21%)
Domain A 417..616 57/204 (28%)
RB_A 417..609 CDD:280101 57/197 (29%)
Spacer 617..827 13/209 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..678 1/23 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 810..832 0/21 (0%)
Domain B 828..1024 61/223 (27%)
RB_B 835..1017 CDD:280100 61/216 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 933..999 20/106 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147371
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1010
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46367
OrthoDB 1 1.010 - - D113612at2759
OrthoFinder 1 1.000 - - FOG0002362
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13742
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.820

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