Protein Alignment Rbf2 and RBL1

DIOPT Version :9

• Sequence 1: NP_524372.1
• Gene: Rbf2 / 41941
• FlyBaseID: FBgn0038390
• Length: 783
• Species: Drosophila melanogaster
• Sequence 2: XP_024307724.1
• Gene: RBL1 / 5933
• HGNCID: 9893
• Length: 1105
• Species: Homo sapiens
• Alignment Length: 1104
• Identity: 228/1104 - (20%)
• Similarity: 384/1104 - (34%)
• Gaps: 395/1104 - (35%)

  Fly     8 GEAETLVRRFSVSCEQLELEARIQQSALSTYHRLDAVNGLSTSEADAQEWLCCAVYSELQRSKMR 72
            |||      ....|::|.|:   :.||........|:.|..:.|.:...||.|::|...::|.:.
Human    18 GEA------LQALCQELNLD---EGSAAEALDDFTAIRGNYSLEGEVTHWLACSLYVACRKSIIP 73

  Fly    73 DIRESINEANDSVAKNCCWNVSLTRLLRSFKMNVSQFLRRMEHWNWLTQNENTFQLEVEELRCRL 137
            .:.:.|.|.|       |  |||||:|||.|:::.||..:|:.|..::.....|:..:|.|....
Human    74 TVGKGIMEGN-------C--VSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNF 129

  Fly   138 GITSTLLRHYKHIFRSLFVHPGKGADPGAANHYQA--------LYEFGWLLFLVIRN-------- 186
            .:::.:.:.|:.||..:|.:|.:.......:..|.        |:.|.|.||:..:.
Human   130 EVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGKMTLSVVL 194

  Fly   187 ----------ELPGFAI------------------TNLINGCQVLVCTMDLLFVNALEVP-RSVV 222
                      ::.||..                  .:|:|...:|:|.:||:|.||:..| |..:
Human   195 HFYSGNLVLFDMRGFWFLCLFFFFFPYKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDL 259

  Fly   223 IRREFSGVPKNWDTEDFN-----PILLNKYSVLEALGE-LIPELPAKGVVQMKNAFFHKALIMLY 281
            :...|.|:|.::.|.||.     |.::   :||..|.: |:.|  |||:   |..:| |..|...
Human   260 LNPSFKGLPSDFHTADFTASEEPPCII---AVLCELHDGLLVE--AKGI---KEHYF-KPYISKL 315

  Fly   282 MDHSLVGDDTHMREIIK-EGMLDI-----NLENLNRKYTNQVADISEMDERVLL--SVQGAIETK 338
            .|          |:|:| |.:||:     |.:.:|::|...|..:.:.|||:.|  ..:..|.|.
Human   316 FD----------RKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTP 370

  Fly   339 GDSPKSPQLAFQTSSSPSHRKLSTH-----DLPASLPL--------------------------- 371
            ....:...|...|:.:.....|..|     ....|.||
Human   371 RKFTRDTPLGKLTAQANVEYNLQQHFEKKRSFAPSTPLTGRRYLREKEAVITPVASATQSVSRLQ 435

  Fly   372 SIIKAFPKKEDADKIVNYLD-----------QTLEEMNRTFTMAVKDFLD------AELSGKRFR 419
            ||:... |...:|:::|..:           :.|:.:..||........|      .:.:..|.:
Human   436 SIVAGL-KNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQPGSHIDFAVNRLK 499

  Fly   420 QARGLYYKYLQKILGPELVQKPQLKIGQLMKQRKLTAALLACCLELALHVHHKLVEGLRFPFVLH 484
            .|..||||.|:.::..|..:...:.:..|::|.....:|:|||||:.|..:.   ....||:::.
Human   500 LAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYS---SPRTFPWIIE 561

  Fly   485 CFSLDAYDFQKILELVVRYDHGFLGRELIKHLDVVEEMCLDSLIFRKSSQLWWELNQRL------ 543
            ..:|..:.|.|::|:|:|.:.| |.|:::|||:.:||..|:||.:...|.||..|....
Human   562 VLNLQPFYFYKVIEVVIRSEEG-LSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTC 625

  Fly   544 -------------------------------PRYKEVDAE------------------------- 552
                                           ||.|||..:
Human   626 EEVIFPNNFETGNGGNVQGHLPLMPMSPLMHPRVKEVRTDSGSLRRDMQPLSPISVHERYSSPTA 690

  Fly   553 ----------------------------------------------------------------- 552
                                                                             
Human   691 GSAKRRLFGEDPPKEMLMDKIITEGTKLKIAPSSSITAENVSILPGQTLLTMATAPVTGTTGHKV 755

  Fly   553 --------------------------------------------------TEDKENFSTG----- 562
                                                              |:.:|..|||
Human   756 TIPLHGVANDAGEITLIPLSMNTNQESKVKSPVSLTAHSLIGASPKQTNLTKAQEVHSTGINRPK 820

  Fly   563 --SSICL--RKFYGLANRRLLLLCKSLCLVDSF-PQIWHLAEHSFTL-ESSRLLRNRHLDQLLLC 621
              .|:.|  ||.|.||:.||..||..|.:.:.. .:||...|  ||| ....|:::|||||||||
Human   821 RTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFE--FTLVHCPDLMKDRHLDQLLLC 883

  Fly   622 AIHLHVRLEKLHLTFSMIIQHYRRQPHFRRSAYREVSL--------------------------- 659
            |.::..::.|...||..|::.||.||......||.|.|
Human   884 AFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLED 948

  Fly   660 -------GNG----QTADIITFYNSVYVQSMGNYGRHLECAQTRKSLEESQSNVGILTETTSNEL 713
                   .:|    :..|:|.|||::||..:.::....:.|.....::             :..|
Human   949 ATKTPDCSSGPVKEERGDLIKFYNTIYVGRVKSFALKYDLANQDHMMD-------------APPL 1000

  Fly   714 SMRANISISSPPPPRVCQSGSCSSHPPSSPAASPLSLQSSPNVKRAASSNDLMREIKRPNILRR 777
            |...:|......|.|:.|..|....|..:  .|.|:.:|:...|...|.:..:::|.  |::|:
Human  1001 SPFPHIKQQPGSPRRISQQHSIYISPHKN--GSGLTPRSALLYKFNGSPSKSLKDIN--NMIRQ 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbf2	NP_524372.1	DUF3452	83..210	CDD:288762	35/170 (21%)
		RB_A	380..536	CDD:280101	43/172 (25%)
		CYCLIN	564..679	CDD:294043	49/156 (31%)
RBL1	XP_024307724.1	DUF3452	77..246	CDD:314758	38/177 (21%)
		RB_A	422..615	CDD:307805	48/197 (24%)
		RB_B	824..979	CDD:307804	49/156 (31%)
		Rb_C	998..>1083	CDD:312478	16/67 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147367
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7132
OMA	1	1.010	-	-		QHG46367
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	1	1.000	-	-		FOG0002362
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.770