DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbf2 and Rb1

DIOPT Version :9

Sequence 1:	NP_524372.1	Gene:	Rbf2 / 41941	FlyBaseID:	FBgn0038390	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_058741.2	Gene:	Rb1 / 24708	RGDID:	3540	Length:	920	Species:	Rattus norvegicus

Alignment Length:	871	Identity:	174/871 - (19%)
Similarity:	336/871 - (38%)	Gaps:	231/871 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FSVSCEQLELEARIQQSALSTYHRLDAVNGLSTS--EADAQEWLCCAVYSELQRSKMRDIRESIN 79
            |...|::|::...:::.|..|:.::.:|:|:...  :...:.|..|...:.:...:|
  Rat    50 FIALCQKLKVPDHVRERAWLTWEKVSSVDGILEGYIQKKKELWGICIFIAAVDLDEM-------- 106

  Fly    80 EANDSVAKNCCWNVSLTRLLRSFKMNVSQFLRRMEHWNWLTQNENTFQLEVEELRCRLGITSTLL 144
                        ..:.|.|.:|.:.:|.:|...::..:..|:.:|.....:::......:.|.|.
  Rat   107 ------------PFTFTELQKSIETSVYKFFDLLKEIDTSTKVDNAVSRLLKKYNVLCALYSKLE 159

  Fly   145 RHYKHIFRSLFVHPGKGADPGAANHYQALYEFGWLLFLVIRNELPGFAITNLINGCQVLVCTMDL 209
            |....|:   ...|..|.  ....:...:.:..|:.||:.:.|:.... .:|:...|:::|.:|.
  Rat   160 RTCGLIY---LTQPSSGL--STEINSMLVLKVSWITFLLAKGEVVQME-DDLVISFQLMLCVLDY 218

  Fly   210 LFVNALEVPRSVVIRREF--SGVPKNWDTEDFNPILLNKYSVLEALGELIPELPAKGVVQMKNAF 272
            .    :::....::|..:  :..|.|..                      |..|.:|  |.::|.
  Rat   219 F----IKLSPPALLREPYKTAATPINGS----------------------PRTPRRG--QNRSAR 255

  Fly   273 FHKAL-------IMLYMDHSLVGDD---THMREII----KEGMLDIN----LENLNRKYTNQVAD 319
            ..|.|       .:|..:|....|:   .:.:..|    ..|::..|    ||:|:::|......
  Rat   256 IAKQLESDTRTIEVLCKEHECNVDEVKNVYFKNFIPFISSLGIVSSNGLPELESLSKRYEEVYLK 320

  Fly   320 ISEMDERVLLSVQGAIETKGDSPKSPQLAFQTSSSPSHRKLSTHDLPASL--------------- 369
            ..::|.|:.|.....::|  |:..|    |:|..:|  || |..|..|::
  Rat   321 SKDLDARLFLDHDKTLQT--DTIDS----FETERTP--RK-SNPDEEANMVTPHTPVRTVMNTIQ 376

  Fly   370 PLSIIKAFPKKEDADKIVNYLDQTLEEMNRTFTMAVKD--------FLDA------ELSGKRFRQ 420
            .|.:|......:.::.:::|...............|||        |..|      ::..:|::.
  Rat   377 QLMVILNSASDQPSENLISYFSNCTVNPKENILKRVKDVGHIFKEKFASAVGQGCIDIGAQRYKL 441

  Fly   421 ARGLYYKYLQKILGPELVQKPQLKIGQLMKQRKLTAALLACCLELALHVHHK-----LVEG--LR 478
            ...|||:.::.:|..|..:.......:|:.......:||||.||:.:..:.:     |..|  |.
  Rat   442 GVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSMLQNLDSGTDLS 506

  Fly   479 FPFVLHCFSLDAYDFQKILELVVRYDHGFLGRELIKHLDVVEEMCLDSLIFRKSSQLWWELNQ-- 541
            ||::|:..:|.|:||.|::|..::.:.. |.||:||||:..|...::||.:...|.|:..:.|
  Rat   507 FPWILNVLNLKAFDFYKVIESFIKVEAN-LTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSK 570

  Fly   542 --------------------------------RLPRYK--------EVDAETEDKENF------- 559
                                            |.|:.:        ..:.||:....|
  Rat   571 DGEGPDHLESACSLSLPLQSNHTAADMYLSPIRSPKKRTSTTRVNSAANTETQAASAFHTQKPLK 635

  Fly   560 STGSSICLRKFYGLANRRLLLLCKSLCLVDSFPQ----IWHLAEHSFTLESS-RLLRNRHLDQLL 619
            ||..|:..:|.|.||..||..||..  |:...|:    ||.|.:|  |||:. .|:::|||||::
  Rat   636 STSLSLFYKKVYRLAYLRLNTLCAR--LLSDHPELEHIIWTLFQH--TLENEYELMKDRHLDQIM 696

  Fly   620 LCAIHLHVRLEKLHLTFSMIIQHYRRQPHFRRSAYREVSLGNGQTADIITFYNSVYVQSMGNYGR 684
            :|:::...:::.:.|.|.:|:..|:..||..:..::.|.:...:...||.|||||::|.:
  Rat   697 MCSMYGICKVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRL----- 756

  Fly   685 HLECAQTRKSLEESQSNVGILTETTSNELSMRANISISSPPPPRVCQSGSCSSHPPSSP---AAS 746
                          ::|:                :..:|..||.:    |...|.|.||   ::|
  Rat   757 --------------KTNI----------------LQYASTRPPTL----SPIPHIPRSPYKFSSS 787

  Fly   747 PLSLQSSPNVKRAASSNDLMREIKRP 772
            ||         |....|..:..:|.|
  Rat   788 PL---------RIPGGNIYISPLKSP 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf2	NP_524372.1	DUF3452	83..210	CDD:288762	21/126 (17%)
		RB_A	380..536	CDD:280101	42/176 (24%)
		CYCLIN	564..679	CDD:294043	40/119 (34%)
Rb1	NP_058741.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		DUF3452	108..218	CDD:403219	20/115 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..362		9/28 (32%)
		Pocket, binds T and E1A. /evidence=ECO:0000250	366..763		94/436 (22%)
		Domain A. /evidence=ECO:0000250	366..572		46/206 (22%)
		RB_A	366..566	CDD:396434	45/200 (23%)
		Spacer. /evidence=ECO:0000250	573..631		5/57 (9%)
		Domain B. /evidence=ECO:0000250	632..763		43/169 (25%)
		CYCLIN_RB	637..763	CDD:410302	42/164 (26%)
		Interaction with LIMD1. /evidence=ECO:0000250	755..920		16/98 (16%)
		Rb_C	760..917	CDD:401034	15/74 (20%)
		Domain C, mediates interaction with E4F1. /evidence=ECO:0000250	763..920		15/55 (27%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P13405	852..868
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..920
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341021
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13742
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850