DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rbf2 and Rbl1

DIOPT Version :9

Sequence 1:NP_524372.1 Gene:Rbf2 / 41941 FlyBaseID:FBgn0038390 Length:783 Species:Drosophila melanogaster
Sequence 2:NP_035379.2 Gene:Rbl1 / 19650 MGIID:103300 Length:1063 Species:Mus musculus


Alignment Length:1062 Identity:222/1062 - (20%)
Similarity:381/1062 - (35%) Gaps:352/1062 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 EGEAETLVRRFSVS--CEQLELEARIQQSALSTYHRLDAVNGLSTSEADAQEWLCCAVYSELQRS 69
            ||.|.....|.::.  |::|.|:   :.||........|:.|..:.|.:...||.|::|...::|
Mouse     9 EGAAAVAAAREALQALCQELNLD---EGSAAEALDDFTAIRGNYSLEGEVIHWLACSLYVACRKS 70

  Fly    70 KMRDIRESINEANDSVAKNCCWNVSLTRLLRSFKMNVSQFLRRMEHWNWLTQNENTFQLEVEELR 134
            .:..:.:.:.|.|       |  |||||:|||.|:::.||..:|:.|..::.....|:..:|.|.
Mouse    71 IIPTVGKGVMEGN-------C--VSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLE 126

  Fly   135 CRLGITSTLLRHYKHIFRSLFVHPGKGADPGAANHYQA--------LYEFGWLLFLVIRNELPGF 191
            ....:::.:.:.::.||..:|.:|.:.......:..|.        |:.|.|.||:..:......
Mouse   127 RNFEVSTVIFKKFEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMI 191

  Fly   192 AITNLINGCQVLVCTMDLLFVNALEVP-RSVVIRREFSGVPKNWDTEDFN-----PILLNKYSVL 250
            . .:|:|...:|:|.:||:|.||:..| |..::...|.|:|.::...||.     |.::   :||
Mouse   192 G-DDLVNSYHLLLCCLDLIFANAIMCPNRRDLLNPSFKGLPSDFHAPDFKAAEEPPCII---AVL 252

  Fly   251 EALGE-LIPELPAKGVVQMKNAFFHKALIMLYMDHSLVGDDTHMREIIK-EGMLDI-----NLEN 308
            ..|.: |:.|  |||:   |..:| |..|....|          ::|:| |.:||:     |.:.
Mouse   253 CDLHDGLLVE--AKGI---KEHYF-KPYISKLFD----------KKILKGECLLDLSSFTDNSKA 301

  Fly   309 LNRKYTNQVADISEMDERVLLSV-----------------------QGAIETKGDSPKSPQLAFQ 350
            :|::|...|..:.:.|||:.|..                       |.::|.........:.:|.
Mouse   302 VNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTADTPFGKLTSQASVECNLQQHFEKKRSFA 366

  Fly   351 TSSSPSHRKLSTHDLPASLP----------LSIIKAFPKKEDADKIVNYLDQTLEE--------- 396
            .|:..:.|:........:.|          |..|.|..|...:::::|..:..:..         
Mouse   367 PSTPLTGRRYLQEKEAVTTPVASATQSVSRLQSIVAGLKSAPSEQLLNIFESCMRNPMGNIIKIV 431

  Fly   397 --MNRTFTMAVKDFLD------AELSGKRFRQARGLYYKYLQKILGPELVQKPQLKIGQLMKQRK 453
              :..||........|      .:.:..|.:.|..||||.|:.|:..|..:...:.:..|::|..
Mouse   432 KGIGETFCQHYTQSTDKQPGSHIDFAVNRLKLAEILYYKILETIMVQETRRLHGMDMSVLLEQDI 496

  Fly   454 LTAALLACCLELALHVHHKLVEGLRFPFVLHCFSLDAYDFQKILELVVRYDHGFLGRELIKHLDV 518
            ...:|:|||||:.|..:.   ....||:::....|..:.|.|::|:|:|.:.| |.|:::|||:.
Mouse   497 FHKSLMACCLEIVLFAYS---SPRTFPWIIEVLDLQPFYFYKVIEVVIRSEEG-LSRDMVKHLNS 557

  Fly   519 VEEMCLDSLIFRKSSQLWWELNQRL-------------------------------------PRY 546
            :||..|:||.:..:|.||..|:...                                     ||.
Mouse   558 IEEQILESLAWTNNSALWEALHASANRVPSCEEVIFPNNFEIGNGGNVQGHLPMMPMSPIIHPRV 622

  Fly   547 KEVDAET----EDKENFS----------------------------------------------- 560
            |||..::    :|.:..|                                               
Mouse   623 KEVRTDSGSLRQDMQPLSPISVHERYSSPAAGSAKRRLFGDDPPKDTLMDKIMAEGTKLKIAPSS 687

  Fly   561 ----------------------------------------------------------------- 560
                                                                             
Mouse   688 VTAESLSISPGQALLTMATTTVTGTTGRKVTVPLHGIANDAGEITLVPISMNPTQESTAESPVSL 752

  Fly   561 -------------------------------TGS-SICLRKFYGLANRRLLLLCKSLCLVDSF-P 592
                                           ||| ::..||.|.||:.||..||..|.:.:.. .
Mouse   753 TAQSLIGTSPKQTHLTKAQDAHLTGVSKPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRR 817

  Fly   593 QIWHLAEHSFTL-ESSRLLRNRHLDQLLLCAIHLHVRLEKLHLTFSMIIQHYRRQPHFRRSAYRE 656
            :||...|  ||| ....|:::||||||||||.::..::.|...||..|::.||.||......||.
Mouse   818 KIWTCFE--FTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRS 880

  Fly   657 VSLG---------NG-------------------------QTADIITFYNSVYVQSMGNYGRHLE 687
            |.|.         ||                         :..|:|.|||:|||..:.::     
Mouse   881 VLLKSIPGGVVVYNGDCEMTDGDIEDATKTPNCSSEPVKEERGDLIKFYNTVYVGRVKSF----- 940

  Fly   688 CAQTRKSLEESQSNVGILTETTSNELSMRANISISSPPPPRVCQSGSCSSHPPSSPAA-SPLS-- 749
                  :|:...||...:.:  :..||...:|......|.|:.|..|....|..:.|. :|.|  
Mouse   941 ------ALKYDLSNQDHIMD--APPLSPFPHIKQQPGSPRRISQQHSLYVSPHKNGAGLTPRSAL 997

  Fly   750 ---LQSSPNVKRAASSNDLMRE 768
               ...||: |.....|:::|:
Mouse   998 LYKFNGSPS-KSLKDINNMIRQ 1018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rbf2NP_524372.1 DUF3452 83..210 CDD:288762 32/134 (24%)
RB_A 380..536 CDD:280101 42/172 (24%)
CYCLIN 564..679 CDD:294043 49/150 (33%)
Rbl1NP_035379.2 DUF3452 77..209 CDD:288762 34/141 (24%)
Pocket, binds T and E1A. /evidence=ECO:0000250|UniProtKB:P28749 383..944 110/577 (19%)
Domain A. /evidence=ECO:0000305 383..584 50/204 (25%)
RB_A 385..578 CDD:280101 49/196 (25%)
Spacer. /evidence=ECO:0000305 585..779 7/193 (4%)
Domain B. /evidence=ECO:0000305 780..944 53/176 (30%)
RB_B 786..937 CDD:280100 50/152 (33%)
Rb_C 956..>1041 CDD:286075 16/64 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837303
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1010
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7132
OMA 1 1.010 - - QHG46367
OrthoDB 1 1.010 - - D113612at2759
OrthoFinder 1 1.000 - - FOG0002362
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13742
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
109.770

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