DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbf2 and Rb1

DIOPT Version :9

Sequence 1:	NP_524372.1	Gene:	Rbf2 / 41941	FlyBaseID:	FBgn0038390	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_033055.2	Gene:	Rb1 / 19645	MGIID:	97874	Length:	921	Species:	Mus musculus

Alignment Length:	916	Identity:	176/916 - (19%)
Similarity:	345/916 - (37%)	Gaps:	295/916 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METCEVEGEAETLVRRFSVSCEQLELEARIQQSALSTYHRLDAVNGLSTS--EADAQEWLCCA-- 61
            :|..|:| |.|     |...|::|::...:::.|..|:.::.:|:|:...  :...:.|..|.
Mouse    41 LEFEEIE-EPE-----FIALCQKLKVPDHVRERAWLTWEKVSSVDGILEGYIQKKKELWGICIFI 99

  Fly    62 ----------VYSELQRS------KMRDIRESINEAN--DSVAKNCCWNVSLTRLLRSFKMNVSQ 108
                      .::|||:|      |..|:.:.|:.:.  |:         :::|||:.:.:..:.
Mouse   100 AAVDLDEMPFTFTELQKSIETSVYKFFDLLKEIDTSTKVDN---------AMSRLLKKYNVLCAL 155

  Fly   109 F--LRRMEHWNWLTQNENTFQLEVEELRCRLGITSTLLRHYKHIFRSLFVHPGKGADPGAANHYQ 171
            :  |.|.....:|||..:....|:..:
Mouse   156 YSKLERTCELIYLTQPSSALSTEINSM-------------------------------------- 182

  Fly   172 ALYEFGWLLFLVIRNELPGFAITNLINGCQVLVCTMDLLFVNALEVPRSVVIRREF--SGVPKNW 234
            .:.:..|:.||:.:.|:.... .:|:...|:::|.:|..    ::.....::|..:  :.:|.|.
Mouse   183 LVLKISWITFLLAKGEVLQME-DDLVISFQLMLCVVDYF----IKFSPPALLREPYKTAAIPING 242

  Fly   235 DTEDFNPILLNKYSVLEALGELIPELPAKGVVQMKNAFFHKALIMLYMDHSLVGDDTHMREII-K 298
            .                      |..|.:|  |.::|...|.|          .:||.:.|:: |
Mouse   243 S----------------------PRTPRRG--QNRSARIAKQL----------ENDTRIIEVLCK 273

  Fly   299 E-----------------------GMLDIN----LENLNRKYTNQVADISEMDERVLLSVQGAIE 336
            |                       |::..|    :|:|:::|........::|.|:.|.....::
Mouse   274 EHECNIDEVKNVYFKNFIPFINSLGIVSSNGLPEVESLSKRYEEVYLKNKDLDARLFLDHDKTLQ 338

  Fly   337 TKGDSPKSPQLAFQTSSSP------SHRKLSTHDLPASLPLSIIKAF------PKKEDADKIVNY 389
            |      .|..:|:|..:|      ....:.|...|....::.|:..      ...:.::.:::|
Mouse   339 T------DPIDSFETERTPRKNNPDEEANVVTPHTPVRTVMNTIQQLMVILNSASDQPSENLISY 397

  Fly   390 LDQTLEEMNRTFTMAVKD--------FLDA------ELSGKRFRQARGLYYKYLQKILGPELVQK 440
            .:.............|||        |.:|      ::..:|::....|||:.::.:|..|..:.
Mouse   398 FNNCTVNPKENILKRVKDVGHIFKEKFANAVGQGCVDIGVQRYKLGVRLYYRVMESMLKSEEERL 462

  Fly   441 PQLKIGQLMKQRKLTAALLACCLELALHVHHK-----LVEG--LRFPFVLHCFSLDAYDFQKILE 498
            ......:|:.......:||||.||:.:..:.:     |..|  |.||::|:..:|.|:||.|::|
Mouse   463 SIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTLQHLDSGTDLSFPWILNVLNLKAFDFYKVIE 527

  Fly   499 LVVRYDHGFLGRELIKHLDVVEEMCLDSLIFRKSSQLWWELNQ---------------------- 541
            ..::.:.. |.||:||||:..|...::||.:...|.|:..:.|
Mouse   528 SFIKVEAN-LTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGPDNLEPACPLSLPLQG 591

  Fly   542 ------------RLPRYK--------EVDAETEDKENF-------STGSSICLRKFYGLANRRLL 579
                        |.|:.:        ..:.||:....|       ||..::..:|.|.||..||.
Mouse   592 NHTAADMYLSPLRSPKKRTSTTRVNSAANTETQAASAFHTQKPLKSTSLALFYKKVYRLAYLRLN 656

  Fly   580 LLCKSLCLVDSFPQ----IWHLAEHSFTLESS-RLLRNRHLDQLLLCAIHLHVRLEKLHLTFSMI 639
            .||..  |:...|:    ||.|.:|  ||::. .|:|:|||||:::|:::...:::.:.|.|.:|
Mouse   657 TLCAR--LLSDHPELEHIIWTLFQH--TLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKII 717

  Fly   640 IQHYRRQPHFRRSAYREVSLGNGQTADIITFYNSVYVQSMGNYGRHLECAQTRKSLEESQSNVGI 704
            :..|:..||..:..::.|.:...:...||.|||||::|.:                   ::|:
Mouse   718 VTAYKDLPHAAQETFKRVLIREEEFDSIIVFYNSVFMQRL-------------------KTNI-- 761

  Fly   705 LTETTSNELSMRANISISSPPPPRVCQSGSCSSHPPSSP---AASPLSLQSSPNVKRAASSNDLM 766
                          :..:|..||.:    |...|.|.||   ::|||         |....|..:
Mouse   762 --------------LQYASTRPPTL----SPIPHIPRSPYKFSSSPL---------RIPGGNIYI 799

  Fly   767 REIKRP 772
            ..:|.|
Mouse   800 SPLKSP 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf2	NP_524372.1	DUF3452	83..210	CDD:288762	18/128 (14%)
		RB_A	380..536	CDD:280101	42/176 (24%)
		CYCLIN	564..679	CDD:294043	39/119 (33%)
Rb1	NP_033055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		DUF3452	112..219	CDD:371807	24/154 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..360		4/18 (22%)
		Pocket, binds T and E1A. /evidence=ECO:0000250	367..764		93/436 (21%)
		Domain A. /evidence=ECO:0000250	367..573		46/206 (22%)
		RB_A	367..567	CDD:366846	45/200 (23%)
		Spacer. /evidence=ECO:0000250	574..632		5/57 (9%)
		Domain B. /evidence=ECO:0000250	633..764		42/169 (25%)
		RB_B	639..758	CDD:366845	39/141 (28%)
		Interaction with LIMD1. /evidence=ECO:0000250	756..921		16/98 (16%)
		Rb_C	761..917	CDD:370194	15/74 (20%)
		Domain, mediates interaction with E4F1. /evidence=ECO:0000250	764..921		15/55 (27%)
		Bipartite nuclear localization signal. /evidence=ECO:0000269\|PubMed:8336704	853..869
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	872..921
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850