DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbf2 and rb1

DIOPT Version :9

Sequence 1:	NP_524372.1	Gene:	Rbf2 / 41941	FlyBaseID:	FBgn0038390	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	NP_001269454.1	Gene:	rb1 / 100493114	XenbaseID:	XB-GENE-1018165	Length:	900	Species:	Xenopus tropicalis

Alignment Length:	894	Identity:	190/894 - (21%)
Similarity:	339/894 - (37%)	Gaps:	231/894 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FSVSCEQLELEARIQQSALSTYHRLDAVNGLSTSEADAQEWL--CCAVYSELQRSKMR-DIRESI 78
            |:|.||.|::...::..|..||.::.: :|....||..:..|  .|...:.:...:|. ...|.:
Frog    30 FNVLCETLKISNNVRDKAWKTYEKIFS-SGYMMREATKKTELLGLCLYIASVDCEEMTFTFTELL 93

  Fly    79 NEANDSVAKNCCWNVSLTRLLRSFKMN-----------VSQFLRRMEHWNWLTQN-ENTFQLEVE 131
            .....||::  |:     ||||...:|           :|:..::.|....|.|. :.||::..|
Frog    94 KTLTLSVSR--CF-----RLLREMDINMDVLSNKVDNAISKLKKKYETMCLLYQKFQRTFEIIFE 151

  Fly   132 ELRCRLGI--TSTLLRHYKHIFRSLFVHPGKGADPGAANHYQALYEFGWLLFLVIRNELPGFAIT 194
            |....|..  |:::|               ||.               |:.||:.|.::.... .
Frog   152 EQHNTLASVDTASIL---------------KGT---------------WITFLLARGKILQMD-D 185

  Fly   195 NLINGCQVLVCTMDLLF---------------VNALEV---PRSVVIRREFSGVPKNWDTEDFNP 241
            :|:..||:|:|.:|...               :|||.|   |||  .||.     :|.:|.. :|
Frog   186 DLVISCQLLLCVLDYFIKLSPPSVLKEPYKSALNALSVNTPPRS--SRRS-----QNRNTRS-SP 242

  Fly   242 ILLNKYSVLEALGELIPELPAK----GVVQMKNAFFHKALIMLYMDHSLVGDDTHMREIIKEGML 302
            .......|||.|        .|    .:.::||.:....:..|    :..|..:      .||..
Frog   243 QSETDIKVLEIL--------CKENHCPMDEVKNVYCTSFVDFL----ASAGISS------SEGFP 289

  Fly   303 DINLENLNRKYTNQVADISEMDERVLL--------SVQGAIETKGDSPKS---------PQLAFQ 350
            .:  |:::::|........::|.|:.|        .||.:::.:....|.         ||..|:
Frog   290 KV--ESISQQYEELYHKYKDLDARLFLENEETLKADVQDSLDLERTPRKDESEEVSIVPPQTPFR 352

  Fly   351 TSSSPSHRKLSTHDLPASLPLSIIKAFPKKEDADKIVNYLDQTLEEMNRTFTMAVKDF------- 408
            .:.:..|:...|.:..:..|            :||:.:|.:..........|..|:.|
Frog   353 AAMNTIHQLTVTLNSASDNP------------SDKLNSYFNNCTVNPKTKVTERVEHFGHVFKEK 405

  Fly   409 -------LDAELSGKRFRQARGLYYKYLQKILGPELVQKPQLKIGQLMKQRKLTAALLACCLELA 466
                   ..||:..||::....|||:.::.||..|..:.......:|:........||||.:|:.
Frog   406 FASSVGQACAEIGYKRYKLGVRLYYRVMEAILKTEEERLSVHNFSKLLNNDIFHMCLLACAVEVV 470

  Fly   467 L--------HVHHKLVEGLRFPFVLHCFSLDAYDFQKILELVVRYDHGFLGRELIKHLDVVEEMC 523
            :        ..:......|.||::|..|.:.|:||.|::|..::.:.. |..::||:|:..|...
Frog   471 IDSYTRNTAQAYFSSRTNLSFPWILRVFEIKAFDFYKVIECFIKAEPS-LTSDMIKYLERCEHQI 534

  Fly   524 LDSLIFRKSSQLWWELNQRLPRYKEVD-------------------------------------- 550
            ::||.::..|.|:..:.|...|...||
Frog   535 MESLAWQSDSPLFDLIRQTREREGLVDHPELVSTLQQPVQHNHTAADLYLSPSRSSHQCPVTSVR 599

  Fly   551 ---------AETEDKENFSTGSSICLRKFYGLANRRLLLLCKSLCLVDSFPQ----IWHLAEHSF 602
                     :.::..:..||..|:..:|.|.||.:||..||.|  |:...|:    ||.|.:|:.
Frog   600 TSSVTNGQVSPSQPVQQKSTSLSLFYKKVYLLAYKRLSSLCSS--LLSDHPELEQVIWTLLQHTL 662

  Fly   603 TLESSRLLRNRHLDQLLLCAIHLHVRLEKLHLTFSMIIQHYRRQPHFRRSAYREVSLGNGQTADI 667
            ..| ..|:|:|||||:::|:::...:.:.:.|.|..|:..|:...:..:..::.|.:.:||...|
Frog   663 QHE-YELMRDRHLDQIMMCSMYGICKAKNIDLRFKTIVTAYKGLTNTNQETFKHVLIRDGQHDSI 726

  Fly   668 ITFYNSVYVQSMGN----YG--RHLECAQTRKSLEESQSNVGILTETTSNELSMRANISISSPPP 726
            |.|||.|::|.:.:    ||  ||...:.. ..:..|....|       |...:..||.:|....
Frog   727 IVFYNLVFMQKLKSHILQYGSARHPTLSPI-PHIPRSPYRFG-------NSPKVPGNIYVSPLKT 783

  Fly   727 PRVCQSGSCSSHPPSSPAASPLSLQS---SPNVKRAASSNDLMREIKRP 772
            |.....|..|....:...:..:||..   ||:  |....|.::...:||
Frog   784 PYKTTDGLLSPSKMTPKTSFLISLGETFRSPD--RFQKINQMLNSCERP 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf2	NP_524372.1	DUF3452	83..210	CDD:288762	31/140 (22%)
		RB_A	380..536	CDD:280101	40/177 (23%)
		CYCLIN	564..679	CDD:294043	39/118 (33%)
rb1	NP_001269454.1	DUF3452	99..200	CDD:371807	30/138 (22%)
		RB_A	349..550	CDD:366846	45/213 (21%)
		RB_B	620..739	CDD:366845	39/121 (32%)
		Rb_C	742..896	CDD:370194	21/99 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010