DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbf2 and rbl2

DIOPT Version :9

Sequence 1:	NP_524372.1	Gene:	Rbf2 / 41941	FlyBaseID:	FBgn0038390	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	XP_002937369.2	Gene:	rbl2 / 100490373	XenbaseID:	XB-GENE-1012835	Length:	1089	Species:	Xenopus tropicalis

Alignment Length:	1095	Identity:	221/1095 - (20%)
Similarity:	395/1095 - (36%)	Gaps:	379/1095 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVEGE---AETLVR-RFSVSCEQLELEARIQQSALSTYHRLDAVNGLSTSEADAQEWLCCAVYSE 65
            |.|||   ||..:| |:...|..|.::.|.:..|...|.|   ::...|.|.:|..||.|::|..
Frog     6 EEEGEGKQAEEQLRCRYDELCSSLNMDERARGEAWEYYSR---ISQNYTLEGNALHWLACSLYVA 67

  Fly    66 LQRSKMRDIRESINEANDSVAKNCCWNVSLTRLLRSFKMNVSQFLRRMEHWNWLTQNENTFQLEV 130
            . |..:..:.....|.|         .||||::|.|.::::.:|..:::.|..:......|:...
Frog    68 C-RQTVPTVGRGTVEGN---------YVSLTQILSSSELSLIEFFNKIKKWEDMANLPTEFRTRT 122

  Fly   131 EELRCRLGITSTLLRHYKHIFRSLFVHPGKGADPGAANH-----------YQALYEFGWLLFLVI 184
            ::|.....:::.|.:.|..||:.:|..|   .:.....|           ...:|:|.|:||:..
Frog   123 KKLERNFTVSAVLFKKYDPIFQEVFRSP---LEEQPRQHRGRKQRRQPCTVSEVYQFCWVLFIHT 184

  Fly   185 RNELPGFAITNLINGCQVLVCTMDLLFVNALEVP-RSVVIRREFSGVPKNWDTEDFN-PILLNKY 247
            :...|..: .:|:|...:|:|.:||::.|||:.| |..::...|.|:|:::.:.::. |  |...
Frog   185 KGNFPMIS-DDLVNSYHLLLCALDLVYGNALQCPNRRELLNPNFQGLPEDFCSREYKAP--LEAP 246

  Fly   248 SVLEALGELIP--ELPAKGVVQMKNAFFHKALIMLYMDHSLVGDDTHMREIIKEGMLDINLENLN 310
            .::|.|..|..  .|.|||:   |..|:...:..|:....|.|....:...:..|....:::.:|
Frog   247 CIIETLCGLHDGLVLEAKGI---KEHFWKPYIRKLFDKKILKGKSDSLVGFLDPGNFADSVKAIN 308

  Fly   311 RKYTNQVADISEMDERVLL---------------------SVQGA-----IETKGDSPKSPQLAF 349
            :.|...|.....:||||.:                     ||:.|     ::...|..||.:::.
Frog   309 KAYEGYVLSAGNLDERVFMEDVEEEIGRIGQCLNPSLGMESVERAKVTYNLQQNFDKFKSLRVST 373

  Fly   350 QTSSSPSHRKLSTHDLPASLPLS-----------IIKAFPKKEDADKIVNYL-----DQT----- 393
            ..:|....|:.|    |.:.|:|           |:..| |...:::::..|     |.|
Frog   374 PLTSLKYIRECS----PCTTPISSAMYCVSRLFTILTGF-KPAPSERLLQMLRSCSRDPTKTILR 433

  Fly   394 -LEEMNRTF-----TMAVKDFLDAELSGKRFRQARGLYYKYLQKILGPELVQKPQLKIGQLMKQR 452
             |:||:.||     ::|.|.|. .:::.|.||.|..||||.|:.::..|..:...:.:..:::|.
Frog   434 RLKEMSETFCENTDSVAEKQFC-RDITKKYFRLAEVLYYKVLESVIDQEKKRLGDIDMSSILEQD 497

  Fly   453 KLTAALLACCLELALHVHHKLVEGLRFPFVLHCFSLDAYDFQKILELVVRYDHGFLGRELIKHLD 517
            ....:|::||||:.:..:..  .| .||.::..|.|..|.|.|::|:|::.:.| |.||::|||:
Frog   498 VFHRSLMSCCLEITVFSYKP--PG-NFPSIIVMFELAPYQFYKVIEVVIKAEEG-LCREVVKHLN 558

  Fly   518 VVEEMCLDSLIFRKSSQLWWELNQ---RLPRYKEV------------------------------ 549
            .:||..|:.:.:...|.||.::.:   ::|..:||
Frog   559 NIEEQILECMAWTHDSPLWDKIRENDGKIPLCEEVLHPQHFEKSGDNGTTGSLTPRRINEIRADA 623

  Fly   550 ----------------------------------DAETE-------------------------- 554
                                              |:.:|
Frog   624 SGLGRSVPSSPATLCDRYSSPAAGTARRRLFVDPDSSSEAGSPAQASPLATDTVATPPVPGQTLV 688

  Fly   555 ----------------------------------------------------------------- 554

Frog   689 TMATATVTANNGQTVTIPVQGIANENGGITFFPVQVNVSSQPHSVTSSVPPLTAQALAGPLNPQQ 753

  Fly   555 -----------------DKENFST----GSSICL--RKFYGLANRRLLLLCKSLCLVDSF-PQIW 595
                             .|:|.::    .||:.|  |:.|.||:.||..||..|.:.|.. .:||
Frog   754 IQGQVSVSQVPASPGQQSKQNLTSKLKKASSLTLFCRRVYCLASIRLKDLCLKLDISDELRRKIW 818

  Fly   596 HLAEHSFTLESSRLLRNRHLDQLLLCAIHLHVRLEKLHLTFSMIIQHYRRQPHFRRSAYREVSL- 659
            ...|.|. :....|:::|||||||:||:::..::.|...:|..|::.||.|||.....||.|.|
Frog   819 TCFEFSL-VHCPELIKDRHLDQLLMCAVYVITKVTKEDTSFHNIMKCYRVQPHASSHVYRSVLLK 882

  Fly   660 -----------------------------------------------------------GNG--- 662
                                                                       |:.
Frog   883 KRRRRQSGSSDHILQPGSPAENTKDICSREPSPVMRSSSTLPVPQPNSAPPTPTRITAAGSNFVE 947

  Fly   663 -QTADIITFYNSVYVQSMGNYGRHLECAQTRKSLEESQSNVGILTETTSNELSMRANISISSPPP 726
             :..|::.|||::|::.:.::           ::..||||       ||....:....||.:..|
Frog   948 EERGDLVQFYNNIYIEKIKSF-----------AMRFSQSN-------TSEATPLSPYPSIRAVSP 994

  Fly   727 PRV----CQSGSCSSHPPSSPAASPLS-----LQSSPNVKRAASSNDLMREIKRP 772
            .|:    ..|...|:|...:....|..     ...|| .||....|.::|..:.|
Frog   995 RRIQLSHIHSIYVSTHNDDATTVCPREKICYYFDLSP-AKRLQEINSMIRTGETP 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf2	NP_524372.1	DUF3452	83..210	CDD:288762	28/137 (20%)
		RB_A	380..536	CDD:280101	48/171 (28%)
		CYCLIN	564..679	CDD:294043	44/181 (24%)
rbl2	XP_002937369.2	DUF3452	78..209	CDD:371807	30/143 (21%)
		RB_A	389..580	CDD:366846	55/196 (28%)
		Atrophin-1	604..>773	CDD:367360	2/168 (1%)
		RB_B	784..966	CDD:366845	44/182 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	1	1.000	-	-		FOG0002362
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13742
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110