DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbf2 and rbl2

DIOPT Version :9

Sequence 1:	NP_524372.1	Gene:	Rbf2 / 41941	FlyBaseID:	FBgn0038390	Length:	783	Species:	Drosophila melanogaster
Sequence 2:	XP_002667000.3	Gene:	rbl2 / 100331892	ZFINID:	ZDB-GENE-061109-2	Length:	1079	Species:	Danio rerio

Alignment Length:	1005	Identity:	230/1005 - (22%)
Similarity:	370/1005 - (36%)	Gaps:	313/1005 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EAETLVR---RFSVSCEQLELEARIQQSALSTYHRLDAVNGLSTSEADAQEWLCCAVYSELQRSK 70
            |.:||.:   .|...|..|.::......|..:|..:.....|..||.   .||.|::|... ||.
Zfish     4 EEDTLGKTKHAFEELCRDLNMDEESSNRAWRSYENISKNYTLEGSEL---HWLACSLYVAC-RSS 64

  Fly    71 MRDIRESINEANDSVAKNCCWNVSLTRLLRSFKMNVSQFLRRMEHWNWLTQNENTFQLEVEELRC 135
            :..:.:...|.|         .|||||:|||.:.::.:|..:|:.|..:......||...|:|..
Zfish    65 VPTMSKGTAEGN---------YVSLTRILRSSQQSLIEFFSKMKKWQDMANLPRDFQQSTEKLER 120

  Fly   136 RLGITSTLLRHYKHIFRSLFVHPGKGADPGAANH-----------YQALYEFGWLLFLVIRNELP 189
            ...:||.:.:.|..:||.:|..|   .|.....|           ...::.|.|:||:..:...|
Zfish   121 NFTVTSVIFKKYLPLFRDIFKTP---TDELPRTHRGRKQRRHPCTVTEVFNFCWILFIHAKGNFP 182

  Fly   190 GFAITNLINGCQVLVCTMDLLFVNALEV-PRSVVIRREFSGVPKNWDTEDFNPILLNKYSVLEAL 253
            ..: .:|:|...:|:|.:||::.|||.. .|..::...|.|:|::::::|:.| .......:|.|
Zfish   183 MIS-DDLVNSYHLLLCALDLVYCNALLCSSRKDLLNPAFKGLPEDFNSKDYKP-GPGSLCFIEQL 245

  Fly   254 GELIP--ELPAKGVVQMKNAFFHKALIMLYMDHSLVGDDTHMREIIKEGMLDINLENLNRKYTNQ 316
            .||..  .|.|||.   |..|:...:..|:....|.|.:..:...::......:|.:|||.|...
Zfish   246 CELHDGLVLEAKGA---KEHFWKPFIKKLFERKILKGKEDTLTGFLEPVNFGDSLASLNRVYEEH 307

  Fly   317 VADISEMDERVLLSVQGAIETKG-----------DSPKSPQLAFQTSSSPSHRKLST-----HDL 365
            |.....:|||:.|. .||.|..|           |...:|   .|.|.:.|..::||     ..:
Zfish   308 VLSSGSLDERIFLG-DGAREDIGTPGPYEGIENQDRANNP---LQNSMTASALRVSTPLTGRRYV 368

  Fly   366 PASL---PLS-----------IIKAFPKKEDADKIVNYL-----DQT------LEEMNRTF---- 401
            |.|:   |:|           ::..| |...:.|:.:..     |.|      |:||:..|
Zfish   369 PESIVGTPVSSAMQSVGRLHTLLTGF-KYRPSVKLRDIFRSCVRDPTESVAARLKEMSEIFLQNY 432

  Fly   402 --TMAVKDFLDAELSGKRFRQARGLYYKYLQKILGPELVQKPQLKIGQLMKQRKLTAALLACCLE 464
              |......|..:::.|.|..|..||||.|:.|:..|..:...:.:..:::|.....:|:|||||
Zfish   433 EGTGDDNKSLARDIAVKYFCLAEALYYKSLEVIINQEKKRLGDVDLSGVLEQDVFHRSLIACCLE 497

  Fly   465 LALHVHHKLVEGLRFPFVLHCFSLDAYDFQKILELVVRYDHGFLGRELIKHLDVVEEMCLDSLIF 529
            :.:..:....|   ||.||..|.|.||.|.|::|::||.:.| |.||::|||:.|||..|:||.:
Zfish   498 IVIFSYRPPGE---FPRVLQIFDLPAYHFYKVIEVLVRAEEG-LFREVVKHLNHVEEQVLESLAW 558

  Fly   530 RKSSQLWWEL-------------------------NQRLP------------------------- 544
            :.:|.||..:                         |...|
Zfish   559 KGNSPLWERIREAKNCVPTCQEVMPPQHLEDGSGSNANTPSSKTEFSGNIAAGAGKGVSPSPTSL 623

  Fly   545 --RYKE-----------VDAET------------------------------------------- 553
              ||..           ||.:|
Zfish   624 HDRYSSPPTGTAVRRLFVDGDTTPEPAPPVKVAPPSIVSSIPAGQTVVTMATATVTANNGQTVTI 688

  Fly   554 --------------------------------------------------------------EDK 556
                                                                          :||
Zfish   689 PVQGIANESGGITFIPVQVSVTSQAGATLPTLSAQTLTGTLTTQQLTTTPMGAVQNNPSPPKQDK 753

  Fly   557 ENFSTGS---------SICL--RKFYGLANRRLLLLCKSLCL-VDSFPQIWHLAEHSFTLESSRL 609
            :....|:         |:||  ||.|.||:.||..||..|.: .|...:||...|:|. :..:.|
Zfish   754 KTPQQGTPTKRAQKTGSLCLFFRKVYHLASVRLRDLCAKLDISADLRRKIWTCFEYSL-VHCTDL 817

  Fly   610 LRNRHLDQLLLCAIHLHVRLEKLHLTFSMIIQHYRRQPHFRRSAYREVSLGNGQTADIITFYNSV 674
            :.:|||||||:|||::..::.|...:|..|::.||.||....|.||.|.:.
Zfish   818 MMDRHLDQLLMCAIYVMTKVTKEDKSFQNIMKCYRSQPQASSSVYRSVLIS-------------- 868

  Fly   675 YVQSMGNYGRHLECAQTRKSLEESQSNVGILTETT--SNELSMRANISISSPPPPRVCQSGSCSS 737
                 |...||  ...|..:..:|....|...:.:  |:.:|||::.::..|.|          |
Zfish   869 -----GRKRRH--SGNTENTHRQSSPTEGAQEQASGESSPVSMRSSSTLPIPQP----------S 916

  Fly   738 HPPSSPAASPLSLQSSPNVKRAASSNDLMR 767
            ..||:|..:|...|     ::.....||:|
Zfish   917 SAPSTPTRAPGGPQ-----EQEEERGDLIR 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbf2	NP_524372.1	DUF3452	83..210	CDD:288762	34/137 (25%)
		RB_A	380..536	CDD:280101	54/172 (31%)
		CYCLIN	564..679	CDD:294043	40/117 (34%)
rbl2	XP_002667000.3	DUF3452	70..202	CDD:288762	36/144 (25%)
		RB_A	375..568	CDD:280101	60/197 (30%)
		RB_B	770..951	CDD:280100	61/209 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580911
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1010
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46367
OrthoDB	1	1.010	-	-		D113612at2759
OrthoFinder	1	1.000	-	-		FOG0002362
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.820