DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and GRR1

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_012623.1	Gene:	GRR1 / 853552	SGDID:	S000003850	Length:	1151	Species:	Saccharomyces cerevisiae

Alignment Length:	640	Identity:	127/640 - (19%)
Similarity:	224/640 - (35%)	Gaps:	212/640 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 KMESLYLGNA------------LRTLPLGAEASQFQNERY----YLEDYSSGSGNERLPERLH-- 274
            |::.|.:.|:            :|...|..|..:.:|.|.    .:|:|.         :.|:
Yeast   190 KLKELRIDNSPQAISYLHKLQRMRLRALETENMEIRNLRLKILTIIEEYK---------KSLYAY 245

  Fly   275 -HPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCNLGRFSPSLDQGYATLVSPSPTGHH 338
             |.:.......:.:|.:::..:|...   ::...|.:||.:|.|:|    :.:...|..:|:..
Yeast   246 CHSKLRGQQVENPTDNFIIWINSIDT---TESSDLKEGLQDLSRYS----RQFINNVLSNPSNQ- 302

  Fly   339 SSGGAGNVTNSTTASGAGIMASSTPTTTPRRGASSNGLGGGAASAIGPPPWNRKGPFRCGPLF-- 401
                  |:..|.|                                            |..|:|
Yeast   303 ------NICTSVT--------------------------------------------RRSPVFAL 317

  Fly   402 DRLPDEAVVRIFSWL----DSCELCNVARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFR 462
            :.||.|.:..|...|    |..:...|:::        |..|:.|::..| .|:|....|.:..|
Yeast   318 NMLPSEILHLILDKLNQKYDIVKFLTVSKL--------WAEIIVKILYYR-PHINKKSQLDLFLR 373

  Fly   463 QLCGQSCNGACPEVERVMLADGCRISDKGLQLLTRR--------------------CPELTHLQL 507
            .:       .....|.|.          ..:|:.:|                    |..|..|.|
Yeast   374 TM-------KLTSEETVF----------NYRLMIKRLNFSFVGDYMHDTELNYFVGCKNLERLTL 421

  Fly   508 QTCVDITNQALVEALTKCSNLQHLDVTGCSQVSS------ISPNPHME----PPRR--------- 553
            ..|..||:..:...|..|..||.:|:||...||.      .:..|.::    |..|
Yeast   422 VFCKHITSVPISAVLRGCKFLQSVDITGIRDVSDDVFDTLATYCPRVQGFYVPQARNVTFDSLRN 486

  Fly   554 -----LLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSV 613
                 .:|:.:.:|....::|..::::...||.||.:.:.....|||:.|..:.:..|.|:|..:
Yeast   487 FIVHSPMLKRIKITANNNMNDELVELLANKCPLLVEVDITLSPNVTDSSLLKLLTRLVQLREFRI 551

  Fly   614 SDCLNITDFGLYELAKL---GAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDS 675
            :...||||....||:|:   ..:||.:.::.||.::|..::.|.....|||.:....|..::|.|
Yeast   552 THNTNITDNLFQELSKVVDDMPSLRLIDLSGCENITDKTIESIVNLAPKLRNVFLGKCSRITDAS 616

  Fly   676 ITVLARSCPRLRALDIGKC-DVSDAGLRALAESC-------------------------PNLKKL 714
            :..|::....|:.:..|.| :::|.|:|||..||                         |.||::
Yeast   617 LFQLSKLGKNLQTVHFGHCFNITDNGVRALFHSCTRIQYVDFACCTNLTNRTLYELADLPKLKRI 681

  Fly   715 SLRSCDMITDRGVQCIAYYCRGLQQLNIQDCPVSIEG-----YRAVKKYCKRCII 764
            .|..|..:||.|:            ||:    ||:.|     .|....||....|
Yeast   682 GLVKCTQMTDEGL------------LNM----VSLRGRNDTLERVHLSYCSNLTI 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	11/51 (22%)
		leucine-rich repeat	441..460	CDD:275381	5/18 (28%)
		AMN1	<451..595	CDD:187754	34/187 (18%)
		leucine-rich repeat	476..501	CDD:275381	5/44 (11%)
		leucine-rich repeat	502..521	CDD:275381	6/18 (33%)
		leucine-rich repeat	528..555	CDD:275381	10/50 (20%)
		leucine-rich repeat	556..581	CDD:275381	4/24 (17%)
		AMN1	577..746	CDD:187754	51/197 (26%)
		leucine-rich repeat	582..607	CDD:275381	6/24 (25%)
		leucine-rich repeat	608..633	CDD:275381	9/27 (33%)
		leucine-rich repeat	634..659	CDD:275381	6/24 (25%)
		leucine-rich repeat	660..685	CDD:275381	6/24 (25%)
		leucine-rich repeat	686..710	CDD:275381	10/49 (20%)
		leucine-rich repeat	711..735	CDD:275381	7/23 (30%)
		leucine-rich repeat	737..761	CDD:275381	8/28 (29%)
GRR1	NP_012623.1	F-box-like	320..361	CDD:403981	11/49 (22%)
		AMN1	404..559	CDD:187754	35/154 (23%)
		leucine-rich repeat	416..441	CDD:275381	8/24 (33%)
		leucine-rich repeat	442..467	CDD:275381	7/24 (29%)
		leucine-rich repeat	494..519	CDD:275381	4/24 (17%)
		leucine-rich repeat	520..545	CDD:275381	6/24 (25%)
		leucine-rich repeat	546..574	CDD:275381	9/27 (33%)
		AMN1	<574..737	CDD:187754	40/163 (25%)
		leucine-rich repeat	575..600	CDD:275381	6/24 (25%)
		leucine-rich repeat	601..626	CDD:275381	6/24 (25%)
		leucine-rich repeat	627..652	CDD:275381	10/24 (42%)
		leucine-rich repeat	653..677	CDD:275381	0/23 (0%)
		leucine-rich repeat	678..704	CDD:275381	12/41 (29%)
		leucine-rich repeat	707..732	CDD:275381	4/14 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46756
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840