Protein Alignment Fbxl7 and FBXL20

DIOPT Version :9

• Sequence 1: NP_650512.1
• Gene: Fbxl7 / 41935
• FlyBaseID: FBgn0038385
• Length: 772
• Species: Drosophila melanogaster
• Sequence 2: NP_001357137.1
• Gene: FBXL20 / 84961
• HGNCID: 24679
• Length: 473
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 139/507 - (27%)
• Similarity: 220/507 - (43%)
• Gaps: 116/507 - (22%)

  Fly   338 HSSGGAGNVTNSTTASGAGIMASSTPTTTPRRGASSNGLGGGAASAIGPPPWNRKGPFRCGPLFD 402
            |..||.|                         |....|..||||:|..|...:.:...:..|..|
Human     2 HWGGGGG-------------------------GGGGGGNRGGAAAAALPQSRHIQKRRKMAPSRD 41

  Fly   403 R----------------------LPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVIS 445
            |                      ||.|.::||||:||...||..|:|.|.:..||.....|:.|.
Human    42 RLLHFGFKATMFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRID 106

  Fly   446 L-------RGEHL-NGDKTLKMIFRQLCGQSCNGA-----------CPEVERVMLADGC-RISDK 490
            |       .|..: |..|......|:|..:.|.|.           |..:| |:..:|| :.:|.
Human   107 LFDFQRDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIE-VLNLNGCTKTTDA 170

  Fly   491 GLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEPPRRLL 555
            ....|::.|.:|.||.|.:|..|||.:|......|..|:.|:::.|.||:.       :..:.|:
Human   171 TCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTK-------DGIQALV 228

  Fly   556 -----LQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSD 615
                 |:.|.|..|..::|..||.:..:||:||.|.|:.|:|:||.||..:...|..|:.|..|.
Human   229 RGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASG 293

  Fly   616 CLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLA 680
            |.||||..|..|.:....||.|.||:|.:::|.|...:||.|::|..::...|..::|.::..|:
Human   294 CSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLS 358

  Fly   681 RSCPRLRALDIGKCD-VSDAGLRALAE-SCPN--LKKLSLRSCDMITDRGVQCIAYYCRGLQQLN 741
            ..||||:.|.:..|: ::|.|:|.|.. :|.:  |:.:.|.:|.:|||..::.:. .|..|:::.
Human   359 IHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLK-SCHSLERIE 422

  Fly   742 IQDC-----------------------------PVSIEGYRAVKKYCKRCII 764
            :.||                             |.|:.|.|  :::|:.|||
Human   423 LYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSR--QRFCRCCII 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	21/74 (28%)
		leucine-rich repeat	441..460	CDD:275381	6/26 (23%)
		AMN1	<451..595	CDD:187754	45/161 (28%)
		leucine-rich repeat	476..501	CDD:275381	7/25 (28%)
		leucine-rich repeat	502..521	CDD:275381	9/18 (50%)
		leucine-rich repeat	528..555	CDD:275381	5/26 (19%)
		leucine-rich repeat	556..581	CDD:275381	8/24 (33%)
		AMN1	577..746	CDD:187754	59/201 (29%)
		leucine-rich repeat	582..607	CDD:275381	11/24 (46%)
		leucine-rich repeat	608..633	CDD:275381	10/24 (42%)
		leucine-rich repeat	634..659	CDD:275381	11/24 (46%)
		leucine-rich repeat	660..685	CDD:275381	5/24 (21%)
		leucine-rich repeat	686..710	CDD:275381	8/25 (32%)
		leucine-rich repeat	711..735	CDD:275381	6/23 (26%)
		leucine-rich repeat	737..761	CDD:275381	8/52 (15%)
FBXL20	NP_001357137.1	F-box-like	64..106	CDD:338561	17/41 (41%)
		leucine-rich repeat	102..129	CDD:275381	6/26 (23%)
		AMN1	130..326	CDD:355707	64/203 (32%)
		leucine-rich repeat	130..149	CDD:275381	4/18 (22%)
		leucine-rich repeat	156..181	CDD:275381	7/25 (28%)
		leucine-rich repeat	182..207	CDD:275381	10/24 (42%)
		leucine-rich repeat	208..233	CDD:275381	6/31 (19%)
		leucine-rich repeat	234..259	CDD:275381	8/24 (33%)
		AMN1	257..431	CDD:355707	59/174 (34%)
		leucine-rich repeat	260..285	CDD:275381	11/24 (46%)
		leucine-rich repeat	286..311	CDD:275381	10/24 (42%)
		leucine-rich repeat	312..337	CDD:275381	11/24 (46%)
		leucine-rich repeat	338..363	CDD:275381	5/24 (21%)
		leucine-rich repeat	364..392	CDD:275381	8/27 (30%)
		leucine-rich repeat	393..417	CDD:275381	7/24 (29%)
		leucine-rich repeat	418..443	CDD:275381	3/24 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940