DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and KDM2B

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_011537169.1	Gene:	KDM2B / 84678	HGNCID:	13610	Length:	1353	Species:	Homo sapiens

Alignment Length:	718	Identity:	156/718 - (21%)
Similarity:	228/718 - (31%)	Gaps:	204/718 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ECPLAS-LGRNSNAVRDH----YHHPHPLSSSPLDPQAYKMMSRKSPNPG---LEVAEALASRS- 69
            |||..: .|:...|.:..    :.:...|..|.|..|.....:::...|.   .|..||...||
Human   718 ECPKCNHAGKTGKAYKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSD 782

  Fly    70 ----STPPSDQAGASSTAAAAAVLHMVQQKAATFELRGRHSRPTEQQTSYGAHSTASVGRHAKKS 130
                ..||.   |.....:....|...::.....||.|| .|.:..|||.|:.|      |....
Human   783 EHSKKVPPD---GLLRRKSDDVHLRKKRKYEKPQELSGR-KRASSLQTSPGSSS------HLSPR 837

  Fly   131 PELPAPASRNVAPVPQPRNFLT-LEHVLQ-------FGTQRPSWMHGN-------------SADT 174
            |.|.:..|      |..|:.|| .:..|:       |..:|.||.:..             ..:.
Human   838 PPLGSSLS------PWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEP 896

  Fly   175 EDSSDNNAGGGGAGSGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALR 239
            ||....            .....|.:...|.|.||.    |....||:...:||...:.....|.
Human   897 EDELPE------------APPKTRESDHSRSSSPTA----GPSTEGAEGPEEKKKVKMRRKRRLP 945

  Fly   240 TLPLGAEASQFQNERYYLEDYSSGSGNERLPERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSK 304
            ...|..|.|:..|......:.|..:.|::       |..|.| |:.|.:
Human   946 NKELSRELSKELNHEIQRTENSLANENQQ-------PIKSEP-ESEGEE---------------- 986

  Fly   305 GQSLSDGLCNL-GRFSPSLDQGYATLVSPSPTGHHSSGGAGNVTNSTTASGAGIMASSTPTTTPR 368
             .....|:|.. .|||..|:.      :|....|.        ...:..|...:::...|:.:|.
Human   987 -PKRPPGICERPHRFSKGLNG------TPRELRHQ--------LGPSLRSPPRVISRPPPSVSPP 1036

  Fly   369 RGASSNGLGGGAASAIGPPPWNRKGPFRCGPLFDRLP----------DEAVVRIFSWLDSCELCN 423
            :.....      ...|.|||        ..|..|.||          .|..:.:||:|...:||.
Human  1037 KCIQME------RHVIRPPP--------ISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCV 1087

  Fly   424 VARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCR-- 486
            ..||||.:........||..|.|  .|                      |..:..:||:...|
Human  1088 CMRVCRTWNRWCCDKRLWTRIDL--NH----------------------CKSITPLMLSGIIRRQ 1128

  Fly   487 ----------ISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSS 541
                      ||.|.|..|..|.|.|..|.|..|..|...||..  :.|..|:.|||.....:..
Human  1129 PVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCS--SSCPLLRTLDVQWVEGLKD 1191

  Fly   542 ISPNPHMEPPR-----------------RLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRR 589
            ......:.||.                 .|.|..||:||.      .|::::::.|.|..|:|..
Human  1192 AQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDA------SLRLIIRHMPLLSKLHLSY 1250

  Fly   590 CIQVTDAGLKFVPSFCV----SLKELSVSDCLNITDFGLYELAKLG----AALRYLSVAKCERVS 646
            |..|||..:..:.:...    ||.|:::|||..:||..|....:.|    ..|||     |::|:
Human  1251 CNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRY-----CKQVT 1310

  Fly   647 DAG 649
            ..|
Human  1311 KEG 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	16/55 (29%)
		leucine-rich repeat	441..460	CDD:275381	4/18 (22%)
		AMN1	<451..595	CDD:187754	38/172 (22%)
		leucine-rich repeat	476..501	CDD:275381	9/36 (25%)
		leucine-rich repeat	502..521	CDD:275381	7/18 (39%)
		leucine-rich repeat	528..555	CDD:275381	6/43 (14%)
		leucine-rich repeat	556..581	CDD:275381	6/24 (25%)
		AMN1	577..746	CDD:187754	24/81 (30%)
		leucine-rich repeat	582..607	CDD:275381	7/28 (25%)
		leucine-rich repeat	608..633	CDD:275381	9/28 (32%)
		leucine-rich repeat	634..659	CDD:275381	6/16 (38%)
		leucine-rich repeat	660..685	CDD:275381
		leucine-rich repeat	686..710	CDD:275381
		leucine-rich repeat	711..735	CDD:275381
		leucine-rich repeat	737..761	CDD:275381
KDM2B	XP_011537169.1	JmjC	182..257	CDD:214721
		cupin_like	229..335	CDD:304367
		zf-CXXC	<615..651	CDD:251032
		PHD_KDM2B	661..722	CDD:277114	3/3 (100%)
		F-box-like	1071..1111	CDD:289689	14/41 (34%)
		leucine-rich repeat	1105..1129	CDD:275381	8/47 (17%)
		AMN1	1121..1310	CDD:187754	52/201 (26%)
		leucine-rich repeat	1130..1153	CDD:275381	6/22 (27%)
		leucine-rich repeat	1154..1177	CDD:275381	8/24 (33%)
		leucine-rich repeat	1178..1217	CDD:275381	6/38 (16%)
		leucine-rich repeat	1218..1242	CDD:275381	7/29 (24%)
		leucine-rich repeat	1243..1272	CDD:275381	7/28 (25%)
		leucine-rich repeat	1273..1297	CDD:275381	8/23 (35%)
		leucine-rich repeat	1298..1323	CDD:275381	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810