DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and VFB3

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_567316.1	Gene:	VFB3 / 826171	AraportID:	AT4G07400	Length:	554	Species:	Arabidopsis thaliana

Alignment Length:	425	Identity:	92/425 - (21%)
Similarity:	162/425 - (38%)	Gaps:	111/425 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 LPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVISLRGEH---LNGDKTLKMIFRQLC 465
            ||||.:..||..|...:|...:.||||          |..|..:..|   |.....|..:...|.
plant    77 LPDECLSLIFQSLTCADLKRCSLVCRR----------WLTIEGQCRHRLSLKAQSDLISVIPSLF 131

  Fly   466 GQSCNGACPEVERVMLADGCR---ISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSN 527
            .:     ...|.:::|....|   |.|....:::.||..||.|:|:.|.:|::..::.....|.:
plant   132 TR-----FDSVTKLVLRSDRRSLGICDNAFVMISVRCRNLTRLKLRGCPEISDLGIIGFTENCRS 191

  Fly   528 LQHLDVTGCSQVSSISPNPHMEPPRRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRR--- 589
            |:.:....|                             .....|:..::..|..|..|.::|
plant   192 LKKVSFGSC-----------------------------GFGVKGMNALLNTCLGLEELSVKRLRG 227

  Fly   590 --------------------CIQVTDAGLKFVP--SFCVSLKELSVSDC---------------- 616
                                |::....|..|.|  |....|:.|.:..|
plant   228 IGAGAELIGPGGAAGSLKVICLKELHNGQCFAPLLSGAKGLRILKIFRCSGDWDRVFEAVRDKVN 292

  Fly   617 ---------LNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEA-- 670
                     :.::|.||..|:|. :.:..|.:.|....::.||.::|.||..||.|:..|.:.
plant   293 AIVEIHLERIQMSDLGLTALSKC-SGVEVLHLVKTPDCTNVGLALVAERCKLLRKLHIDGWKTNR 356

  Fly   671 VSDDSITVLARSCPRLRALDIGKCDVSDAGLRALAESCPNLKKLSLRSCDMITDRGVQCIAYYCR 735
            :.|:.:.|:|:.|..|:.|.:...:.:...|.|:..:|.||::|:|...|.:.|..:.|||..|.
plant   357 IGDEGLIVVAKYCWNLQELVLIGVNPTKLSLEAIVSNCLNLERLALCGSDTVGDTELCCIAEKCL 421

  Fly   736 GLQQLNIQDCPVSIEGYRAVKKYC--------KRC 762
            .|::|.|::||::.:|.:|:...|        |:|
plant   422 ALRKLCIKNCPITDDGIKALGNGCPNLLKVKVKKC 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	14/42 (33%)
		leucine-rich repeat	441..460	CDD:275381	5/21 (24%)
		AMN1	<451..595	CDD:187754	25/169 (15%)
		leucine-rich repeat	476..501	CDD:275381	7/27 (26%)
		leucine-rich repeat	502..521	CDD:275381	6/18 (33%)
		leucine-rich repeat	528..555	CDD:275381	2/26 (8%)
		leucine-rich repeat	556..581	CDD:275381	2/24 (8%)
		AMN1	577..746	CDD:187754	50/220 (23%)
		leucine-rich repeat	582..607	CDD:275381	8/49 (16%)
		leucine-rich repeat	608..633	CDD:275381	8/49 (16%)
		leucine-rich repeat	634..659	CDD:275381	7/24 (29%)
		leucine-rich repeat	660..685	CDD:275381	8/26 (31%)
		leucine-rich repeat	686..710	CDD:275381	5/23 (22%)
		leucine-rich repeat	711..735	CDD:275381	8/23 (35%)
		leucine-rich repeat	737..761	CDD:275381	8/31 (26%)
VFB3	NP_567316.1	F-box-like	74..>104	CDD:289689	12/36 (33%)
		leucine-rich repeat	89..114	CDD:275381	8/34 (24%)
		leucine-rich repeat	115..165	CDD:275381	10/54 (19%)
		AMN1	<146..>226	CDD:187754	19/108 (18%)
		leucine-rich repeat	166..191	CDD:275381	7/24 (29%)
		leucine-rich repeat	192..216	CDD:275381	4/52 (8%)
		leucine-rich repeat	268..293	CDD:275381	3/24 (13%)
		leucine-rich repeat	294..317	CDD:275381	5/23 (22%)
		leucine-rich repeat	318..343	CDD:275381	7/24 (29%)
		AMN1	<340..>463	CDD:187754	35/117 (30%)
		leucine-rich repeat	344..371	CDD:275381	8/26 (31%)
		leucine-rich repeat	372..396	CDD:275381	5/23 (22%)
		leucine-rich repeat	397..422	CDD:275381	9/24 (38%)
		leucine-rich repeat	423..447	CDD:275381	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920