DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxl7 and Fbxl22

DIOPT Version :9

Sequence 1:NP_650512.1 Gene:Fbxl7 / 41935 FlyBaseID:FBgn0038385 Length:772 Species:Drosophila melanogaster
Sequence 2:NP_780415.1 Gene:Fbxl22 / 74165 MGIID:1921415 Length:236 Species:Mus musculus


Alignment Length:330 Identity:71/330 - (21%)
Similarity:110/330 - (33%) Gaps:133/330 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   403 RLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVI------SLRGEHLNGDKTLKMIF 461
            :|..|.::.:||:||.....:::|.|.:...:...|.||.::      .|:.::......|:.: 
Mouse     5 QLNRECLLCLFSFLDKDSRRSLSRTCSQLRDVFEDPTLWPLLHFHSLAELKKDNFRLSPALRSL- 68

  Fly   462 RQLCGQSCNGACPEVERVMLADGCRISDKGLQLLTRR-CPELTHLQLQTCVDITNQALVEALTKC 525
             .:|..|        .||.:   |.|.|.....|.|. |.:  |..|      .|..|::...:|
Mouse    69 -SICWHS--------SRVQV---CSIEDWLKSALQRSICSQ--HESL------VNDFLLQVCNRC 113

  Fly   526 SNLQHLDVTGCSQVSSISPNPHMEPPRRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRC 590
            .||..:.::||..|:.                     ||:|       .::.:||:|..|.|..|
Mouse   114 PNLTSVTLSGCGHVTD---------------------DCLA-------RLLLSCPRLRTLRLENC 150

  Fly   591 IQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIAR 655
            .:||:..|..|                          |..|.||:.|.|..|..||.|||.    
Mouse   151 ARVTNRTLAAV--------------------------AAHGRALQTLHVDFCRNVSAAGLL---- 185

  Fly   656 RCYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIGKCDVSDAGLRALAESCPNLKKLSLRSCD 720
                                         ||||                  :||||:..:.||..
Mouse   186 -----------------------------RLRA------------------ACPNLRLSAERSAA 203

  Fly   721 MITDR 725
            ||.|:
Mouse   204 MIPDQ 208

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl7NP_650512.1 F-box-like 401..447 CDD:289689 11/49 (22%)
leucine-rich repeat 441..460 CDD:275381 3/24 (13%)
AMN1 <451..595 CDD:187754 31/144 (22%)
leucine-rich repeat 476..501 CDD:275381 8/25 (32%)
leucine-rich repeat 502..521 CDD:275381 4/18 (22%)
leucine-rich repeat 528..555 CDD:275381 4/26 (15%)
leucine-rich repeat 556..581 CDD:275381 4/24 (17%)
AMN1 577..746 CDD:187754 35/149 (23%)
leucine-rich repeat 582..607 CDD:275381 8/24 (33%)
leucine-rich repeat 608..633 CDD:275381 2/24 (8%)
leucine-rich repeat 634..659 CDD:275381 9/24 (38%)
leucine-rich repeat 660..685 CDD:275381 0/24 (0%)
leucine-rich repeat 686..710 CDD:275381 4/23 (17%)
leucine-rich repeat 711..735 CDD:275381 6/15 (40%)
leucine-rich repeat 737..761 CDD:275381
Fbxl22NP_780415.1 F-box-like 3..43 CDD:403981 9/37 (24%)
LRR 1 15..40 6/24 (25%)
LRR 2 43..72 3/30 (10%)
AMN1 45..>200 CDD:187754 55/280 (20%)
LRR 3 98..123 7/30 (23%)
leucine-rich repeat 116..141 CDD:275381 8/52 (15%)
LRR 4 124..149 10/52 (19%)
leucine-rich repeat 142..167 CDD:275381 10/50 (20%)
LRR 5 150..175 11/50 (22%)
leucine-rich repeat 168..193 CDD:275381 14/75 (19%)
LRR 6 176..201 14/75 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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