DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and Fbxl20

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_006534361.1	Gene:	Fbxl20 / 72194	MGIID:	1919444	Length:	438	Species:	Mus musculus

Alignment Length:	420	Identity:	124/420 - (29%)
Similarity:	202/420 - (48%)	Gaps:	69/420 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 RLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVISL-------RGEHL-NGDKTLKM 459
            :||.|.::||||:||...||..|:|.|.:..||.....|:.|.|       .|..: |..|....
Mouse    29 KLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGG 93

  Fly   460 IFRQLCGQSCNGA-----------CPEVERVMLADGC-RISDKGLQLLTRRCPELTHLQLQTCVD 512
            ..|:|..:.|.|.           |..:| |:..:|| :.:|.....|::.|.:|.||.|.:|..
Mouse    94 FLRKLSLRGCLGVGDNALRTFAQNCRNIE-VLSLNGCTKTTDATCTSLSKFCSKLRHLDLASCTS 157

  Fly   513 ITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEPPRRLL-----LQYLDLTDCMAIDDMGL 572
            |||.:|......|..|:.|:::.|.||:.       :..:.|:     |:.|.|..|..::|..|
Mouse   158 ITNMSLKALSEGCPLLEQLNISWCDQVTK-------DGIQALVRGCGGLKALFLKGCTQLEDEAL 215

  Fly   573 KIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYL 637
            |.:..:||:||.|.|:.|:|:||.||..:...|..|:.|..|.|.||||..|..|.:....||.|
Mouse   216 KYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRIL 280

  Fly   638 SVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIGKCD-VSDAGL 701
            .||:|.:::|.|...:||.|::|..::...|..::|.::..|:..||||:.|.:..|: ::|.|:
Mouse   281 EVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGI 345

  Fly   702 RALAE-SCPN--LKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQDC------------------ 745
            |.|.. :|.:  |:.:.|.:|.:|||..::.:. .|..|:::.:.||
Mouse   346 RHLGNGACAHDQLEVIELDNCPLITDASLEHLK-SCHSLERIELYDCQQITRAGIKRLRTHLPNI 409

  Fly   746 -----------PVSIEGYRAVKKYCKRCII 764
                       |.|:.|.|  :::|:.|||
Mouse   410 KVHAYFAPVTPPPSVGGSR--QRFCRCCII 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	19/50 (38%)
		leucine-rich repeat	441..460	CDD:275381	6/26 (23%)
		AMN1	<451..595	CDD:187754	45/161 (28%)
		leucine-rich repeat	476..501	CDD:275381	7/25 (28%)
		leucine-rich repeat	502..521	CDD:275381	9/18 (50%)
		leucine-rich repeat	528..555	CDD:275381	5/26 (19%)
		leucine-rich repeat	556..581	CDD:275381	8/24 (33%)
		AMN1	577..746	CDD:187754	59/201 (29%)
		leucine-rich repeat	582..607	CDD:275381	11/24 (46%)
		leucine-rich repeat	608..633	CDD:275381	10/24 (42%)
		leucine-rich repeat	634..659	CDD:275381	11/24 (46%)
		leucine-rich repeat	660..685	CDD:275381	5/24 (21%)
		leucine-rich repeat	686..710	CDD:275381	8/25 (32%)
		leucine-rich repeat	711..735	CDD:275381	6/23 (26%)
		leucine-rich repeat	737..761	CDD:275381	8/52 (15%)
Fbxl20	XP_006534361.1	F-box-like	30..71	CDD:403981	17/40 (43%)
		leucine-rich repeat	67..94	CDD:275381	6/26 (23%)
		AMN1	95..291	CDD:187754	64/203 (32%)
		leucine-rich repeat	95..114	CDD:275381	4/18 (22%)
		leucine-rich repeat	121..146	CDD:275381	7/25 (28%)
		leucine-rich repeat	147..172	CDD:275381	10/24 (42%)
		leucine-rich repeat	173..198	CDD:275381	6/31 (19%)
		leucine-rich repeat	199..224	CDD:275381	8/24 (33%)
		AMN1	222..396	CDD:187754	59/174 (34%)
		leucine-rich repeat	225..250	CDD:275381	11/24 (46%)
		leucine-rich repeat	251..276	CDD:275381	10/24 (42%)
		leucine-rich repeat	277..302	CDD:275381	11/24 (46%)
		leucine-rich repeat	303..328	CDD:275381	5/24 (21%)
		leucine-rich repeat	329..357	CDD:275381	8/27 (30%)
		leucine-rich repeat	358..382	CDD:275381	7/24 (29%)
		leucine-rich repeat	383..408	CDD:275381	3/24 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940