DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and Fbxl2

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_848739.1	Gene:	Fbxl2 / 72179	MGIID:	1919429	Length:	423	Species:	Mus musculus

Alignment Length:	432	Identity:	121/432 - (28%)
Similarity:	205/432 - (47%)	Gaps:	83/432 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 GPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLA-----WRPI------------------ 439
            |.:..:||.|.::||||:||...||..|::.:.:..||     |:.:
Mouse     9 GLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRVDLFNFQTDVEGRVVENIS 73

  Fly   440 -----LWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGC-RISDKGLQLLTRR 498
                 ..:.:||||....||.:||...:.         |..:|.:.| :|| :|:|.....|:|.
Mouse    74 KRCGGFLRKLSLRGCIGVGDSSLKTFAQN---------CRNIEHLNL-NGCTKITDSTCYSLSRF 128

  Fly   499 CPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEPPRRLL-----LQY 558
            |.:|.||.|.:||.:||.:|......|.||::|:::.|.|::.       |....|:     |:.
Mouse   129 CSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQITK-------EGIEALVRGCRGLKA 186

  Fly   559 LDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFG 623
            |.|..|..::|..||.:..:|.:||.|.|:.|.::||.|:..:...|..|:.|.:|.|.|:||..
Mouse   187 LLLRGCTQLEDEALKHIQNHCHELVSLNLQSCSRITDDGVVQICRGCHRLQALCLSGCSNLTDAS 251

  Fly   624 LYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARSCPRLRA 688
            |..|......|:.|..|:|..::|||..::||.|::|..::...|..::|.::..|:..||:|:|
Mouse   252 LTALGLNCPRLQVLEAARCSHLTDAGFTLLARNCHELEKMDLEECVLITDSTLVQLSIHCPKLQA 316

  Fly   689 LDIGKCD-VSDAGLRALAES-C--PNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQDCP--- 746
            |.:..|: ::|.|:..|:.| |  ..|:.|.|.:|.::||..::.:. .||||::|.:.||.
Mouse   317 LSLSHCELITDEGILHLSSSTCGHERLRVLELDNCLLVTDASLEHLE-NCRGLERLELYDCQQVT 380

  Fly   747 -------------VSIEGYRAV-----------KKYCKRCII 764
                         |.:..|.|.           .:.|:.|:|
Mouse   381 RAGIKRMRAQLPHVKVHAYFAPVTPPPAVAGSGHRLCRCCVI 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	16/73 (22%)
		leucine-rich repeat	441..460	CDD:275381	8/18 (44%)
		AMN1	<451..595	CDD:187754	44/149 (30%)
		leucine-rich repeat	476..501	CDD:275381	9/25 (36%)
		leucine-rich repeat	502..521	CDD:275381	9/18 (50%)
		leucine-rich repeat	528..555	CDD:275381	5/26 (19%)
		leucine-rich repeat	556..581	CDD:275381	8/24 (33%)
		AMN1	577..746	CDD:187754	56/172 (33%)
		leucine-rich repeat	582..607	CDD:275381	9/24 (38%)
		leucine-rich repeat	608..633	CDD:275381	9/24 (38%)
		leucine-rich repeat	634..659	CDD:275381	10/24 (42%)
		leucine-rich repeat	660..685	CDD:275381	5/24 (21%)
		leucine-rich repeat	686..710	CDD:275381	9/27 (33%)
		leucine-rich repeat	711..735	CDD:275381	6/23 (26%)
		leucine-rich repeat	737..761	CDD:275381	8/50 (16%)
Fbxl2	NP_848739.1	F-box-like	15..57	CDD:289689	15/41 (37%)
		leucine-rich repeat	52..79	CDD:275381	1/26 (4%)
		LRR 1	61..87		2/25 (8%)
		AMN1	<76..223	CDD:187754	48/163 (29%)
		leucine-rich repeat	80..99	CDD:275381	8/18 (44%)
		Interaction with Calmodulin. /evidence=ECO:0000269\|PubMed:21343341	80..90		4/9 (44%)
		LRR 2	88..113		7/34 (21%)
		leucine-rich repeat	106..131	CDD:275381	9/25 (36%)
		LRR 3	114..139		10/24 (42%)
		leucine-rich repeat	132..157	CDD:275381	10/24 (42%)
		LRR 4	140..165		9/24 (38%)
		leucine-rich repeat	158..183	CDD:275381	6/31 (19%)
		LRR 5	166..191		7/31 (23%)
		AMN1	168..367	CDD:187754	61/206 (30%)
		leucine-rich repeat	184..209	CDD:275381	8/24 (33%)
		LRR 6	192..217		9/24 (38%)
		leucine-rich repeat	210..235	CDD:275381	9/24 (38%)
		LRR 7	218..243		7/24 (29%)
		leucine-rich repeat	236..261	CDD:275381	9/24 (38%)
		LRR 8	244..269		8/24 (33%)
		leucine-rich repeat	262..287	CDD:275381	10/24 (42%)
		LRR 9	270..295		8/24 (33%)
		leucine-rich repeat	288..313	CDD:275381	5/24 (21%)
		LRR 10	296..321		8/24 (33%)
		leucine-rich repeat	314..336	CDD:275381	7/21 (33%)
		LRR 11	322..350		9/27 (33%)
		leucine-rich repeat	343..362	CDD:275381	6/18 (33%)
		LRR 12	351..375		8/24 (33%)
		LRR 13	376..401		3/24 (13%)
		CAAX motif	420..423		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940