DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and FBXL17

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_005272105.1	Gene:	FBXL17 / 64839	HGNCID:	13615	Length:	712	Species:	Homo sapiens

Alignment Length:	778	Identity:	166/778 - (21%)
Similarity:	263/778 - (33%)	Gaps:	253/778 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PLSSSPLDPQAY------KMMSRKSPNPGLEVAEALASR---SSTPPSDQAGASSTAAAAAVLHM 91
            |||..|.| .||      :.::|:......|...|.|.|   ||...:..|.||:::.|:....:
Human    81 PLSPPPRD-GAYAAASSSQHLARRYAALAAEDCAAAARRFLLSSAAAAAAAAASASSPASCCKEL 144

  Fly    92 VQQKAATFELRGR-----HSRPTEQQTSYGAHSTASVGRHAKKSP-ELPAP----ASRNVAPVP- 145
            ....||.:|.:||     ...|..   ..|..:...:.|....|| |||.|    ..|..|.||
Human   145 GLAAAAAWEQQGRSLFLASLGPVR---FLGPPAAVQLFRGPTPSPAELPTPPEMVCKRKGAGVPA 206

  Fly   146 -----QPRNFLTLEHVLQFGTQRPSWMHGNSADTEDSSDNNAGGGGAGSGSGGAGGRRRAQGGRC 205
                 |||                                 .||||.|.|.||.||
Human   207 CTPCKQPR---------------------------------CGGGGCGGGGGGGGG--------- 229

  Fly   206 SVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRTLPLGAEASQFQNERYYLEDYSSGSGNERLP 270
                    .|..|.||                  :.|...:|                 |..:.|
Human   230 --------GGPAGGGA------------------SPPRPPDA-----------------GCCQAP 251

  Fly   271 ERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCNLGRFSPSLDQGYATLVSPSPT 335
            |:...|                                   ||                  |.|
Human   252 EQPPQP-----------------------------------LC------------------PPP- 262

  Fly   336 GHHSSGGAGNVTNSTTASGAGIMASSTPTTTPRRGASSNGLGGGAASAIGPPPWNRKGPFRCG-- 398
                        :|.|:.||       ||..          ||.|..|.|..|.:.:....||
Human   263 ------------SSPTSEGA-------PTEA----------GGDAVRAGGTAPLSAQQQHECGDA 298

  Fly   399 --------------------PLFDRLPDEAVVRIFSWLDSCELC-NVARVCRRFEHLAWRPILWK 442
                                |..::||...:::|||.|...|.| :.:.||:.:..|......||
Human   299 DCRESPENPCDCHREPPPETPDINQLPPSILLKIFSNLSLDERCLSASLVCKYWRDLCLDFQFWK 363

  Fly   443 VISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCR-ISDKGLQLLTRRCPELTHLQ 506
            .:.|.......|:.|:    ::..:|.|     :..:.::| || :||.|:.:|..:||.|....
Human   364 QLDLSSRQQVTDELLE----KIASRSQN-----IIEINISD-CRSMSDNGVCVLAFKCPGLLRYT 418

  Fly   507 LQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEPPRRLLLQYLDLTD-----CMA 566
            ...|..:::.:::...:.|..||.:.|....:::.       |..::|..:..:|.|     |..
Human   419 AYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTD-------EGLKQLGSKCRELKDIHFGQCYK 476

  Fly   567 IDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKL- 630
            |.|.|:.::.|.|.:|..:|::....|||..:|.....|..|:.:....| ::|..|:..|.||
Human   477 ISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGC-SVTSKGVIHLTKLR 540

  Fly   631 ---GAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIG 692
               ...||:::....|.|.:     |.:||..|..||......::|..:.|:|:....|:.|.:.
Human   541 NLSSLDLRHITELDNETVME-----IVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLV 600

  Fly   693 KCDVSDAGLRALAESCPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQDCPVSIEGYRAV 755
            .|.::|..|.|:......::.:.:..|..|||:|...||...:.|:.|.:..|......|:.|
Human   601 SCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVRVDYQVV 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	13/46 (28%)
		leucine-rich repeat	441..460	CDD:275381	5/18 (28%)
		AMN1	<451..595	CDD:187754	32/149 (21%)
		leucine-rich repeat	476..501	CDD:275381	8/25 (32%)
		leucine-rich repeat	502..521	CDD:275381	2/18 (11%)
		leucine-rich repeat	528..555	CDD:275381	4/26 (15%)
		leucine-rich repeat	556..581	CDD:275381	8/29 (28%)
		AMN1	577..746	CDD:187754	44/172 (26%)
		leucine-rich repeat	582..607	CDD:275381	7/24 (29%)
		leucine-rich repeat	608..633	CDD:275381	7/28 (25%)
		leucine-rich repeat	634..659	CDD:275381	7/24 (29%)
		leucine-rich repeat	660..685	CDD:275381	6/24 (25%)
		leucine-rich repeat	686..710	CDD:275381	6/23 (26%)
		leucine-rich repeat	711..735	CDD:275381	7/23 (30%)
		leucine-rich repeat	737..761	CDD:275381	5/19 (26%)
FBXL17	XP_005272105.1	F-box-like	321..368	CDD:289689	13/46 (28%)
		leucine-rich repeat	362..387	CDD:275381	6/28 (21%)
		leucine-rich repeat	388..413	CDD:275381	8/25 (32%)
		AMN1	411..573	CDD:187754	41/174 (24%)
		leucine-rich repeat	414..439	CDD:275381	3/24 (13%)
		leucine-rich repeat	440..465	CDD:275381	5/31 (16%)
		leucine-rich repeat	466..491	CDD:275381	8/24 (33%)
		leucine-rich repeat	492..517	CDD:275381	7/24 (29%)
		leucine-rich repeat	518..541	CDD:275381	7/23 (30%)
		leucine-rich repeat	542..567	CDD:275381	7/29 (24%)
		AMN1	547..>652	CDD:187754	28/109 (26%)
		leucine-rich repeat	568..593	CDD:275381	6/24 (25%)
		leucine-rich repeat	594..615	CDD:275381	6/20 (30%)
		leucine-rich repeat	619..641	CDD:275381	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810