DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and fbxl7

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001073511.1	Gene:	fbxl7 / 569430	ZFINID:	ZDB-GENE-061215-122	Length:	489	Species:	Danio rerio

Alignment Length:	508	Identity:	220/508 - (43%)
Similarity:	314/508 - (61%)	Gaps:	44/508 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 SPSETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCNLGRFSPSLDQGYATLVSPSPTGHHSSGGAG 344
            |.||..||       ||.|:.|.|.....|.........|...|....|:.:|||.
Zfish     9 SGSEGKGS-------SSISSDLSSSTDQTSTKAPKNAATSEDSDLSMRTVSTPSPA--------- 57

  Fly   345 NVTNSTTASGAGIMASSTPTTTPRRGASSNGLGGGAASAIGPPPWNRKGPFRC--------GPLF 401
             :.....:|.|.:..|||         ||:..|....:.:..||.:...|.||        |...
Zfish    58 -LILPPRSSSAVLNGSST---------SSSTFGTETIAMVHMPPTSLTHPQRCLRQPRDQQGAPV 112

  Fly   402 DRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCG 466
            |.|||.|.::||:.|.:.:||..||||||:.:|||.|.||:.|.|.|:.|:.|:.|:::.|:||
Zfish   113 DILPDHAFLQIFTHLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGDVLHVDRALRVLTRRLC- 176

  Fly   467 QSCNGACPEVERVMLADGC-RISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQH 530
            |.....|..||.||:: || |::|:||..:.:.||||..|::..|.:::|:|:.|.:::|.||:|
Zfish   177 QDTPNVCLTVETVMVS-GCRRLTDRGLYTVAQSCPELRRLEVAGCYNVSNEAVFEVVSRCPNLEH 240

  Fly   531 LDVTGCSQVSSIS----PNPHMEP--PRRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRR 589
            |||:|||:|:.||    .:..:.|  .:::.:::||:|||.|::|.||..:..:|.||.:|||||
Zfish   241 LDVSGCSKVTCISLTRDVSVKLSPLHGQQISIRFLDMTDCFALEDEGLHTIAAHCTQLTHLYLRR 305

  Fly   590 CIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIA 654
            |:::||.||:|:..:|..::|||||||..|:||||.|:|||...|||||:|.|.|::|.|::.:|
Zfish   306 CVRLTDEGLRFLVIYCPGVRELSVSDCRFISDFGLREIAKLEGRLRYLSIAHCSRITDVGVRYVA 370

  Fly   655 RRCYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIGKCD-VSDAGLRALAESCPNLKKLSLRS 718
            :.|.:||||||||||.::|..|..||:||.:|::||||||. ||||||..||.:..|||:|||:|
Zfish   371 KYCSRLRYLNARGCEGLTDHGIEHLAKSCLKLKSLDIGKCPLVSDAGLEQLALNSFNLKRLSLKS 435

  Fly   719 CDMITDRGVQCIAYYCRGLQQLNIQDCPVSIEGYRAVKKYCKRCIIEHTNPGF 771
            |:.||.||:|.:|..|..||.||:|||.||:|..|.||::|||||||||||.|
Zfish   436 CESITGRGLQVVAANCFDLQLLNVQDCDVSLEALRFVKRHCKRCIIEHTNPAF 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	23/45 (51%)
		leucine-rich repeat	441..460	CDD:275381	7/18 (39%)
		AMN1	<451..595	CDD:187754	59/150 (39%)
		leucine-rich repeat	476..501	CDD:275381	11/25 (44%)
		leucine-rich repeat	502..521	CDD:275381	5/18 (28%)
		leucine-rich repeat	528..555	CDD:275381	12/32 (38%)
		leucine-rich repeat	556..581	CDD:275381	10/24 (42%)
		AMN1	577..746	CDD:187754	95/169 (56%)
		leucine-rich repeat	582..607	CDD:275381	13/24 (54%)
		leucine-rich repeat	608..633	CDD:275381	16/24 (67%)
		leucine-rich repeat	634..659	CDD:275381	12/24 (50%)
		leucine-rich repeat	660..685	CDD:275381	16/24 (67%)
		leucine-rich repeat	686..710	CDD:275381	15/24 (63%)
		leucine-rich repeat	711..735	CDD:275381	13/23 (57%)
		leucine-rich repeat	737..761	CDD:275381	14/23 (61%)
fbxl7	NP_001073511.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76		22/92 (24%)
		F-box-like	112..158	CDD:289689	23/45 (51%)
		leucine-rich repeat	127..151	CDD:275381	13/23 (57%)
		leucine-rich repeat	152..185	CDD:275381	12/33 (36%)
		LRR 1	168..193		10/26 (38%)
		AMN1	<183..364	CDD:187754	82/181 (45%)
		leucine-rich repeat	186..211	CDD:275381	11/25 (44%)
		LRR 2	194..219		10/24 (42%)
		leucine-rich repeat	212..233	CDD:275381	6/20 (30%)
		LRR 3	220..245		11/24 (46%)
		leucine-rich repeat	238..271	CDD:275381	12/32 (38%)
		LRR 4	251..279		5/27 (19%)
		leucine-rich repeat	272..297	CDD:275381	10/24 (42%)
		LRR 5	280..305		11/24 (46%)
		AMN1	295..463	CDD:187754	95/167 (57%)
		leucine-rich repeat	298..323	CDD:275381	13/24 (54%)
		LRR 6	306..331		11/24 (46%)
		leucine-rich repeat	324..349	CDD:275381	16/24 (67%)
		LRR 7	332..357		15/24 (63%)
		leucine-rich repeat	350..375	CDD:275381	12/24 (50%)
		LRR 8	358..383		12/24 (50%)
		leucine-rich repeat	376..401	CDD:275381	16/24 (67%)
		LRR 9	384..409		12/24 (50%)
		leucine-rich repeat	402..427	CDD:275381	15/24 (63%)
		LRR 10	410..435		15/24 (63%)
		leucine-rich repeat	428..451	CDD:275381	13/22 (59%)
		LRR 11	436..461		12/24 (50%)
		leucine-rich repeat	454..478	CDD:275381	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I6965
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69121
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1950
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	1	1.000	-	-		FOG0006053
OrthoInspector	1	1.000	-	-		otm24985
orthoMCL	1	0.900	-	-		OOG6_107386
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	1	1.000	-	-		X4348
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.900