DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and FBXL12

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_016882401.1	Gene:	FBXL12 / 54850	HGNCID:	13611	Length:	343	Species:	Homo sapiens

Alignment Length:	350	Identity:	70/350 - (20%)
Similarity:	126/350 - (36%)	Gaps:	106/350 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 HLAWRP-ILWKVI---------SLR--GEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGC 485
            ||..|| ::|.::         |||  |...:|.:                 .|::...:
Human    68 HLQMRPKVMWHLLRRYMASRLHSLRMGGYLFSGSQ-----------------APQLSPAL----- 110

  Fly   486 RISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEP 550
                  |:.|.::||.|..|    |:.:.:.::|...:..|.|:.|::..| ::|....:...:|
Human   111 ------LRALGQKCPNLKRL----CLHVADLSMVPITSLPSTLRTLELHSC-EISMAWLHKQQDP 164

  Fly   551 PRRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSD 615
                  ..|.|.:|:.:|.                               ||:|
Human   165 ------TVLPLLECIVLDR-------------------------------VPAF----------- 181

  Fly   616 CLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLA 680
                .|..|..|.:. .|||.|.:....||::.||....:....|:.|...||...:|.::..::
Human   182 ----RDEHLQGLTRF-RALRSLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADSTLLAIS 241

  Fly   681 RSCPRLRALDIGKCDVSDAGLRALAESCPNLKKLSLRSCDMITDR--GVQCIAYYCRGLQQLNIQ 743
            |....:|.:.:....:|..|| |:.|..|.|:.|.|:. .::|..  ....|...|..:.:|.:.
Human   242 RHLRDVRKIRLTVRGLSAPGL-AVLEGMPALESLCLQG-PLVTPEMPSPTEILSSCLTMPKLRVL 304

  Fly   744 DCP-VSIEGYRAVKKYCK---RCII 764
            :.. :..||..|.|..||   .|::
Human   305 ELQGLGWEGQEAEKILCKGLPHCMV 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	6/23 (26%)
		leucine-rich repeat	441..460	CDD:275381	6/29 (21%)
		AMN1	<451..595	CDD:187754	20/143 (14%)
		leucine-rich repeat	476..501	CDD:275381	3/24 (13%)
		leucine-rich repeat	502..521	CDD:275381	4/18 (22%)
		leucine-rich repeat	528..555	CDD:275381	5/26 (19%)
		leucine-rich repeat	556..581	CDD:275381	4/24 (17%)
		AMN1	577..746	CDD:187754	34/170 (20%)
		leucine-rich repeat	582..607	CDD:275381	3/24 (13%)
		leucine-rich repeat	608..633	CDD:275381	3/24 (13%)
		leucine-rich repeat	634..659	CDD:275381	7/24 (29%)
		leucine-rich repeat	660..685	CDD:275381	6/24 (25%)
		leucine-rich repeat	686..710	CDD:275381	6/23 (26%)
		leucine-rich repeat	711..735	CDD:275381	5/25 (20%)
		leucine-rich repeat	737..761	CDD:275381	7/27 (26%)
FBXL12	XP_016882401.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810