DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxl7 and FBXL12

DIOPT Version :10

Sequence 1:NP_650512.1 Gene:Fbxl7 / 41935 FlyBaseID:FBgn0038385 Length:772 Species:Drosophila melanogaster
Sequence 2:XP_054177302.1 Gene:FBXL12 / 54850 HGNCID:13611 Length:343 Species:Homo sapiens


Alignment Length:181 Identity:31/181 - (17%)
Similarity:55/181 - (30%) Gaps:87/181 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   238 NGREWEESG-------------HFPRVTLCDFEVKVLGNVHRHTVQCVLMINMFNEKIFLFLW-- 287
            :|.:.:|:|             |.|.||       .||.|....:|   .::...||..:.||  
Human    60 SGCKGQEAGSCNPPALHLYLRSHLPSVT-------YLGKVSTTGMQ---FLSGCTEKPVIELWKK 114

  Fly   288 ---------------------FWY---------------FLLAGATLC--------SLFYWIYIS 308
                                 .|.               |.:|....|        ::|.|:|  
Human   115 HTLAREDVFPANALLEIRPFQVWLHHLDHKGEATVHMDTFQVARIAYCTADHNVSPNIFAWVY-- 177

  Fly   309 VVPSRQLNFVGKYL---------TGIEGYKMVDS--QSLRRFVFHFLRQDG 348
                |::|....|.         :.:|..|:..:  ::.:: .||.::.||
Human   178 ----REINDDLSYQMDCHAVQCESKLEAKKLAHAMMEAFKK-TFHSMKSDG 223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl7NP_650512.1 leucine-rich repeat 502..521 CDD:275381
leucine-rich repeat 528..555 CDD:275381
leucine-rich repeat 556..581 CDD:275381
AMN1 577..746 CDD:187754
leucine-rich repeat 582..607 CDD:275381
leucine-rich repeat 608..633 CDD:275381
leucine-rich repeat 634..659 CDD:275381
leucine-rich repeat 660..685 CDD:275381
leucine-rich repeat 686..710 CDD:275381
leucine-rich repeat 711..735 CDD:275381
leucine-rich repeat 737..761 CDD:275381
dermokine <279..>394 CDD:455732 20/127 (16%)
F-box_SF 401..444 CDD:459239
leucine-rich repeat 441..460 CDD:275381
leucine-rich repeat 476..501 CDD:275381
LRR <483..>640 CDD:443914
FBXL12XP_054177302.1 leucine-rich repeat 195..220 CDD:275381 4/25 (16%)
leucine-rich repeat 221..246 CDD:275381 2/3 (67%)
leucine-rich repeat 247..270 CDD:275381
leucine-rich repeat 301..336 CDD:275381
LRR <117..>308 CDD:443914 16/114 (14%)
leucine-rich repeat 121..142 CDD:275381 1/20 (5%)
leucine-rich repeat 170..194 CDD:275381 6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

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