DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and FBXL19

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001093254.2	Gene:	FBXL19 / 54620	HGNCID:	25300	Length:	694	Species:	Homo sapiens

Alignment Length:	664	Identity:	147/664 - (22%)
Similarity:	217/664 - (32%)	Gaps:	202/664 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 GRHSR-----PTEQQTSYGAHSTASVGRHAK--KSPELPAPASRNVAPV---PQPRNFLTLEHVL 157
            ||.|:     |..::...|... ||:|...|  :.|.||.|..|...|:   |.|.:       :
Human   152 GRTSKDSGEGPGRRRADNGEEG-ASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPED-------V 208

  Fly   158 QFGTQRPSWMHGNSADTEDSSDNNAGGGGAGSGSGGAGGRRRAQGGR-----------CSVPTVL 211
            ....:|.....||...|.                     |::.:|||           |    :|
Human   209 PGPPKRKEREAGNEPPTP---------------------RKKVKGGRERHLKKVGGDAC----LL 248

  Fly   212 SSNGSGGNGAQYLLDKKMESLYLGNALRTLPLGAEASQFQNERYYLEDYSSGSG---------NE 267
            ..:..||.|   ||..::  |....|..:...|.....::..:..|   :|..|         .|
Human   249 RGSDPGGPG---LLPPRV--LNPSQAFSSCHPGLPPENWEKPKPPL---ASAEGPAVPSPSPQRE 305

  Fly   268 RLP---------ERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQSLSD----GLCNLGRFS 319
            :|.         ||:  |.|||.|..|.||.            .|.|.|||:    |....||
Human   306 KLERFKRMCQLLERV--PDTSSSSSDSDSDS------------DSSGTSLSEDEAPGEARNGR-- 354

  Fly   320 PSLDQGYATLVSPSPTGHHSSGGAGNVTNS------TTASGAGIMASSTPTTTPRRGASSNGLGG 378
                             ..:.|.:|...|.      ...||..:::.......|.|.....
Human   355 -----------------RPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLE---- 398

  Fly   379 GAASAIGPPPWNRKG---PFRCG---PLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWR 437
              ...:.|||.:.:.   |...|   |    ||..|.:|:|..|...|||...||||.:....:.
Human   399 --RHVVRPPPRSPEPDTLPLAAGSDHP----LPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYD 457

  Fly   438 PILWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCRISDKGLQLLTRRCPEL 502
            ..||..:.|...            :.|.....:|......|.:......:|.|.|..|..|...|
Human   458 KRLWPRMDLSRR------------KSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGL 510

  Fly   503 THLQLQTCVDITNQALVEALTKCSNLQHL----DVTGCSQVSSISPNPHMEPPR----------- 552
            ..|.|..|..::..||..|......|..|    ||........:.|.|..:|.:
Human   511 QELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVA 575

  Fly   553 RLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCL 617
            .|.|..|:|||.      .|::::::.|||..|.|..|..|.|..:..:.:....|:|
Human   576 ELRLAGLELTDA------SLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRE------- 627

  Fly   618 NITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARS 682
                           .|.:|::|.|.|::|..|.:. |||.:||.|:.|.|..:|.::...||.:
Human   628 ---------------TLVHLNLAGCHRLTDHCLPLF-RRCPRLRRLDLRSCRQLSPEACARLAAA 676

  Fly   683 -------CPRLRAL 689
                   ||..:.|
Human   677 GPPGPFRCPEEKLL 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	15/45 (33%)
		leucine-rich repeat	441..460	CDD:275381	2/18 (11%)
		AMN1	<451..595	CDD:187754	36/158 (23%)
		leucine-rich repeat	476..501	CDD:275381	6/24 (25%)
		leucine-rich repeat	502..521	CDD:275381	6/18 (33%)
		leucine-rich repeat	528..555	CDD:275381	7/41 (17%)
		leucine-rich repeat	556..581	CDD:275381	6/24 (25%)
		AMN1	577..746	CDD:187754	31/120 (26%)
		leucine-rich repeat	582..607	CDD:275381	6/24 (25%)
		leucine-rich repeat	608..633	CDD:275381	2/24 (8%)
		leucine-rich repeat	634..659	CDD:275381	10/24 (42%)
		leucine-rich repeat	660..685	CDD:275381	9/31 (29%)
		leucine-rich repeat	686..710	CDD:275381	1/4 (25%)
		leucine-rich repeat	711..735	CDD:275381
		leucine-rich repeat	737..761	CDD:275381
FBXL19	NP_001093254.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		zf-CXXC	<50..77	CDD:251032
		PHD_FXL19	87..148	CDD:277115
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..420		69/347 (20%)
		F-box-like	424..465	CDD:315592	15/40 (38%)
		leucine-rich repeat	461..485	CDD:275381	4/35 (11%)
		AMN1	466..665	CDD:332986	55/239 (23%)
		leucine-rich repeat	486..508	CDD:275381	6/21 (29%)
		LRR 1	492..517		8/24 (33%)
		leucine-rich repeat	510..533	CDD:275381	7/22 (32%)
		LRR 2	518..541		6/22 (27%)
		leucine-rich repeat	534..573	CDD:275381	7/38 (18%)
		leucine-rich repeat	574..598	CDD:275381	7/29 (24%)
		LRR 3	581..606		10/30 (33%)
		leucine-rich repeat	599..623	CDD:275381	6/23 (26%)
		LRR 4	607..636		7/50 (14%)
		leucine-rich repeat	629..653	CDD:275381	10/24 (42%)
		LRR 5	637..661		10/24 (42%)
		leucine-rich repeat	654..686	CDD:275381	9/31 (29%)
		LRR 6	662..694		7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840