DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and Fbxl16

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_038942467.1	Gene:	Fbxl16 / 494223	RGDID:	1309127	Length:	488	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	126/534 - (23%)
Similarity:	206/534 - (38%)	Gaps:	138/534 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 SPSLDQGYATLVSPSPT-----------GHHSSGGAGNVTNSTTASGAGIMASSTPTTTP----R 368
            ||.:|.      .|.|:           |..:..||.::|..|.|:.........|.|.|    .
  Rat     3 SPGIDG------DPKPSCLPRNGLVKLPGQPNGLGAASITKGTPAAKNRPCQPPPPPTLPPPSLA 61

  Fly   369 RGASSNGLGGG-----AASAIGPPPWNRKGPFRCGPLFDRLP---DEAVVR-IFSWLDSCELCNV 424
            ...|...|.||     :..|.||.|         ||..:|.|   ||.::. :|.:..:||.|.:
  Rat    62 TPLSRVALAGGPCPPASGPASGPVP---------GPPVERPPLATDEKILNGLFWYFSACEKCIL 117

  Fly   425 ARVCRRFEHLAWRPILWKVIS--LRGEHL-----NGDKTLKMI-------FRQLC--GQSCNGAC 473
            |:||:.:..:.::|..|..::  |..:.|     .|:|....:       |...|  |.|....|
  Rat   118 AQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNLQGFAARGFEGFCLVGVSDLDIC 182

  Fly   474 PEVERVMLA-DGCR--------ISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQ 529
            ..::...|: .|.:        |:|.||:::..:...:..|:|..|.|.|...|..:|:  :.:.
  Rat   183 EFIDNYSLSKKGVKAMSLKRSTITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWSSLS--ARIT 245

  Fly   530 HLDVTGC--------SQVSSISPNPHMEPPRRLLLQYLDLTD---------------------CM 565
            .|.|:.|        :.:|.:.||     ...|.||...:||                     |.
  Rat   246 SLSVSDCINVADDAIAAISQLLPN-----LAELSLQAYHVTDTALAYFTARQGHSTHTLRLLSCW 305

  Fly   566 AIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKL 630
            .|.:.|:..||.:.|.|..|.|..|.:|||.|::.|......|:.|.:|.|..|||..|..:|..
  Rat   306 EITNHGVVNVVHSLPNLTSLSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACD 370

  Fly   631 GAALRYLSVAKCE---------RVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARSCPRL 686
            ...|..|.:.:|.         |::|.||..::... .||.|..|.|
  Rat   371 LHRLEELVLDRCTHPYTPGWCVRITDTGLSYLSTMS-SLRSLYLRWC------------------ 416

  Fly   687 RALDIGKCDVSDAGLRALAESCPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQDCP-VSIE 750
                   |.|.|.||:.|. :..:|:.|||..|.::|..|:..:. ..:.|::|.:.:|| .:.|
  Rat   417 -------CQVQDFGLKHLL-AMRSLRLLSLAGCPLLTTTGLSGLV-QLQELEELELTNCPGATPE 472

  Fly   751 GYRAVKKYCKRCII 764
            .::...::..||::
  Rat   473 LFKYFSQHLPRCLV 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	13/51 (25%)
		leucine-rich repeat	441..460	CDD:275381	5/25 (20%)
		AMN1	<451..595	CDD:187754	43/195 (22%)
		leucine-rich repeat	476..501	CDD:275381	6/33 (18%)
		leucine-rich repeat	502..521	CDD:275381	6/18 (33%)
		leucine-rich repeat	528..555	CDD:275381	6/34 (18%)
		leucine-rich repeat	556..581	CDD:275381	9/45 (20%)
		AMN1	577..746	CDD:187754	46/177 (26%)
		leucine-rich repeat	582..607	CDD:275381	9/24 (38%)
		leucine-rich repeat	608..633	CDD:275381	9/24 (38%)
		leucine-rich repeat	634..659	CDD:275381	7/33 (21%)
		leucine-rich repeat	660..685	CDD:275381	5/24 (21%)
		leucine-rich repeat	686..710	CDD:275381	6/23 (26%)
		leucine-rich repeat	711..735	CDD:275381	7/23 (30%)
		leucine-rich repeat	737..761	CDD:275381	5/24 (21%)
Fbxl16	XP_038942467.1	leucine-rich repeat	195..219	CDD:275381	4/23 (17%)
		AMN1	201..422	CDD:187754	60/253 (24%)
		leucine-rich repeat	220..243	CDD:275381	7/24 (29%)
		leucine-rich repeat	244..269	CDD:275381	4/24 (17%)
		leucine-rich repeat	270..321	CDD:275381	10/50 (20%)
		leucine-rich repeat	322..347	CDD:275381	9/24 (38%)
		leucine-rich repeat	348..373	CDD:275381	9/24 (38%)
		leucine-rich repeat	374..407	CDD:275381	7/33 (21%)
		leucine-rich repeat	408..427	CDD:275381	10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810