DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and Kdm2

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001262400.1	Gene:	Kdm2 / 41090	FlyBaseID:	FBgn0037659	Length:	1345	Species:	Drosophila melanogaster

Alignment Length:	707	Identity:	159/707 - (22%)
Similarity:	257/707 - (36%)	Gaps:	185/707 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YHHPHPLSSSPLDPQAYKMMSRKSPNPGLEVAEALASRSSTPPSDQAGASSTAAAAAVLHMVQQ- 94
            |.|......:|:.||..::.|...|:..:|.  ::....:.|....:....|..||....:|.:
  Fly   729 YCHLDGWRQTPVSPQTKQLASADGPSALMEC--SVCYEIAHPDCALSQLDGTEDAADAKGIVNED 791

  Fly    95 ------------KAATFELRGRHSRPTEQQTSYG----AHSTASVGRHAKKSPELPAPASRNVAP 143
                        ....::.:.||.|..::.:...    :|.......||..:..||       .|
  Fly   792 LPNSWECPSCCRSGKNYDYKPRHFRARQKSSEVRRVSVSHGQGGAEGHADGNTLLP-------PP 849

  Fly   144 VPQPRNFL-TLEHVLQFGT---QRPSWMHG--------------NSADTEDS--SDNNAGGGGAG 188
            |.|..:|: |.|..::.||   ....|.||              ||.||...  |.|..|
  Fly   850 VGQYNDFVFTSESEMESGTVSGHMTHWKHGMKRHHQLEVKTERNNSCDTPSPGISPNAIG----- 909

  Fly   189 SGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRTLPLGAEASQFQNE 253
             |....|.||::..|     |.:||:....|.|                    |.|:.|
  Fly   910 -GDSKVGKRRKSDDG-----TSVSSSMHESNDA--------------------PCGSSA------ 942

  Fly   254 RYYLEDYSSGSGNERLPERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCNLGRF 318
                 :.:.|:||..:          |.::.|||.....:|..||.......|.|:.....|.:
  Fly   943 -----EGAGGAGNANV----------STNQWSGSGGGGGSRKKNSIRSQLAQQMLNSSTRVLKK- 991

  Fly   319 SPSLDQGYATLVSP-SPTGHHSSGGAG-------NVTNSTTASGAGIMASSTPTTTPRRGASSNG 375
             |..      :|.| |.||..||.|.|       .::|.:..||    |:|.......||.::.|
  Fly   992 -PQY------VVRPASGTGSSSSSGNGGSASATNGISNGSNQSG----ANSCGAGNGERGTNNGG 1045

  Fly   376 LGGGAASAIGPPPWNRKGPFRCGPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPIL 440
            |.|  ::.:|...::........|...::       ||.:|....|.....||:.:.:.|..|.|
  Fly  1046 LSG--SNGLGNQHYSSSQNLALDPTVLKI-------IFRYLPQDTLVTCCSVCKVWSNAAVDPDL 1101

  Fly   441 WKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCRISDKGLQLLTRRCPELTHL 505
            ||.::. .||......|..|.|:           :.|.::| |..:|:.:.|..|..|.|.|.:|
  Fly  1102 WKKMNC-SEHKMSASLLTAIVRR-----------QPEHLIL-DWTQIAKRQLAWLVARLPALKNL 1153

  Fly   506 QLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEPP--------------RRLLL 556
            .||.|......||...|  |..||.||::....::..:....:.||              |.|.:
  Fly  1154 SLQNCPIQAVLALHTCL--CPPLQTLDLSFVRGLNDAAIRDILSPPKDSRPGLSDSKTRLRDLKV 1216

  Fly   557 QYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVS---LKELSVSDCLN 618
            ..|..||   |.|:.::.:.::.|.|.:|.|..|.::||||:..:.:...:   |.||::|.|..
  Fly  1217 MKLAGTD---ISDVAVRYITQSLPYLRHLDLSSCQRITDAGVAQIGTSTTATARLTELNLSACRL 1278

  Fly   619 ITDFGLYELAK----------------LGAALRYLSVAK---CERVSDAGLKVIARR 656
            :::..|..|||                ..:.:|:.|.:|   |.|    .:|::.||
  Fly  1279 VSENALEHLAKCEGLIWLDLRHVPQVSTQSVIRFASNSKHDLCVR----DIKLVERR 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	11/45 (24%)
		leucine-rich repeat	441..460	CDD:275381	5/18 (28%)
		AMN1	<451..595	CDD:187754	38/157 (24%)
		leucine-rich repeat	476..501	CDD:275381	7/24 (29%)
		leucine-rich repeat	502..521	CDD:275381	7/18 (39%)
		leucine-rich repeat	528..555	CDD:275381	7/40 (18%)
		leucine-rich repeat	556..581	CDD:275381	5/24 (21%)
		AMN1	577..746	CDD:187754	26/102 (25%)
		leucine-rich repeat	582..607	CDD:275381	8/24 (33%)
		leucine-rich repeat	608..633	CDD:275381	9/40 (23%)
		leucine-rich repeat	634..659	CDD:275381	8/26 (31%)
		leucine-rich repeat	660..685	CDD:275381
		leucine-rich repeat	686..710	CDD:275381
		leucine-rich repeat	711..735	CDD:275381
		leucine-rich repeat	737..761	CDD:275381
Kdm2	NP_001262400.1	cupin_like	231..331	CDD:304367
		PRTases_typeI	<394..>467	CDD:294217
		zf-CXXC	670..716	CDD:251032
		PHD_4	721..801	CDD:293471	13/73 (18%)
		F-box-like	<1073..1108	CDD:289689	11/35 (31%)
		leucine-rich repeat	1102..1125	CDD:275381	7/34 (21%)
		leucine-rich repeat	1126..1149	CDD:275381	7/23 (30%)
		leucine-rich repeat	1150..1173	CDD:275381	9/24 (38%)
		AMN1	1166..>1320	CDD:187754	37/158 (23%)
		leucine-rich repeat	1174..1213	CDD:275381	6/38 (16%)
		leucine-rich repeat	1214..1238	CDD:275381	6/26 (23%)
		leucine-rich repeat	1239..1267	CDD:275381	8/27 (30%)
		leucine-rich repeat	1268..1292	CDD:275381	9/23 (39%)
		leucine-rich repeat	1293..1317	CDD:275381	2/23 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810