DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and Skp2

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	158/731 - (21%)
Similarity:	249/731 - (34%)	Gaps:	257/731 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NRRSSDLE--CPLASLGRNSNAVRDHY-------------HHPHPLSSSPLDPQAYKMMSRKSPN 56
            :|.|.::|  ||:.   |..:..::|.             |:.||.|.|.|..:|.:.|
  Fly     6 HRGSENMENLCPVT---RKRSTNKNHVSVVGALVSTTKSSHYEHPSSPSALTFEALEEM------ 61

  Fly    57 PGLEVAEALASRSSTPPSDQAGASSTAAAAAVLHMVQQKAATFELRGRHSRPTEQQTSYGAHSTA 121
             |:.:.:          |:::.:|:.:|.|..:      :||.:.....:.|           .|
  Fly    62 -GIGMLD----------SEESSSSALSAIALAV------SATSDDNSNETTP-----------CA 98

  Fly   122 SVGRHAKKSPELPAPASRNVAPVPQPRNFLTLEHVLQFGTQRPSWMHGNSAD-TEDSSDNNAGGG 185
            ||.|.|                           |.||. |||.|.  |::.| |.||.
  Fly    99 SVSRMA---------------------------HQLQH-TQRLSL--GSTGDITLDSP------- 126

  Fly   186 GAGSGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRTLPLGAEASQF 250
                                :|...||.:.......|.|...|..|           ||:|
  Fly   127 --------------------AVEDSLSMSRQSAEKLQILAQAKRSS-----------LGSE---- 156

  Fly   251 QNERYYLEDYSSGSGNERLP-ERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCN 314
                        ||||...| :||.:|               |...:.:|.:        ||..:
  Fly   157 ------------GSGNSNSPSKRLRNP---------------LAAVTCNNQI--------DGTAS 186

  Fly   315 LGRFSPSLDQGYATLVSPSPTGHHSSGGAGNVTNSTTASGAGIMASST--PTTTPRRGASSNGLG 377
            | .|.||..:......:..|          :.||.||.    |:|:.:  ...||...|..|
  Fly   187 L-NFQPSTSRLAQVRQAKKP----------STTNITTR----IVAADSFFVFRTPAMSAHIN--- 233

  Fly   378 GGAASAIGPPPWNRKGPFRCGPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWK 442
                |.|.              .|:||.||.::.||.||....|..:|.|||||...:....||.
  Fly   234 ----SGIN--------------YFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWT 280

  Fly   443 VISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVER-----VMLADG------------------ 484
            .:.|      |.:|::           .||..::.|     :.||..
  Fly   281 RLDL------GLRTIR-----------PGALEQIVRRGVLVIRLAQTSIQEPAFAPYTEVFRTRL 328

  Fly   485 -------CRISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSI 542
                   ..|:...|..|...|.:|..:.|:. :::.:....| :.|...|:.:::|..|.::|.
  Fly   329 QYLDLSMASITRSSLLTLLSHCRQLKKISLEN-IELDDDICAE-IAKNEALEAVNLTMASGLTSN 391

  Fly   543 SPNPHMEPPRRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVT-DAGLKFVPSFCV 606
            |....||....|....:..||..|  |....:|....|.|:.|.:..|.:|. |:.:..:...|.
  Fly   392 SVRLMMESLTSLSSLNISWTDLSA--DAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCP 454

  Fly   607 SLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCY-KLRYLNARGCEA 670
            .|.||.:|||.::|...:..:.|. ..|.||||::|..:  ...|.|..:.. .|.||:..|  .
  Fly   455 QLLELDLSDCNSLTPTVITAIMKF-KMLEYLSVSRCYLI--PATKFIELKSMPSLTYLDIFG--M 514

  Fly   671 VSDDSITVLARSCPRL 686
            :||.::.||.:..|::
  Fly   515 LSDTAMEVLEKQLPKM 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	18/45 (40%)
		leucine-rich repeat	441..460	CDD:275381	4/18 (22%)
		AMN1	<451..595	CDD:187754	33/174 (19%)
		leucine-rich repeat	476..501	CDD:275381	7/54 (13%)
		leucine-rich repeat	502..521	CDD:275381	2/18 (11%)
		leucine-rich repeat	528..555	CDD:275381	7/26 (27%)
		leucine-rich repeat	556..581	CDD:275381	5/24 (21%)
		AMN1	577..746	CDD:187754	32/112 (29%)
		leucine-rich repeat	582..607	CDD:275381	6/25 (24%)
		leucine-rich repeat	608..633	CDD:275381	8/24 (33%)
		leucine-rich repeat	634..659	CDD:275381	8/25 (32%)
		leucine-rich repeat	660..685	CDD:275381	8/24 (33%)
		leucine-rich repeat	686..710	CDD:275381	0/1 (0%)
		leucine-rich repeat	711..735	CDD:275381
		leucine-rich repeat	737..761	CDD:275381
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	18/44 (41%)
		leucine-rich repeat	302..327	CDD:275381	2/24 (8%)
		AMN1	309..480	CDD:187754	36/175 (21%)
		leucine-rich repeat	328..352	CDD:275381	4/23 (17%)
		leucine-rich repeat	353..376	CDD:275381	4/24 (17%)
		leucine-rich repeat	377..402	CDD:275381	7/24 (29%)
		leucine-rich repeat	403..428	CDD:275381	6/26 (23%)
		leucine-rich repeat	429..455	CDD:275381	6/25 (24%)
		leucine-rich repeat	456..480	CDD:275381	8/24 (33%)
		leucine-rich repeat	481..500	CDD:275381	8/20 (40%)
		leucine-rich repeat	506..529	CDD:275381	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457927
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840