DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and CG32085

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster

Alignment Length:	710	Identity:	163/710 - (22%)
Similarity:	247/710 - (34%)	Gaps:	201/710 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 SDNNAGGGGAGSGSGGAGG--RRRAQGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRT 240
            |..::|.||||..:..||.  ...|..|:.||...:::...||..:.            .|:
  Fly    33 SSTSSGAGGAGDAASPAGATPTPAAPSGKTSVMERVTNALCGGGNSN------------SNS--- 82

  Fly   241 LPLGAEASQFQNERYYLEDYSSGSGNERLPERLHHP-RTSSP-----------SETSGSDRYLLN 293
               |:.:|............:|.:.|...|:....| |.|||           |:...|..:||.
  Fly    83 ---GSNSSNSNTSSASATAATSPASNANPPQTPDKPSRGSSPSPGGITMPGGQSQVQNSTHHLLQ 144

  Fly   294 -----------RSSNSNHLHSKGQSLSDGLCNLGRFSPSLDQGYATLVSPSPTGHHSSGGAGNVT 347
                       :.|...||..:..:|             ::..:..:|.|:|......|.....|
  Fly   145 QQQQQQQHMQLQQSQQQHLQLQASTL-------------INSNHHVMVGPAPPTGMPLGAPPTPT 196

  Fly   348 -------NSTTASGAGIMASSTPTTTPRRGASSNGLGGGAASAIGPP--------------PWNR 391
                   .:.|..|.|:...|...:|....|:..    .||||.|.|              |:..
  Fly   197 VKSIAKQMNITIPGGGVNPGSPTFSTMGMVAAQK----AAASAGGTPLQLRKQLPNPHLHHPYGS 257

  Fly   392 KGPFRCGPLFDR---------------LPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWR-PIL 440
            .|.....||..:               |.|..:.|.|.:....|...:|:||.::....:| |..
  Fly   258 MGINAASPLIMQHQLHPPPIHSIEQLMLDDRFLSRFFQYFSPYERRILAQVCIKWRDTLYRSPRY 322

  Fly   441 WKVI----------------------SL--RGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVML 481
            |..:                      ||  ||.|..|          |.|.|...|...|....|
  Fly   323 WSGLLPTLQCRELRQMPGCDRGKLYNSLIRRGFHALG----------LVGASDEDALDVVHSFPL 377

  Fly   482 AD--------GC-RISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCS 537
            |.        .| .|||:||:.|......|..|:|..|.::|...|...||
  Fly   378 ASKHVHSLSLRCSSISDRGLETLLDHLQSLFELELAGCNEVTEAGLWACLT-------------- 428

  Fly   538 QVSSISPNPHMEPPRRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGL-KFV 601
                         ||   :..|.|.||:.|.|..:..|.:..|.| |.:..:...||||.| .|.
  Fly   429 -------------PR---IVSLSLADCINIADEAVGAVAQLLPSL-YEFSLQAYHVTDAALGYFS 476

  Fly   602 PSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNAR 666
            |....||..|.:..|..:|:.|:..:......|..||::.|.:::|.|:::||....|||.|:..
  Fly   477 PKQSHSLSILRLQSCWELTNHGIVNIVHSLPHLTVLSLSGCSKLTDDGVELIAENLQKLRALDLS 541

  Fly   667 GCEAVSDDSITVLARSCPRLRALDIGKC--------------------------DVSDAGLRALA 705
            .|..::|.|:..:|....:|..|.:.:|                          .|.|.||:.|.
  Fly   542 WCPRITDASLEYIACDLNQLEELTLDRCVHITDIGVGYISTMLSLTALFLRWCSQVRDFGLQHLC 606

  Fly   706 ESCPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQDCP-VSIEGYRAVKKYCKRCII 764
             |..||:.|||..|.::|..|:..: ...|.||:|.:.:|| .|.|.:..:|::..||:|
  Fly   607 -SMRNLQVLSLAGCPLLTSSGLSSL-IQLRHLQELELTNCPGASHELFDYLKEHLPRCLI 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	13/85 (15%)
		leucine-rich repeat	441..460	CDD:275381	7/42 (17%)
		AMN1	<451..595	CDD:187754	36/152 (24%)
		leucine-rich repeat	476..501	CDD:275381	10/33 (30%)
		leucine-rich repeat	502..521	CDD:275381	6/18 (33%)
		leucine-rich repeat	528..555	CDD:275381	2/26 (8%)
		leucine-rich repeat	556..581	CDD:275381	7/24 (29%)
		AMN1	577..746	CDD:187754	53/195 (27%)
		leucine-rich repeat	582..607	CDD:275381	9/25 (36%)
		leucine-rich repeat	608..633	CDD:275381	5/24 (21%)
		leucine-rich repeat	634..659	CDD:275381	8/24 (33%)
		leucine-rich repeat	660..685	CDD:275381	7/24 (29%)
		leucine-rich repeat	686..710	CDD:275381	9/49 (18%)
		leucine-rich repeat	711..735	CDD:275381	7/23 (30%)
		leucine-rich repeat	737..761	CDD:275381	8/24 (33%)
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	7/23 (30%)
		AMN1	383..600	CDD:187754	60/247 (24%)
		leucine-rich repeat	431..456	CDD:275381	7/24 (29%)
		leucine-rich repeat	457..482	CDD:275381	9/25 (36%)
		leucine-rich repeat	483..508	CDD:275381	5/24 (21%)
		leucine-rich repeat	509..534	CDD:275381	8/24 (33%)
		leucine-rich repeat	535..560	CDD:275381	7/24 (29%)
		leucine-rich repeat	561..585	CDD:275381	3/23 (13%)
		leucine-rich repeat	586..610	CDD:275381	6/24 (25%)
		leucine-rich repeat	636..661	CDD:275381	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457920
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47209
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.740