DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and Ppa

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	661	Identity:	149/661 - (22%)
Similarity:	239/661 - (36%)	Gaps:	193/661 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 NNAGGGGAGSGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGA-QYLLDKKMESLYLGNALRTLPL 243
            ||......||||.||     |..|..::      .|:|..|| .:.:|:..:...|....||
  Fly    19 NNLNSHCGGSGSNGA-----ATSGGAAI------GGAGAGGAPSWAMDELYQQTELPGLTRT--- 69

  Fly   244 GAEASQFQNERYYLEDYSSGSGNERLPERLHHPRTSSPSETSGSDRYLLN----------RSSNS 298
            ||..:.....|:             .|..|||.......:|.....||.:          .::::
  Fly    70 GATTTHHHLLRF-------------TPYALHHRPPHHQLQTLPPALYLQHAAAAAAAAAAAAAHA 121

  Fly   299 NHLHSKGQSLSDGLCNLGRFSPSLDQGYATLVSPSPTGHHSSGGAGNVTNSTTASGAGIMASSTP 363
            .|.|.                                 ||..
  Fly   122 QHHHH---------------------------------HHHH----------------------- 130

  Fly   364 TTTPRRGASSNGLGGGAASAIGPPPWNRKGPFRCGPLFDRLPDEAVVRIFSWLDSCELCNVARVC 428
              .|.|.||..          .|||..       |.....|..|.:.:||..|...:|...|:||
  Fly   131 --LPHRPASPE----------SPPPVE-------GTHISNLFPELLEQIFEHLPVRDLGRAAQVC 176

  Fly   429 RRFEHLAWRPILWK----------------------------VISLRGE--------------HL 451
            ..:...|:...:||                            ::|||..              :|
  Fly   177 TAWRDAAYAKSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNL 241

  Fly   452 NG-----DKTLKMIFRQLCGQSCNGACPEVERVMLADGCRISDKGLQLLTRRCPELTHLQLQTCV 511
            :|     |..|        |.:.:...|.::.:.|:...:|:|..|..:.:....|..|:|..|.
  Fly   242 SGCFNVADMNL--------GHAFSVDLPNLKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCC 298

  Fly   512 DITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEPPRR------LLLQYLDLTDCMAIDDM 570
            :|||..|:........|:||::..|..:|..... |:....|      |.|:||.|.||..:.|.
  Fly   299 NITNTGLLLIAWGLKKLKHLNLRSCWHISDQGIG-HLAGFSRETAEGNLQLEYLGLQDCQRLSDE 362

  Fly   571 GLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALR 635
            .|..:.:....|..:.|..|:.|||:|||.:... ..|::|::..|.||:|.|:..|.:.|:.:.
  Fly   363 ALGHIAQGLTSLKSINLSFCVSVTDSGLKHLARM-PKLEQLNLRSCDNISDIGMAYLTEGGSGIN 426

  Fly   636 YLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIGKCD-VSDA 699
            .|.|:.|:::||..|..||:..|:||.|:...|: ::|..:..:|::...|..|:||:|. ::|.
  Fly   427 SLDVSFCDKISDQALTHIAQGLYRLRSLSLNQCQ-ITDHGMLKIAKALHELENLNIGQCSRITDK 490

  Fly   700 GLRALAESCPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLN-----IQDCPVSIEGYRAVKKYC 759
            ||:.|||...|||.:.|..|..::.:|:..|....: ||:||     ::.|         |...|
  Fly   491 GLQTLAEDLTNLKTIDLYGCTQLSSKGIDIIMKLPK-LQKLNLGLWLVRXC---------VHHDC 545

  Fly   760 KRCIIEHTNPG 770
            ..|..:....|
  Fly   546 NACAAKEAARG 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	13/73 (18%)
		leucine-rich repeat	441..460	CDD:275381	9/65 (14%)
		AMN1	<451..595	CDD:187754	38/154 (25%)
		leucine-rich repeat	476..501	CDD:275381	4/24 (17%)
		leucine-rich repeat	502..521	CDD:275381	8/18 (44%)
		leucine-rich repeat	528..555	CDD:275381	7/32 (22%)
		leucine-rich repeat	556..581	CDD:275381	8/24 (33%)
		AMN1	577..746	CDD:187754	55/174 (32%)
		leucine-rich repeat	582..607	CDD:275381	9/24 (38%)
		leucine-rich repeat	608..633	CDD:275381	9/24 (38%)
		leucine-rich repeat	634..659	CDD:275381	8/24 (33%)
		leucine-rich repeat	660..685	CDD:275381	6/24 (25%)
		leucine-rich repeat	686..710	CDD:275381	11/24 (46%)
		leucine-rich repeat	711..735	CDD:275381	6/23 (26%)
		leucine-rich repeat	737..761	CDD:275381	7/28 (25%)
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	10/40 (25%)
		AMN1	<226..>334	CDD:187754	23/116 (20%)
		leucine-rich repeat	236..256	CDD:275381	5/27 (19%)
		leucine-rich repeat	263..288	CDD:275381	4/24 (17%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	7/32 (22%)
		AMN1	347..524	CDD:187754	59/178 (33%)
		leucine-rich repeat	348..373	CDD:275381	8/24 (33%)
		leucine-rich repeat	374..398	CDD:275381	9/24 (38%)
		leucine-rich repeat	399..424	CDD:275381	9/24 (38%)
		leucine-rich repeat	425..450	CDD:275381	8/24 (33%)
		leucine-rich repeat	451..475	CDD:275381	6/24 (25%)
		leucine-rich repeat	476..501	CDD:275381	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457917
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46756
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.740