DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and Fbxl22

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001102239.1	Gene:	Fbxl22 / 363083	RGDID:	1311830	Length:	236	Species:	Rattus norvegicus

Alignment Length:	294	Identity:	66/294 - (22%)
Similarity:	108/294 - (36%)	Gaps:	92/294 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 RLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVI------SLRGEHLNGDKTLKMIF 461
            :|..|.::|:||:||.....:::|.|.:...:...|.||.::      .|:.::......|:.:
  Rat     5 QLNRECLLRLFSFLDKDSRKSLSRTCSQLRDVFEDPTLWSLLHFHSLTELKKDNFRLSPALRSL- 68

  Fly   462 RQLCGQSCNGACPEVERVMLADGCRISDKGLQLLTRR--CPELTHLQLQTCVDITNQALVEALTK 524
             .:|..|        .||.:   |.|.| .|:...:|  |.:..:|        .|..|::...:
  Rat    69 -SICWHS--------SRVQV---CSIED-WLKSAFQRSICSQHENL--------VNDFLLQVCNR 112

  Fly   525 CSNLQHLDVTGCSQVSSISPNPHMEPPRRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRR 589
            |.||..:.::||..|:.                     ||:|       .::..||:|..|.|..
  Rat   113 CPNLASVTLSGCGHVTD---------------------DCLA-------RLLLGCPRLRALRLEN 149

  Fly   590 CIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIA 654
            |.:||:..|..|                          |..|.||:...|..|..||.|||..:.
  Rat   150 CARVTNRTLAAV--------------------------AAHGRALQTFHVDFCRNVSAAGLLRLR 188

  Fly   655 RRCYKLRYLNARGCEAVSDDSITVLARSCPRLRA 688
            ..|..| .|:|       :.|..::....||.||
  Rat   189 AACPNL-ILSA-------EHSAAMIPDQPPRARA 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	12/49 (24%)
		leucine-rich repeat	441..460	CDD:275381	3/24 (13%)
		AMN1	<451..595	CDD:187754	30/145 (21%)
		leucine-rich repeat	476..501	CDD:275381	8/26 (31%)
		leucine-rich repeat	502..521	CDD:275381	3/18 (17%)
		leucine-rich repeat	528..555	CDD:275381	4/26 (15%)
		leucine-rich repeat	556..581	CDD:275381	4/24 (17%)
		AMN1	577..746	CDD:187754	30/112 (27%)
		leucine-rich repeat	582..607	CDD:275381	8/24 (33%)
		leucine-rich repeat	608..633	CDD:275381	2/24 (8%)
		leucine-rich repeat	634..659	CDD:275381	9/24 (38%)
		leucine-rich repeat	660..685	CDD:275381	4/24 (17%)
		leucine-rich repeat	686..710	CDD:275381	2/3 (67%)
		leucine-rich repeat	711..735	CDD:275381
		leucine-rich repeat	737..761	CDD:275381
Fbxl22	NP_001102239.1	F-box-like	3..43	CDD:403981	10/37 (27%)
		AMN1	44..>191	CDD:187754	45/222 (20%)
		leucine-rich repeat	116..141	CDD:275381	8/52 (15%)
		leucine-rich repeat	142..167	CDD:275381	10/50 (20%)
		leucine-rich repeat	168..193	CDD:275381	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810