DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and CG9003

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	178/704 - (25%)
Similarity:	287/704 - (40%)	Gaps:	175/704 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 GNSADTEDSSDNNAGGGGAGSGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLY 233
            |.::.|...|.::..|||:.|.||||||         |:..:...:||              |..
  Fly    14 GGTSGTGTGSSSSNNGGGSSSNSGGAGG---------SIELLCPPSGS--------------SSI 55

  Fly   234 LGNALRTLPLGAEASQFQNERYYLE---DYSSGSGNERLPE-----------RLH--------HP 276
            .|:|..:...||..|..|.....:.   |.|:.:||...|.           |.|        |.
  Fly    56 SGSASFSSNSGASGSSSQTHSTAVSSATDRSNNNGNNHNPSLQLNGNGGSNTRQHSSGSNSRQHS 120

  Fly   277 RTSS----------PSETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCN-------LGRFSPSLDQ 324
            .:||          ||.:|.|      ||:|:|:.||  .::..|.|:       .|..:|.::.
  Fly   121 SSSSNSNSSNISPPPSSSSSS------RSNNNNNNHS--SNIISGFCSTIWRSATFGSATPVINP 177

  Fly   325 GYATLVSPSPTGHHSSGGAGNVTNSTTASGAGI------MASSTPTTTPRRGASSNGLGGGAASA 383
              ...||.:|....||..:.::::|||.. .|:      ||.|....:  ...|...||.....
  Fly   178 --LPAVSINPKIMESSSDSCSLSSSTTPD-VGLADQQRNMAGSAQDQS--EDQSQTFLGATELD- 236

  Fly   384 IGPPPWNRKGPFRCGPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLA-----WRPI---- 439
                          ..|..:||.|.::|:||:||...||..|:||:.:..||     |:.|
  Fly   237 --------------DELIKQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLFD 287

  Fly   440 -------------------LWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGC 485
                               ..|.:||||....||::::.:...         |..:|.:.|:|..
  Fly   288 FQRDIEGPVIENISQRCRGFLKSLSLRGCQSVGDQSVRTLANH---------CHNIEHLDLSDCK 343

  Fly   486 RISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEP 550
            :|:|...|.::|.|.:||.:.|.:|.:||:.:|......|.||..::|:.|..:|...    :|.
  Fly   344 KITDISTQSISRYCSKLTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENG----VEA 404

  Fly   551 PRR--LLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSV 613
            ..|  :.|:......|..|:|..:..:.|.||.|:.|.|..|..:||:.::.:.:.|..|::|.|
  Fly   405 LARGCVKLRKFSSKGCKQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCV 469

  Fly   614 SDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITV 678
            |.|.::||..|..|::....|..|.|:.|...:|.|.:.:.|.|..|..::...|..::|.::..
  Fly   470 SKCADLTDLTLLSLSQHNHLLNTLEVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAH 534

  Fly   679 LARSCPRLRALDIGKCD-VSDAGLRALAE-SCPN--LKKLSLRSCDMITDRGVQCIAYYCRGLQQ 739
            ||..||.|..|.:..|: ::|.|:|.|.. ||..  |..|.|.:|.:||||.::.:. .|..||:
  Fly   535 LATGCPSLEKLTLSHCELITDDGIRHLTTGSCAAEILSVLELDNCPLITDRTLEHLV-SCHNLQR 598

  Fly   740 LNIQDC-----------------------------PVSIEGYRAVKKYCKRCII 764
            :.:.||                             |....|:|  .:||:.|.|
  Fly   599 IELFDCQLITRTAIRKLKNHLPNIKVHAYFAPGTPPAVTSGHR--PRYCRCCEI 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	19/73 (26%)
		leucine-rich repeat	441..460	CDD:275381	7/18 (39%)
		AMN1	<451..595	CDD:187754	37/145 (26%)
		leucine-rich repeat	476..501	CDD:275381	8/24 (33%)
		leucine-rich repeat	502..521	CDD:275381	7/18 (39%)
		leucine-rich repeat	528..555	CDD:275381	6/28 (21%)
		leucine-rich repeat	556..581	CDD:275381	6/24 (25%)
		AMN1	577..746	CDD:187754	56/201 (28%)
		leucine-rich repeat	582..607	CDD:275381	7/24 (29%)
		leucine-rich repeat	608..633	CDD:275381	9/24 (38%)
		leucine-rich repeat	634..659	CDD:275381	8/24 (33%)
		leucine-rich repeat	660..685	CDD:275381	6/24 (25%)
		leucine-rich repeat	686..710	CDD:275381	9/25 (36%)
		leucine-rich repeat	711..735	CDD:275381	8/23 (35%)
		leucine-rich repeat	737..761	CDD:275381	9/52 (17%)
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	17/44 (39%)
		leucine-rich repeat	280..307	CDD:275381	2/26 (8%)
		AMN1	<308..453	CDD:187754	44/157 (28%)
		leucine-rich repeat	308..327	CDD:275381	7/18 (39%)
		leucine-rich repeat	334..359	CDD:275381	8/24 (33%)
		leucine-rich repeat	360..385	CDD:275381	8/24 (33%)
		leucine-rich repeat	386..411	CDD:275381	6/28 (21%)
		AMN1	<409..586	CDD:187754	54/176 (31%)
		leucine-rich repeat	412..437	CDD:275381	6/24 (25%)
		leucine-rich repeat	438..463	CDD:275381	7/24 (29%)
		leucine-rich repeat	464..515	CDD:275381	17/50 (34%)
		leucine-rich repeat	516..541	CDD:275381	6/24 (25%)
		leucine-rich repeat	542..561	CDD:275381	6/18 (33%)
		leucine-rich repeat	571..595	CDD:275381	9/24 (38%)
		leucine-rich repeat	596..621	CDD:275381	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457921
Domainoid	1	1.000	61	1.000	Domainoid score	I6923
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46756
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.970