DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and Fbl6

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_610665.2	Gene:	Fbl6 / 36201	FlyBaseID:	FBgn0033609	Length:	720	Species:	Drosophila melanogaster

Alignment Length:	724	Identity:	150/724 - (20%)
Similarity:	232/724 - (32%)	Gaps:	220/724 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 SGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGAQ----YLLDKKMESLYLGNALRTLPLGAEASQ 249
            |...|...:......:.|..|.:........|.|    .||||:..:....|.|..    :..||
  Fly    15 SDDDGVKEKAEVSTAKDSAETAMEVEADDTGGQQPEQSELLDKEKSATVDINTLTP----STPSQ 75

  Fly   250 FQNERYYLEDYSSGSGNERLPERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCN 314
            ...:...:|..:||| ...:||.:..|   ..|||...:......:|.|        ..||
  Fly    76 TPPQLLAVETATSGS-TAVIPENILSP---PKSETQTDETNTATSTSCS--------PASD---- 124

  Fly   315 LGRFSPSLDQGYATLVSPSPTGHHSSGGAGNVTNSTTASG-------AGIMASSTPTTTPRRG-- 370
             |:.||:.||    ..|..|....:......|..|...||       :|...|...||:||..
  Fly   125 -GQRSPAADQ----QSSAPPPQVQAQATPAPVNGSVPKSGKPLSTALSGKKTSKAATTSPRASRC 184

  Fly   371 ------------ASSNGLG------------GGAASAIGPP------------------------ 387
                        .|.|.:|            |..|....||
  Fly   185 RKTKALPMYESEISDNKMGIRLCIKKSDAGEGAPAGVTSPPVAVPAATKTVRKRVRKPKQQDSDE 249

  Fly   388 ----PWNRKG-----------------------PFRCGPLFDRLPDEAVVRIFSWLDSCELC--- 422
                |..:||                       |........:||:|.:.|||......:.|
  Fly   250 AEYEPRKKKGGGGGSGGEKKVSTSPDAAEAAGDPVEQSVWAQKLPEEVLFRIFEHAVDTQGCLPT 314

  Fly   423 --NVARVCRRFEHLAWRPILWKVISLR---GEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLA 482
              .:.|||..:..::.||.||:.:.|.   .|....:..||......|     .||.::.    .
  Fly   315 LFRLGRVCSLWRQVSLRPTLWRTMDLTTWVKEKYRTELKLKWFVDNRC-----SACTDLN----V 370

  Fly   483 DGCRISDKG--LQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGC-----SQVS 540
            ...:|||..  |..|:..||.|..:.|......|:..|...:.....||.||::..     :..|
  Fly   371 SNWKISDINCFLAKLSSGCPNLAGITLSGWKGFTSDHLTYLVDNMHKLQRLDLSSINVEMNASKS 435

  Fly   541 SISPNPHMEPPRRLLLQYLDLTDCMAIDDMGLK-------------------IVVKNCPQLVYLY 586
            ::..|                :.|.|:..||.:                   |:..:||.|..|.
  Fly   436 AVGVN----------------SLCNALQTMGSRLTHLYLAHNRLAGIPQIVGILSTHCPNLTLLD 484

  Fly   587 L-------------------RRC-----IQVTD-------AGLKFV---PSFCVSLKELSVSDCL 617
            |                   |.|     ::||:       |.::.:   |.| ..|:||||:...
  Fly   485 LSNVTTQATSHGVLHIEKLQRGCQKLKVLRVTNSHITPSTASMQEIMDSPGF-PELEELSVAALT 548

  Fly   618 N----ITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSD--DSI 676
            :    |:|..|..:.|..:.|:.|.|..|.|::...|  |....:.:::|...||....|  ..:
  Fly   549 DESRIISDDHLQRILKSSSKLKLLDVRNCTRLTHESL--IRLPAWDIKHLFLSGCSVTRDMGSGL 611

  Fly   677 TVLA-RSCPRLRALDIGKCDVS---DAGLRALAESCPNLKKLSLRSC-DMITDRGVQCIAYYCRG 736
            .::| :....|..||:...::.   |..||||||...:.....|..| ..::|..|:.|...|:.
  Fly   612 ELIASKWAHSLIELDLAWANMQQPIDNALRALAEKGRDSPLAHLNLCGSSVSDEAVKEILTNCQN 676

  Fly   737 LQQLNIQDC 745
            :..:|:..|
  Fly   677 MSSINLASC 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	14/50 (28%)
		leucine-rich repeat	441..460	CDD:275381	5/21 (24%)
		AMN1	<451..595	CDD:187754	35/193 (18%)
		leucine-rich repeat	476..501	CDD:275381	6/26 (23%)
		leucine-rich repeat	502..521	CDD:275381	4/18 (22%)
		leucine-rich repeat	528..555	CDD:275381	6/31 (19%)
		leucine-rich repeat	556..581	CDD:275381	6/43 (14%)
		AMN1	577..746	CDD:187754	51/214 (24%)
		leucine-rich repeat	582..607	CDD:275381	10/58 (17%)
		leucine-rich repeat	608..633	CDD:275381	9/28 (32%)
		leucine-rich repeat	634..659	CDD:275381	7/24 (29%)
		leucine-rich repeat	660..685	CDD:275381	5/27 (19%)
		leucine-rich repeat	686..710	CDD:275381	10/26 (38%)
		leucine-rich repeat	711..735	CDD:275381	5/24 (21%)
		leucine-rich repeat	737..761	CDD:275381	2/9 (22%)
Fbl6	NP_610665.2	F-box-like	293..341	CDD:289689	14/47 (30%)
		leucine-rich repeat	365..391	CDD:275381	7/29 (24%)
		leucine-rich repeat	392..417	CDD:275381	4/24 (17%)
		leucine-rich repeat	418..445	CDD:275381	7/42 (17%)
		leucine-rich repeat	453..471	CDD:275381	0/17 (0%)
		leucine-rich repeat	480..509	CDD:275381	5/28 (18%)
		leucine-rich repeat	510..538	CDD:275381	5/28 (18%)
		leucine-rich repeat	539..579	CDD:275381	13/39 (33%)
		leucine-rich repeat	580..621	CDD:275381	7/42 (17%)
		leucine-rich repeat	622..649	CDD:275381	10/26 (38%)
		leucine-rich repeat	652..676	CDD:275381	6/23 (26%)
		leucine-rich repeat	677..698	CDD:275381	2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910