DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and CG8272

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster

Alignment Length:	464	Identity:	111/464 - (23%)
Similarity:	188/464 - (40%)	Gaps:	142/464 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 LPDEAVVRIFSWLDSCEL-----CNVA---RVCRRF-------EH-------LAWRPILWKVISL 446
            |.|..::|:.|::.|.|.     |::|   .:.|||       :|       |.::.|| .:::|
  Fly   178 LTDAILMRLTSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSSDHVLPSESVLTFKFIL-TILNL 241

  Fly   447 RGEHLNGDKTLKMI--FRQLCGQSCNGACP---EVERVMLADGCR-------------------- 486
            :      .:||:::  ...|.||:....|.   :::|:.|| |||
  Fly   242 Q------RRTLRVLNFSHTLIGQALLALCDLNLQLQRLYLA-GCRQLNCTTILNFLATQPQLCAL 299

  Fly   487 -------ISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSS--- 541
                   ::|:.|..|.:..|:|.||::..|:.|||...:. |.|...|:.||::.|..::|
  Fly   300 DLSATMCVNDENLAALVQTNPQLEHLKVNGCLSITNAGAIH-LAKLKCLKSLDISNCDNLTSSGI 363

  Fly   542 -----ISPNPHMEPPRRLLLQYLDL-TDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQ-VTDAGLK 599
                 ...||.::   .|.:.||.: .:|       :|.:..|...|..|:|..|:. .||..::
  Fly   364 IEGIASEENPVIQ---ELNVSYLQICEEC-------IKAIASNLRCLRSLHLNHCVNGATDEAIQ 418

  Fly   600 FVPSFCVSLKELSVSDCLNITDFGL-------YELAK--------------------------LG 631
            .|......|:|||:..|..:||..|       .|:::                          |.
  Fly   419 SVIGQLRWLRELSLEHCSGLTDAALTGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLA 483

  Fly   632 AALRYLSV-----AKCERVSDAGLKVIARRCYK-------------------LRYLNARGCEAVS 672
            .:|:.:.:     |:.|.|.||..|......|:                   ||.||.|||..:|
  Fly   484 GSLQSIKISLRSKAEDEIVRDARRKQAMLAAYEMNLIREDDFEGHNIQQLRGLRSLNLRGCNKIS 548

  Fly   673 DDSITVLARSCPRLRALDIGKC-DVSDAGLRALAESCPNLKKLSLRSCDMITDRGVQCIAYYCRG 736
            |.|:....:.. .||.|.:..| .:|..|:.|:|.|||::::|.|..|..|||:.:|.:......
  Fly   549 DVSLKYGLKHI-ELRRLMLSNCQQISLLGMEAMASSCPSIEELDLSDCYNITDKTIQVVTSKLPR 612

  Fly   737 LQQLNIQDC 745
            |:.|:|..|
  Fly   613 LKALHISGC 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	15/64 (23%)
		leucine-rich repeat	441..460	CDD:275381	3/18 (17%)
		AMN1	<451..595	CDD:187754	42/185 (23%)
		leucine-rich repeat	476..501	CDD:275381	9/51 (18%)
		leucine-rich repeat	502..521	CDD:275381	7/18 (39%)
		leucine-rich repeat	528..555	CDD:275381	7/34 (21%)
		leucine-rich repeat	556..581	CDD:275381	5/25 (20%)
		AMN1	577..746	CDD:187754	58/228 (25%)
		leucine-rich repeat	582..607	CDD:275381	7/25 (28%)
		leucine-rich repeat	608..633	CDD:275381	10/57 (18%)
		leucine-rich repeat	634..659	CDD:275381	7/29 (24%)
		leucine-rich repeat	660..685	CDD:275381	10/24 (42%)
		leucine-rich repeat	686..710	CDD:275381	10/24 (42%)
		leucine-rich repeat	711..735	CDD:275381	7/23 (30%)
		leucine-rich repeat	737..761	CDD:275381	4/9 (44%)
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	44/182 (24%)
		leucine-rich repeat	270..295	CDD:275381	6/25 (24%)
		leucine-rich repeat	296..319	CDD:275381	3/22 (14%)
		leucine-rich repeat	322..346	CDD:275381	9/24 (38%)
		leucine-rich repeat	347..399	CDD:275381	13/61 (21%)
		leucine-rich repeat	400..426	CDD:275381	7/25 (28%)
		leucine-rich repeat	427..535	CDD:275381	18/107 (17%)
		AMN1	515..>642	CDD:187754	33/108 (31%)
		leucine-rich repeat	536..560	CDD:275381	10/24 (42%)
		leucine-rich repeat	561..586	CDD:275381	10/24 (42%)
		leucine-rich repeat	587..612	CDD:275381	7/24 (29%)
		leucine-rich repeat	613..638	CDD:275381	4/9 (44%)
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689
		leucine-rich repeat	129..166	CDD:275381
		leucine-rich repeat	167..192	CDD:275381	4/13 (31%)
		leucine-rich repeat	193..244	CDD:275381	11/57 (19%)
		C2	<231..274	CDD:301316	10/49 (20%)
		leucine-rich repeat	246..269	CDD:275381	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457922
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740