DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and Fbxl12

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001273458.1	Gene:	Fbxl12 / 30843	MGIID:	1354738	Length:	349	Species:	Mus musculus

Alignment Length:	401	Identity:	87/401 - (21%)
Similarity:	148/401 - (36%)	Gaps:	108/401 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 PPPWNR-KGPFRCGPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLA-----WRPILWKVI 444
            |..|.: ||..|.|...  ||.:.::     |.....|   |||.|::.|.     ||.:...:.
Mouse    21 PSSWKKPKGSQRRGARL--LPSQTIL-----LPRNPGC---RVCHRWKRLVDDRWLWRHVDLTLY 75

  Fly   445 SLRGE---HLNGDKTLKMIFR-QLCGQSCNGA-CPEVERVMLADGCRISDKGLQLLTRRCPELTH 504
            ::|.:   ||........::. ::.|...:|: .|::...:           ::.|.::||.|..
Mouse    76 TMRPKVMWHLLRRYMASRLYSLRMGGYLFSGSQAPQLSPAL-----------MRALGQKCPNLKR 129

  Fly   505 LQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEPPRRLLLQYLDLTDCMAIDD 569
            |    |:.:.:.::|...:..|.|:.|::..| ::|.|......:|      ..|.|.:|:.:|.
Mouse   130 L----CLHVADLSMVPITSLPSTLRTLELHSC-EISMIWLQKEQDP------TVLPLLECIVLDR 183

  Fly   570 MGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAAL 634
                                           ||:|               .|..|..|.:. .||
Mouse   184 -------------------------------VPAF---------------RDEHLQGLTRF-RAL 201

  Fly   635 RYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIGKCDVSDA 699
            |.|.:....||::.||....:....|:.|...||...:|.::..::|   .||  |:.|..::..
Mouse   202 RSLVLGGTYRVTETGLDASLQELSYLQRLEVLGCTLSADSTLLAISR---HLR--DVRKIRLTVG 261

  Fly   700 GLRA----LAESCPNLKKL----SLRSCDMITDRGVQCIAYYCRGLQQLNIQDCPVSIEGYRAVK 756
            ||.|    ..|..|.|:.|    .|.:.||.|...:.........|:.|.:|.  :..||..|.|
Mouse   262 GLSAQGLVFLEGMPVLESLCFQGPLITPDMPTPTQIVSSCLTMPKLRVLEVQG--LGWEGQEAEK 324

  Fly   757 KYCK---RCII 764
            ..||   .||:
Mouse   325 ILCKGLPHCIV 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	11/50 (22%)
		leucine-rich repeat	441..460	CDD:275381	3/21 (14%)
		AMN1	<451..595	CDD:187754	22/145 (15%)
		leucine-rich repeat	476..501	CDD:275381	2/24 (8%)
		leucine-rich repeat	502..521	CDD:275381	4/18 (22%)
		leucine-rich repeat	528..555	CDD:275381	6/26 (23%)
		leucine-rich repeat	556..581	CDD:275381	4/24 (17%)
		AMN1	577..746	CDD:187754	38/176 (22%)
		leucine-rich repeat	582..607	CDD:275381	3/24 (13%)
		leucine-rich repeat	608..633	CDD:275381	3/24 (13%)
		leucine-rich repeat	634..659	CDD:275381	7/24 (29%)
		leucine-rich repeat	660..685	CDD:275381	6/24 (25%)
		leucine-rich repeat	686..710	CDD:275381	8/27 (30%)
		leucine-rich repeat	711..735	CDD:275381	6/27 (22%)
		leucine-rich repeat	737..761	CDD:275381	9/26 (35%)
Fbxl12	NP_001273458.1	F-box-like	<51..73	CDD:289689	8/24 (33%)
		leucine-rich repeat	127..148	CDD:275381	4/24 (17%)
		AMN1	144..>249	CDD:187754	31/161 (19%)
		leucine-rich repeat	149..175	CDD:275381	7/32 (22%)
		leucine-rich repeat	176..200	CDD:275381	8/70 (11%)
		leucine-rich repeat	201..226	CDD:275381	7/24 (29%)
		leucine-rich repeat	227..252	CDD:275381	8/29 (28%)
		leucine-rich repeat	253..276	CDD:275381	5/22 (23%)
		leucine-rich repeat	277..306	CDD:275381	6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810