DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and Kdm2b

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_011246510.1	Gene:	Kdm2b / 30841	MGIID:	1354737	Length:	1312	Species:	Mus musculus

Alignment Length:	744	Identity:	154/744 - (20%)
Similarity:	231/744 - (31%)	Gaps:	215/744 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ECPLAS-LGRNSNAVRDH----YHHPHPLSSSPLDPQAYKMMSRKSPNPG---LEVAEALASRSS 70
            |||..: .|:...|.:..    :.:...|..|.|..|.....:::...|.   .|..||...||.
Mouse   691 ECPKCNHAGKTGKAYKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSD 755

  Fly    71 TPPSDQAGASSTAAAAAVLHMVQQK--AATFELRGRHSRPTEQQTSYGAHSTASVGRHAKKSPEL 133
            ..|............:..:|:.:::  ....||.|| .|.:..|||.|:.|      |....|.|
Mouse   756 EHPKKVPADGILRRKSDDVHLRRKRKYEKPQELSGR-KRASSLQTSPGSSS------HLSPRPPL 813

  Fly   134 PAPASRNVAPVPQPRNFLT-LEHVLQ-------FGTQRPSWMHGN-------------SADTEDS 177
            .:..|      |..|:.|| .:..|:       |..:|.||.:..             ..:.||.
Mouse   814 GSSLS------PWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRLSLANKPLRRFKQEPEDD 872

  Fly   178 SDNNAGGGGAGSGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRTLP 242
            ...            .....|.:...|.|.||.    |....||:...:||...:.....|....
Mouse   873 LPE------------APPKTRESDQSRSSSPTA----GPSTEGAEGPEEKKKVKMRRKRRLVNKE 921

  Fly   243 LGAEASQFQNERYYLEDYSSGSGNERLPERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQS 307
            |..|.|:..|......:       ..|......|..|.|...:...:..|:..... |..|||
Mouse   922 LSKELSKELNHEIQKTE-------STLAHESQQPIKSEPESENDEPKRPLSHCERP-HRFSKG-- 976

  Fly   308 LSDGLCNLGRFSPSLDQGYATLVSPSPTGHHSSGGAGNVTNSTTASGAGIMASSTPTTTPRRGAS 372
                                  ::.:|.....|.|.|      ..|...:|:...|:.:|.:...
Mouse   977 ----------------------LNGTPRELRHSLGPG------LRSPPRVMSRPPPSASPPKCIQ 1013

  Fly   373 SNGLGGGAASAIGPPPWNRKGPFRCGPLFDRLP----------DEAVVRIFSWLDSCELCNVARV 427
            ..      ...|.|||        ..|..|.||          .|..:.:||:|...:||...||
Mouse  1014 ME------RHVIRPPP--------ISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHRDLCVCMRV 1064

  Fly   428 CRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCR------ 486
            ||.:........||..|.|                        ..|..:..:||:...|
Mouse  1065 CRTWNRWCCDKRLWTRIDL------------------------NRCKSITPLMLSGIIRRQPVSL 1105

  Fly   487 ------ISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPN 545
                  ||.|.|..|..|.|.|..|.|..|..|...||..  :.|..|:.|||.....:......
Mouse  1106 DLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCS--SSCPLLRTLDVQWVEGLKDAQMR 1168

  Fly   546 PHMEPPR-----------------RLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQV 593
            ..:.||.                 .|.|..||:|      |:.|::::::.|.|..|.|..|..:
Mouse  1169 DLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDIT------DVSLRLIIRHMPLLSKLQLSYCNHI 1227

  Fly   594 TDAGLKFVPSFCV----SLKELSVSDCLNITDFGLYELAKLG----AALRYLSVAKCERVSDAGL 650
            .|..:..:.:...    ||.|:::|||..:||..|....:.|    ..|||     |::|:
Mouse  1228 NDQSINLLTAVGTTTRDSLTEVNLSDCNKVTDLCLSFFKRCGNICHIDLRY-----CKQVT---- 1283

  Fly   651 KVIARRCYKLRYLNARGCEA-VSDDSITV 678
                          ..|||. :::.|::|
Mouse  1284 --------------KEGCEQFIAEMSVSV 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	16/55 (29%)
		leucine-rich repeat	441..460	CDD:275381	3/18 (17%)
		AMN1	<451..595	CDD:187754	37/172 (22%)
		leucine-rich repeat	476..501	CDD:275381	9/36 (25%)
		leucine-rich repeat	502..521	CDD:275381	7/18 (39%)
		leucine-rich repeat	528..555	CDD:275381	6/43 (14%)
		leucine-rich repeat	556..581	CDD:275381	6/24 (25%)
		AMN1	577..746	CDD:187754	26/111 (23%)
		leucine-rich repeat	582..607	CDD:275381	5/28 (18%)
		leucine-rich repeat	608..633	CDD:275381	9/28 (32%)
		leucine-rich repeat	634..659	CDD:275381	5/24 (21%)
		leucine-rich repeat	660..685	CDD:275381	5/20 (25%)
		leucine-rich repeat	686..710	CDD:275381
		leucine-rich repeat	711..735	CDD:275381
		leucine-rich repeat	737..761	CDD:275381
Kdm2b	XP_011246510.1	JmjC	151..226	CDD:214721
		cupin_like	198..297	CDD:389752
		JHD	303..>338	CDD:375347
		zf-CXXC	<588..624	CDD:366873
		PHD_KDM2B	634..695	CDD:277114	3/3 (100%)
		PTZ00449	<693..995	CDD:185628	68/368 (18%)
		F-box-like	1044..1082	CDD:372399	12/37 (32%)
		leucine-rich repeat	1053..1075	CDD:275381	7/21 (33%)
		leucine-rich repeat	1078..1102	CDD:275381	7/47 (15%)
		AMN1	1083..1283	CDD:187754	53/236 (22%)
		leucine-rich repeat	1103..1126	CDD:275381	6/22 (27%)
		leucine-rich repeat	1127..1150	CDD:275381	8/24 (33%)
		leucine-rich repeat	1151..1190	CDD:275381	6/38 (16%)
		leucine-rich repeat	1191..1215	CDD:275381	7/29 (24%)
		leucine-rich repeat	1216..1245	CDD:275381	5/28 (18%)
		leucine-rich repeat	1246..1270	CDD:275381	8/23 (35%)
		leucine-rich repeat	1271..1295	CDD:275381	8/46 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810