DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and Fbxl21

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_038951543.1	Gene:	Fbxl21 / 306750	RGDID:	1305555	Length:	460	Species:	Rattus norvegicus

Alignment Length:	446	Identity:	92/446 - (20%)
Similarity:	161/446 - (36%)	Gaps:	115/446 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 IMASSTPTTTPRRGASSNGLGGGAASAIGPPPWNRKGPFRCGPLFDRLPDEAVVRIFSWLDSCEL 421
            ::.||.....|:||..::.......||:  ..|.            .||...::|||.:|...:.
  Rat    38 VVHSSPAVKQPKRGLCTSLRQTQMLSAL--LDWG------------TLPHHVILRIFQYLPLVDR 88

  Fly   422 CNVARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCR 486
            ...:.|||.:..:...|.||:....   .||...|  ..|:        ...|::.:
  Rat    89 ARASSVCRSWNEVFHIPDLWRKFEF---ELNQSAT--SYFK--------STHPDLIQ-------- 132

  Fly   487 ISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEPP 551
                  |::.:....|.::..:  ||.:.::...|....|.|.:..:.....:|:..|: .|..|
  Rat   133 ------QIIKKHAAHLQYVSFK--VDSSTESAEAACHILSQLVNCSIQTLGLISTAKPS-FMNMP 188

  Fly   552 RRLLLQYLDLT------------DCMAIDDMGLKIVV-KNCPQLVYLYLRRCIQVTDAGLKFVPS 603
            :...:..|.:.            :...:||..|||:| .|...|..|.:..|..|:..|:..|..
  Rat   189 KSHFVSALTVVFVNSKSLSSIKIEDTPVDDPSLKILVANNSDTLRLLKMSSCPHVSSDGILCVAD 253

  Fly   604 FCVSLKELS-----VSDCL----------NITDFGLYELAKLGAALRYLSVAKCERVSDA----- 648
            .|..|:||:     :||.|          |:....:..:::....:::.|:.|..  .||
  Rat   254 HCQGLRELALNYYILSDELLLALSSETHVNLEHLRIDVVSENPGQIKFHSIKKPS--WDALVKHS 316

  Fly   649 -GLKVIARRCYKLRYLNARGCEAVSDD-----------------SITVLAR---SCPRLRALDIG 692
             |:.|:   .|...|      |...|.                 |.|:|.|   :||||  :::.
  Rat   317 PGVNVV---MYFFLY------EEEFDTFFKEETPVTHLYFGRSVSRTILGRIGLNCPRL--IELV 370

  Fly   693 KC----DVSDAGLRALAESCPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQD 744
            .|    ...|:.|..:||.|.||..|.|..|::.....|:.:....|.|.||::.:
  Rat   371 VCANGLQPLDSELIRIAEHCKNLTALGLSECEVSCSAFVEFVRLCGRRLTQLSLME 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	12/45 (27%)
		leucine-rich repeat	441..460	CDD:275381	4/18 (22%)
		AMN1	<451..595	CDD:187754	28/156 (18%)
		leucine-rich repeat	476..501	CDD:275381	1/24 (4%)
		leucine-rich repeat	502..521	CDD:275381	3/18 (17%)
		leucine-rich repeat	528..555	CDD:275381	5/26 (19%)
		leucine-rich repeat	556..581	CDD:275381	8/37 (22%)
		AMN1	577..746	CDD:187754	49/213 (23%)
		leucine-rich repeat	582..607	CDD:275381	7/24 (29%)
		leucine-rich repeat	608..633	CDD:275381	7/39 (18%)
		leucine-rich repeat	634..659	CDD:275381	6/30 (20%)
		leucine-rich repeat	660..685	CDD:275381	8/44 (18%)
		leucine-rich repeat	686..710	CDD:275381	7/27 (26%)
		leucine-rich repeat	711..735	CDD:275381	5/23 (22%)
		leucine-rich repeat	737..761	CDD:275381	3/8 (38%)
Fbxl21	XP_038951543.1	F-box-like	68..111	CDD:403981	13/54 (24%)
		leucine-rich repeat	206..231	CDD:275381	7/24 (29%)
		leucine-rich repeat	232..257	CDD:275381	7/24 (29%)
		leucine-rich repeat	258..283	CDD:275381	6/24 (25%)
		leucine-rich repeat	284..318	CDD:275381	4/35 (11%)
		leucine-rich repeat	329..365	CDD:275381	7/35 (20%)
		AMN1	<359..>424	CDD:187754	20/66 (30%)
		leucine-rich repeat	366..392	CDD:275381	7/27 (26%)
		leucine-rich repeat	393..418	CDD:275381	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820