DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and Kdm2b

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_038945396.1	Gene:	Kdm2b / 304495	RGDID:	1310217	Length:	1350	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	163/745 - (21%)
Similarity:	242/745 - (32%)	Gaps:	217/745 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ECPLAS-LGRNSNAVRDH----YHHPHPLSSSPLDPQAYKMMSRKSPNPG---LEVAEALASRSS 70
            |||..: .|:...|.:..    :.:...|..|.|..|.....:::...|.   .|..||...||.
  Rat   729 ECPKCNHAGKTGKAYKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSD 793

  Fly    71 TPPSDQAGASSTAAAAAVLHMVQQK--AATFELRGRHSRPTEQQTSYGAHSTASVGRHAKKSPEL 133
            ..|............:..:|:.:::  ....||..| .|.:..|||.|:.|      |....|.|
  Rat   794 EHPKKVPTDGILRRKSDDVHLRRKRKYEKPQELSAR-KRASTLQTSPGSSS------HLSPRPPL 851

  Fly   134 PAPASRNVAPVPQPRNFLT-LEHVLQFGTQ-------RPSWMHGN-------------SADTEDS 177
            .:..|      |..|:.|| .:..|:.|.:       |.||.:..             ..:.||.
  Rat   852 GSSLS------PWWRSSLTYFQQQLKPGKEDKLLRKKRRSWKNAEDRLSLANKPLRRFKQEPEDD 910

  Fly   178 SDNNAGGGGAGSGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRTLP 242
            ...            .....|.:...|.|.||.    |....||:...:|:...:.....|....
  Rat   911 LPE------------APPKTRESDQSRSSSPTA----GPSTEGAEGPEEKRKVKMRRKRRLPNKE 959

  Fly   243 LGAEASQFQNERYYLEDYSSGSGNERLPERLHHPRTSSP-SETSGSDRYLLNRSSNSNHLHSKGQ 306
            |..|.|:..|  :.::...|...:|.     |.|..|.| ||.....|.|    |:....|
  Rat   960 LSKELSKELN--HEIQKTESTLAHEN-----HQPIKSEPESENEEPKRPL----SHCERPH---- 1009

  Fly   307 SLSDGLCNLGRFSPSLDQGYATLVSPSPTGHHSSGGAGNVTNSTTASGAGIMASSTPTTTPRRGA 371
                      |||..|:.      :|....|  |.|.|      ..|...:::...|:|:|.:..
  Rat  1010 ----------RFSKGLNG------TPRELRH--SLGPG------LRSPPRVISRPPPSTSPPKCI 1050

  Fly   372 SSNGLGGGAASAIGPPPWNRKGPFRCGPLFDRLP----------DEAVVRIFSWLDSCELCNVAR 426
            ...      ...|.|||        ..|..|.||          .|..:.:||:|...:||...|
  Rat  1051 QME------RHVIRPPP--------ISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQDLCVCMR 1101

  Fly   427 VCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCR----- 486
            |||.:........||..|.|  .|                      |..:..:||:...|
  Rat  1102 VCRTWNRWCCDKRLWTRIDL--NH----------------------CKSITPLMLSGIIRRQPVS 1142

  Fly   487 -------ISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISP 544
                   ||.|.|..|..|.|.|..|.|..|..|...||..  :.|..|:.|||.....:.....
  Rat  1143 LDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCS--SSCPLLRTLDVQWVEGLKDAQM 1205

  Fly   545 NPHMEPPR-----------------RLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQ 592
            ...:.||.                 .|.|..||:|      |:.|::::::.|.|..|:|..|..
  Rat  1206 RDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDIT------DVSLRLIIRHMPLLSKLHLSYCNH 1264

  Fly   593 VTDAGLKFVPSFCV----SLKELSVSDCLNITDFGLYELAKLG----AALRYLSVAKCERVSDAG 649
            |||..:..:.:...    ||.|:::|||..:||..|....:.|    ..|||     |::|:
  Rat  1265 VTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRY-----CKQVT--- 1321

  Fly   650 LKVIARRCYKLRYLNARGCEA-VSDDSITV 678
                           ..|||. :::.|::|
  Rat  1322 ---------------KEGCEQFIAEMSVSV 1336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	16/55 (29%)
		leucine-rich repeat	441..460	CDD:275381	4/18 (22%)
		AMN1	<451..595	CDD:187754	38/172 (22%)
		leucine-rich repeat	476..501	CDD:275381	9/36 (25%)
		leucine-rich repeat	502..521	CDD:275381	7/18 (39%)
		leucine-rich repeat	528..555	CDD:275381	6/43 (14%)
		leucine-rich repeat	556..581	CDD:275381	6/24 (25%)
		AMN1	577..746	CDD:187754	28/111 (25%)
		leucine-rich repeat	582..607	CDD:275381	7/28 (25%)
		leucine-rich repeat	608..633	CDD:275381	9/28 (32%)
		leucine-rich repeat	634..659	CDD:275381	5/24 (21%)
		leucine-rich repeat	660..685	CDD:275381	5/20 (25%)
		leucine-rich repeat	686..710	CDD:275381
		leucine-rich repeat	711..735	CDD:275381
		leucine-rich repeat	737..761	CDD:275381
Kdm2b	XP_038945396.1	JmjC	151..226	CDD:214721
		cupin_RmlC-like	198..304	CDD:424065
		JHD	303..>338	CDD:407680
		CTD_KDM2B	476..584	CDD:412026
		zf-CXXC	<626..662	CDD:366873
		PHD_KDM2B	672..733	CDD:277114	3/3 (100%)
		PTZ00449	<731..967	CDD:185628	52/264 (20%)
		F-box-like	1082..1120	CDD:403981	12/37 (32%)
		leucine-rich repeat	1116..1140	CDD:275381	8/47 (17%)
		AMN1	1132..1321	CDD:187754	52/201 (26%)
		leucine-rich repeat	1141..1164	CDD:275381	6/22 (27%)
		leucine-rich repeat	1165..1188	CDD:275381	8/24 (33%)
		leucine-rich repeat	1189..1228	CDD:275381	6/38 (16%)
		leucine-rich repeat	1229..1253	CDD:275381	7/29 (24%)
		leucine-rich repeat	1254..1283	CDD:275381	7/28 (25%)
		leucine-rich repeat	1284..1308	CDD:275381	8/23 (35%)
		leucine-rich repeat	1309..1333	CDD:275381	8/46 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810