DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and Fbxo39

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001034107.1	Gene:	Fbxo39 / 303287	RGDID:	1311464	Length:	443	Species:	Rattus norvegicus

Alignment Length:	369	Identity:	76/369 - (20%)
Similarity:	126/369 - (34%)	Gaps:	123/369 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 LPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILW--KVISLRGEHLNGDKTLKMIFRQLCG 466
            |||..:.|:|.||...:....|.|||::..:.:...||  :.|:..|
  Rat    19 LPDVCLRRVFWWLGDRDRSRAALVCRKWNQIMYSADLWRYRTITFSG------------------ 65

  Fly   467 QSCNGACPEVERVMLADGCRISDKGLQLLTRRCPELTHLQLQTC----------VDITNQALVEA 521
                    ...||..::    .:..|..:.:....|.||:::..          ..:|.:.|:..
  Rat    66 --------RPSRVHASE----FESALWYVKKFGRYLEHLEIKFLNPYNAVLTKKFQVTMRGLLSC 118

  Fly   522 LTKCSN------LQHLDVTGCSQVSSISPNPHMEPPRRLLLQYLDLTDCMAIDDMGLKIVVKNCP 580
            |.|.:|      :|||::......:||         |..|::.|.    ..:..||        .
  Rat   119 LGKSNNRLRSLSIQHLELDRLVWRNSI---------RGSLIKSLS----FFLKKMG--------K 162

  Fly   581 QLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERV 645
            .|.:|.|:......:.|...:.|......| :|:..|||.||..:.||..|::....::|
  Rat   163 HLDHLSLKGARLTVEQGCHILNSLSYMRNE-NVASELNIEDFFSHHLAVYGSSQFNKAMA----- 221

  Fly   646 SDAGLKVIARRCYKLRYLNAR-GCEAVSDDSITVLA-RSCPRLRALDIGKCDVSDA------GL- 701
                      ..:.|.:|... .|  :||:.:..|: .:...||.::| ||.|.|.      |:
  Rat   222 ----------TFHNLTFLTLNYNC--ISDELLETLSENNAGTLRTMNI-KCHVHDPHGQVVWGMS 273

  Fly   702 -RALAESCPNLK-------------------------KLSLRSC 719
             ..||....|||                         .:|||||
  Rat   274 WAKLARQASNLKVNFFFERVMKYERLARILLQEIPVRSISLRSC 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	14/44 (32%)
		leucine-rich repeat	441..460	CDD:275381	3/20 (15%)
		AMN1	<451..595	CDD:187754	24/159 (15%)
		leucine-rich repeat	476..501	CDD:275381	3/24 (13%)
		leucine-rich repeat	502..521	CDD:275381	5/28 (18%)
		leucine-rich repeat	528..555	CDD:275381	6/26 (23%)
		leucine-rich repeat	556..581	CDD:275381	3/24 (13%)
		AMN1	577..746	CDD:187754	40/178 (22%)
		leucine-rich repeat	582..607	CDD:275381	5/24 (21%)
		leucine-rich repeat	608..633	CDD:275381	10/24 (42%)
		leucine-rich repeat	634..659	CDD:275381	1/24 (4%)
		leucine-rich repeat	660..685	CDD:275381	6/26 (23%)
		leucine-rich repeat	686..710	CDD:275381	10/31 (32%)
		leucine-rich repeat	711..735	CDD:275381	7/34 (21%)
		leucine-rich repeat	737..761	CDD:275381
Fbxo39	NP_001034107.1	F-box-like	16..57	CDD:403981	12/37 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900