DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and Fbxl4

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_766576.1	Gene:	Fbxl4 / 269514	MGIID:	2140367	Length:	621	Species:	Mus musculus

Alignment Length:	378	Identity:	104/378 - (27%)
Similarity:	163/378 - (43%)	Gaps:	71/378 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 AASAIGPPPWNRKGPFRCGPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVI 444
            :::|:|..|.|        ..||:||.|.:..|.:.|...:||.:|:.||........|
Mouse   267 SSAALGDGPHN--------GYFDKLPYELIQLILNHLSLPDLCRLAQTCRLLHQHCCDP------ 317

  Fly   445 SLRGEHLN--------GDKTLKMIFRQLCGQSCNGACPEVERVMLA-DGCR--ISDKGLQLLTRR 498
             |:..|||        .|.:|:.:         ...|..|:.:.|: .|.|  ||..|.....:.
Mouse   318 -LQYIHLNLQPYWARLDDTSLEFL---------QARCVLVQWLNLSWTGNRGFISVSGFSRFLKV 372

  Fly   499 C-PELTHLQLQTCVDITNQALVEALTK-CSNLQHLDVTGCSQVSSISPNPHMEPP---------- 551
            | .||..|:| :|....|...:|.::: |.|||.|:::.|.::          ||
Mouse   373 CGSELVRLEL-SCSHFLNDTCLEVISEMCPNLQDLNLSSCDKL----------PPQAFGHIAKLC 426

  Fly   552 --RRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGL--KFVPSFCVSLKELS 612
              :||:|..      ..::...|..::..|.:|.:|.|..|:.:.|..:  ..:.:.|.:|:.|.
Mouse   427 SLKRLVLYR------TKVEQTALLSILNFCAELQHLSLGSCVMIEDYDVIASMIGAKCKNLRTLD 485

  Fly   613 VSDCLNITDFGLYELAKLGAALRYLSVAKCERV-SDAGLKV-IARRCYKLRYLNARGCEAVSDDS 675
            :..|.|||:.|:.|||.....|..|.:..|..: |..|..| :||:...|:.|......:|.|..
Mouse   486 LWRCKNITENGIAELASGCVLLEELDLGWCPTLQSSTGCFVRLARQLPNLQKLFLTANRSVCDTD 550

  Fly   676 ITVLARSCPRLRALDI-GKCDVSDAGLRALAESCPNLKKLSLRSCDMITDRGV 727
            |..||.:|.||:.||| |...||.|.||.|.|||.:|..|.:..|..|.::.|
Mouse   551 IEELASNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNKAV 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	13/45 (29%)
		leucine-rich repeat	441..460	CDD:275381	6/26 (23%)
		AMN1	<451..595	CDD:187754	37/168 (22%)
		leucine-rich repeat	476..501	CDD:275381	8/28 (29%)
		leucine-rich repeat	502..521	CDD:275381	5/18 (28%)
		leucine-rich repeat	528..555	CDD:275381	7/38 (18%)
		leucine-rich repeat	556..581	CDD:275381	3/24 (13%)
		AMN1	577..746	CDD:187754	53/156 (34%)
		leucine-rich repeat	582..607	CDD:275381	6/26 (23%)
		leucine-rich repeat	608..633	CDD:275381	10/24 (42%)
		leucine-rich repeat	634..659	CDD:275381	8/26 (31%)
		leucine-rich repeat	660..685	CDD:275381	8/24 (33%)
		leucine-rich repeat	686..710	CDD:275381	14/24 (58%)
		leucine-rich repeat	711..735	CDD:275381	5/17 (29%)
		leucine-rich repeat	737..761	CDD:275381
Fbxl4	NP_766576.1	F-box-like	280..318	CDD:372399	13/44 (30%)
		leucine-rich repeat	295..317	CDD:275381	6/21 (29%)
		leucine-rich repeat	318..340	CDD:275381	6/21 (29%)
		leucine-rich repeat	347..376	CDD:275381	8/28 (29%)
		LRR 1	376..397		7/21 (33%)
		leucine-rich repeat	377..402	CDD:275381	7/25 (28%)
		AMN1	394..601	CDD:187754	65/222 (29%)
		LRR 2	402..421		7/28 (25%)
		leucine-rich repeat	403..427	CDD:275381	6/33 (18%)
		LRR 3	427..448		4/26 (15%)
		leucine-rich repeat	428..452	CDD:275381	5/29 (17%)
		LRR 4	452..474		5/21 (24%)
		leucine-rich repeat	453..480	CDD:275381	6/26 (23%)
		LRR 5	480..501		8/20 (40%)
		leucine-rich repeat	481..506	CDD:275381	10/24 (42%)
		LRR 6	504..524		4/19 (21%)
		leucine-rich repeat	507..534	CDD:275381	8/26 (31%)
		LRR 7	532..558		7/25 (28%)
		leucine-rich repeat	535..560	CDD:275381	8/24 (33%)
		LRR 8	559..583		12/23 (52%)
		leucine-rich repeat	561..586	CDD:275381	14/24 (58%)
		LRR 9	584..609		6/20 (30%)
		leucine-rich repeat	587..612	CDD:275381	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810