DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and FBXL3

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_036290.1	Gene:	FBXL3 / 26224	HGNCID:	13599	Length:	428	Species:	Homo sapiens

Alignment Length:	408	Identity:	83/408 - (20%)
Similarity:	142/408 - (34%)	Gaps:	119/408 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 LPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQS 468
            |..:.::::|.:|...:..:.::|||.:..:...|.||:....   .||...|..:
Human    39 LLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEF---ELNQPATSYL--------- 91

  Fly   469 CNGACPEVERVMLADGCRISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDV 533
             ....||:.:              |::.|....|.::..:  ||.:.::...|....|.|.:..:
Human    92 -KATHPELIK--------------QIIKRHSNHLQYVSFK--VDSSKESAEAACDILSQLVNCSL 139

  Fly   534 TGCSQVSSISPNPHMEPPRRLLLQYLDLT------------DCMAIDDMGLKIVV-KNCPQLVYL 585
            .....:|:..|: .|:.|:...:..|.:.            |...:||..||::| .|...|..|
Human   140 KTLGLISTARPS-FMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLL 203

  Fly   586 YLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGL 650
            .:..|..|:.||:..|...|..|:||:::          |.|.. ...|..||..|..|:....:
Human   204 KMSSCPHVSPAGILCVADQCHGLRELALN----------YHLLS-DELLLALSSEKHVRLEHLRI 257

  Fly   651 KVIARR-----------------------------------------CYKLRYLNARGCEAVSDD 674
            .|::..                                         .|::...:.....:||.|
Human   258 DVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKD 322

  Fly   675 SITVLARSCPRLRALDIGKCDVSDAGLRAL-------AESCPNLKKLSLRSCDMITDRGVQCIAY 732
            .:..:..:||||..|     .|...|||.|       ||.|.||..:.|..|:      |.|.|:
Human   323 VLGRVGMTCPRLVEL-----VVCANGLRPLDEELIRIAERCKNLSAIGLGECE------VSCSAF 376

  Fly   733 -----YCRG-LQQLNIQD 744
                 .|.| |.||:|.:
Human   377 VEFVKMCGGRLSQLSIME 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	9/42 (21%)
		leucine-rich repeat	441..460	CDD:275381	4/18 (22%)
		AMN1	<451..595	CDD:187754	29/156 (19%)
		leucine-rich repeat	476..501	CDD:275381	2/24 (8%)
		leucine-rich repeat	502..521	CDD:275381	3/18 (17%)
		leucine-rich repeat	528..555	CDD:275381	5/26 (19%)
		leucine-rich repeat	556..581	CDD:275381	8/37 (22%)
		AMN1	577..746	CDD:187754	50/222 (23%)
		leucine-rich repeat	582..607	CDD:275381	8/24 (33%)
		leucine-rich repeat	608..633	CDD:275381	5/24 (21%)
		leucine-rich repeat	634..659	CDD:275381	6/65 (9%)
		leucine-rich repeat	660..685	CDD:275381	4/24 (17%)
		leucine-rich repeat	686..710	CDD:275381	10/30 (33%)
		leucine-rich repeat	711..735	CDD:275381	6/28 (21%)
		leucine-rich repeat	737..761	CDD:275381	4/8 (50%)
FBXL3	NP_036290.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		F-box-like	36..77	CDD:403981	8/37 (22%)
		LRR 1	119..146		3/26 (12%)
		leucine-rich repeat	174..199	CDD:275381	7/24 (29%)
		LRR 2	181..207		8/25 (32%)
		leucine-rich repeat	200..225	CDD:275381	8/24 (33%)
		LRR 3	208..233		9/34 (26%)
		LRR 4	234..259		6/25 (24%)
		leucine-rich repeat	252..286	CDD:275381	1/33 (3%)
		leucine-rich repeat	287..333	CDD:275381	5/45 (11%)
		LRR 5	316..341		9/29 (31%)
		leucine-rich repeat	334..360	CDD:275381	10/30 (33%)
		LRR 6	343..368		10/24 (42%)
		leucine-rich repeat	361..383	CDD:275381	6/27 (22%)
		LRR 7	369..394		10/30 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820