Protein Alignment Fbxl7 and FBXL2

DIOPT Version :9

• Sequence 1: NP_650512.1
• Gene: Fbxl7 / 41935
• FlyBaseID: FBgn0038385
• Length: 772
• Species: Drosophila melanogaster
• Sequence 2: NP_001336245.1
• Gene: FBXL2 / 25827
• HGNCID: 13598
• Length: 454
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 119/457 - (26%)
• Similarity: 194/457 - (42%)
• Gaps: 102/457 - (22%)

  Fly   398 GPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFR 462
            |.:..:||.|.::||||:||...||..|::.:.:..||.....|:.|.|    .|....::....
Human     9 GLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDL----FNFQTDVEGRVV 69

  Fly   463 QLCGQSCNGACPEVERVMLADGC-RISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCS 526
            :...:.|.|..    |.:...|| .:.|..|:...:.|..:.||.|..|..||:.........||
Human    70 ENISKRCGGFL----RKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCS 130

  Fly   527 NLQHLDVTGCSQVSSISPNPHMEPPRRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCI 591
            .|:|||:|.|..:::.|.....|..|.  |:||:|:.|..|...|::.:|:.|..|..|.||.|.
Human   131 KLKHLDLTSCVSITNSSLKGISEGCRN--LEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCT 193

  Fly   592 QVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARR 656
            |:.|..||.:.::|..|..|::..|..|||.|:.::.:....|:.|.::.|..::||.|..:...
Human   194 QLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLN 258

  Fly   657 CYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIGKCD-VSDAGLRALAESCPNL--------- 711
            |.:|:.|.|..|..::|...|:|||:|..|..:|:.:|. ::|:.|..|:..||.|
Human   259 CPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALVSLSFS 323

  Fly   712 ---------------KKL-------SLRSCDMITDRGV-------------------QCIAY--- 732
                           |||       ||..|::|||.|:                   .|:..
Human   324 DIIHLLKMKEPSHHNKKLFGFSFCKSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDV 388

  Fly   733 ------YCRGLQQLNIQDC-----------------------------PVSIEGYRAVKKYCKRC 762
                  .||||::|.:.||                             |.::.|  :.::.|:.|
Human   389 ALEHLENCRGLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYFAPVTPPTAVAG--SGQRLCRCC 451

  Fly   763 II 764
            :|
Human   452 VI 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	16/45 (36%)
		leucine-rich repeat	441..460	CDD:275381	4/18 (22%)
		AMN1	<451..595	CDD:187754	41/144 (28%)
		leucine-rich repeat	476..501	CDD:275381	6/25 (24%)
		leucine-rich repeat	502..521	CDD:275381	6/18 (33%)
		leucine-rich repeat	528..555	CDD:275381	9/26 (35%)
		leucine-rich repeat	556..581	CDD:275381	9/24 (38%)
		AMN1	577..746	CDD:187754	62/257 (24%)
		leucine-rich repeat	582..607	CDD:275381	10/24 (42%)
		leucine-rich repeat	608..633	CDD:275381	7/24 (29%)
		leucine-rich repeat	634..659	CDD:275381	7/24 (29%)
		leucine-rich repeat	660..685	CDD:275381	10/24 (42%)
		leucine-rich repeat	686..710	CDD:275381	7/24 (29%)
		leucine-rich repeat	711..735	CDD:275381	12/82 (15%)
		leucine-rich repeat	737..761	CDD:275381	7/52 (13%)
FBXL2	NP_001336245.1	F-box-like	15..56	CDD:315592	15/40 (38%)
		leucine-rich repeat	52..79	CDD:275381	5/30 (17%)
		AMN1	<76..223	CDD:332986	48/152 (32%)
		leucine-rich repeat	80..99	CDD:275381	5/22 (23%)
		leucine-rich repeat	106..131	CDD:275381	7/24 (29%)
		leucine-rich repeat	132..157	CDD:275381	8/24 (33%)
		leucine-rich repeat	158..183	CDD:275381	9/24 (38%)
		AMN1	168..398	CDD:332986	59/229 (26%)
		leucine-rich repeat	184..209	CDD:275381	10/24 (42%)
		leucine-rich repeat	210..235	CDD:275381	7/24 (29%)
		leucine-rich repeat	236..261	CDD:275381	7/24 (29%)
		leucine-rich repeat	262..287	CDD:275381	10/24 (42%)
		leucine-rich repeat	288..313	CDD:275381	7/24 (29%)
		leucine-rich repeat	314..364	CDD:275381	11/49 (22%)
		leucine-rich repeat	374..393	CDD:275381	1/18 (6%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940