DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and pof2

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_596079.1	Gene:	pof2 / 2540355	PomBaseID:	SPBC25B2.11	Length:	463	Species:	Schizosaccharomyces pombe

Alignment Length:	481	Identity:	110/481 - (22%)
Similarity:	186/481 - (38%)	Gaps:	148/481 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 RLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWR----PILWKVISLRGE-HLNG-------DK 455
            |:|:|....|.|:|::.||...:.||     .:||    |.||:.:..:.| .||.       .|
pombe     2 RVPNEVCFNILSYLEADELRCKSTVC-----TSWRNFIIPTLWEKVVFQNEAQLNNFFDTLQYSK 61

  Fly   456 TLKMIFRQLCGQSCNGACPEVERVMLADGCRISDKGLQLLTRRCPELTHLQLQTCVDITNQALVE 520
            .:...||.|  :..|  |..|.:.       ::||.|.|:| ....::.|.|..|..|:...:.:
pombe    62 DVSYYFRYL--RKLN--CSRVRKF-------LTDKHLMLMT-LATGISRLNLSGCTRISEPLIGK 114

  Fly   521 AL--------TKCSNLQHLDVTGCSQVSSISPNPHMEPPRRLLLQYLDLTDCMAIDDMGLKIVVK 577
            .|        ...||:..|.......:|...||          |:.|::.:|..::|.|:..::|
pombe   115 LLYQNLNLVTINFSNIFSLPANILEYISDNCPN----------LKALNIGNCGLVEDTGMVQIIK 169

  Fly   578 NCPQLVYLYLRRCIQVTDAGLKFVP----------SFC------------VS----LKELS---- 612
            .||.|..|.:..|.::||..|:.:.          |.|            ||    |||||
pombe   170 RCPYLNRLIIPNCRKLTDVSLQILSEKEDLIELDISGCEGFHNADTLSRLVSRNRGLKELSMDGC 234

  Fly   613 -------------------------------------------------VSDCLNITDFGLYELA 628
                                                             :|.|:.:||..|..|.
pombe   235 TELSHFITFLNLNCELDAMRALSLNNLPDLKDSDIELITCKFSKLNSLFLSKCIGLTDSSLLSLT 299

  Fly   629 KLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIGK 693
            ||..:|..|.:..|..::|.|::.:.:.|..:.|::..||..:||.:::.:|: .|.|:.:.:.|
pombe   300 KLSQSLTTLHLGHCYEITDIGVQCLLKSCKNITYIDFGGCLRLSDIAVSAIAK-LPYLQRVGLVK 363

  Fly   694 C-DVSDAGLRALAES-CPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQDCPVSIEGYRAVK 756
            | .::|..:..|:.| ..||:::.|..|..:|.:.|..:.|.|:.|:.|       |:.|..::
pombe   364 CICLTDLSVILLSGSFSRNLERVHLSYCIGLTAKSVSYLMYNCKTLKHL-------SVTGINSI- 420

  Fly   757 KYC------KRCIIEHTNPG----FC 772
             .|      .|.|.:..||.    ||
pombe   421 -LCTELRSFSRPIPDGINPSQVPVFC 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	15/47 (32%)
		leucine-rich repeat	441..460	CDD:275381	5/26 (19%)
		AMN1	<451..595	CDD:187754	36/158 (23%)
		leucine-rich repeat	476..501	CDD:275381	6/24 (25%)
		leucine-rich repeat	502..521	CDD:275381	4/18 (22%)
		leucine-rich repeat	528..555	CDD:275381	4/26 (15%)
		leucine-rich repeat	556..581	CDD:275381	7/24 (29%)
		AMN1	577..746	CDD:187754	55/249 (22%)
		leucine-rich repeat	582..607	CDD:275381	8/46 (17%)
		leucine-rich repeat	608..633	CDD:275381	13/77 (17%)
		leucine-rich repeat	634..659	CDD:275381	6/24 (25%)
		leucine-rich repeat	660..685	CDD:275381	6/24 (25%)
		leucine-rich repeat	686..710	CDD:275381	6/25 (24%)
		leucine-rich repeat	711..735	CDD:275381	6/23 (26%)
		leucine-rich repeat	737..761	CDD:275381	5/29 (17%)
pof2	NP_596079.1	F-box-like	2..45	CDD:289689	15/47 (32%)
		leucine-rich repeat	96..121	CDD:275381	5/24 (21%)
		leucine-rich repeat	122..141	CDD:275381	3/18 (17%)
		AMN1	<143..292	CDD:187754	27/158 (17%)
		leucine-rich repeat	148..173	CDD:275381	7/24 (29%)
		leucine-rich repeat	174..225	CDD:275381	10/50 (20%)
		leucine-rich repeat	226..278	CDD:275381	5/51 (10%)
		AMN1	<278..428	CDD:187754	40/159 (25%)
		leucine-rich repeat	279..304	CDD:275381	8/24 (33%)
		leucine-rich repeat	305..330	CDD:275381	6/24 (25%)
		leucine-rich repeat	331..355	CDD:275381	6/24 (25%)
		leucine-rich repeat	356..382	CDD:275381	6/25 (24%)
		leucine-rich repeat	383..408	CDD:275381	7/24 (29%)
		leucine-rich repeat	409..427	CDD:275381	5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47209
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840