DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and Lrrc29

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001355337.1	Gene:	Lrrc29 / 234684	MGIID:	2443262	Length:	621	Species:	Mus musculus

Alignment Length:	592	Identity:	140/592 - (23%)
Similarity:	219/592 - (36%)	Gaps:	183/592 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 FSPSLDQGYATLVSPSPTGHHSSGGAGNVTN-------STTASGA----GIMASSTPTTTPRRGA 371
            |.|..||..|:||  |.|.:.::..|...||       |:.:..|    |:...|..:.|...|:
Mouse    16 FLPLSDQKEASLV--SRTWYCAAQNALRETNVRYNIPVSSASLSAIKSLGLRGISCISLTNLDGS 78

  Fly   372 SSNG------------------LGGGA-------ASAIGPPPWNRKGPFRCGPLFD-----RLPD 406
            .::.                  ||||:       |..:|.|.........|..||.     ..|:
Mouse    79 PASHQVLQSVAYHLGPHLESLCLGGGSPTEASFLALILGCPVLRTLDLSGCNSLFTSGTLLAQPE 143

  Fly   407 EA-VVR--------------------IFSWLDSCELCNVARVCRRFEHLA------WRPILWKVI 444
            .| .||                    .|:.|.|| ..::.|:...:.||:      |..|..:|.
Mouse   144 TAQCVREALSGLRDLNLAGLRDLTDLSFNHLSSC-FPSLERLSLAYCHLSFELSPTWGSISPQVS 207

  Fly   445 SLRGEHLNGDKTLKMIFRQLCGQ------SCNGACPE------------VERVMLADGCR-ISDK 490
            |  ...|:....||.| ::..|.      |..|..||            :|.:.| ..|| :|.:
Mouse   208 S--PSQLSFHNLLKFI-KERAGTLRALDLSGTGLPPEALQALGQVTGLKLEELYL-HSCRDLSSE 268

  Fly   491 GLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDV--------TGCSQVSSISPNPH 547
            .:.:|.|:.|.||.|.|..|.|:|:.||:.......:|:||.:        .||:.:.::..
Mouse   269 AVTILCRQQPGLTSLDLSGCSDLTDGALLAVSRGLRHLRHLSLKKLQRLTDAGCAALGALRE--- 330

  Fly   548 MEPPRRLLLQYLDLTDCMAIDDMGLKIV---VKNCPQ-LVYLYLRRCIQVTDAG-LKFVPSFCVS 607
                    ||.||:.:|..:....|..|   |:..|: |..|.|..|..:.||. |..:|:...|
Mouse   331 --------LQSLDMAECCLVSGRELAQVLGSVRRAPRALTSLRLAYCSSLKDASVLSMIPALGPS 387

  Fly   608 LKELSVSDCLNIT--------------------------DFGLYELAK----------------- 629
            ||.|.:|.|:.:|                          |:||..|.:
Mouse   388 LKVLDLSSCMALTNQTMQAICTYLIHLSVLRLAWCKELQDWGLLGLKEPSDEPVLSPQLHQKVDN 452

  Fly   630 ------------------LGAALRYLSVAKCERVSDAGL-KVIARRCYKLRYLNARGCEAVSDDS 675
                              :..||:.|.:..|.:::||.| ||:  :..:||.|:.....|.:|..
Mouse   453 EAPDPQEPSSEPQGSSLLMLQALQELDLTACSKLTDASLAKVL--QFPQLRQLSLSLLPAFTDTG 515

  Fly   676 ITVLARSCPRLRALDIGKCD-VSDAGLRALAESCPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQ 739
            :..:||.||.|..|.:..|. :||.|....|...|.|:.|:|.||..:|::.:..|...|:.|:.
Mouse   516 LVAVARGCPSLERLTLSHCSHLSDEGWAQAARLWPRLQHLNLSSCSQLTEQTLDTIGQACKQLRV 580

  Fly   740 LNIQDCP 746
            |::..||
Mouse   581 LDVAMCP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	16/77 (21%)
		leucine-rich repeat	441..460	CDD:275381	5/18 (28%)
		AMN1	<451..595	CDD:187754	44/174 (25%)
		leucine-rich repeat	476..501	CDD:275381	7/25 (28%)
		leucine-rich repeat	502..521	CDD:275381	9/18 (50%)
		leucine-rich repeat	528..555	CDD:275381	5/34 (15%)
		leucine-rich repeat	556..581	CDD:275381	8/27 (30%)
		AMN1	577..746	CDD:187754	56/233 (24%)
		leucine-rich repeat	582..607	CDD:275381	8/25 (32%)
		leucine-rich repeat	608..633	CDD:275381	10/85 (12%)
		leucine-rich repeat	634..659	CDD:275381	8/25 (32%)
		leucine-rich repeat	660..685	CDD:275381	8/24 (33%)
		leucine-rich repeat	686..710	CDD:275381	7/24 (29%)
		leucine-rich repeat	711..735	CDD:275381	7/23 (30%)
		leucine-rich repeat	737..761	CDD:275381	4/10 (40%)
Lrrc29	NP_001355337.1	F-box-like	3..38	CDD:372399	9/23 (39%)
		leucine-rich repeat	70..83	CDD:275381	2/12 (17%)
		LRR_RI	<118..360	CDD:393385	59/257 (23%)
		leucine-rich repeat	121..154	CDD:275381	7/32 (22%)
		leucine-rich repeat	155..180	CDD:275381	4/25 (16%)
		leucine-rich repeat	181..227	CDD:275381	11/48 (23%)
		leucine-rich repeat	228..248	CDD:275381	4/19 (21%)
		AMN1	240..428	CDD:187754	48/199 (24%)
		leucine-rich repeat	254..277	CDD:275381	7/23 (30%)
		leucine-rich repeat	280..305	CDD:275381	9/24 (38%)
		leucine-rich repeat	306..360	CDD:275381	14/64 (22%)
		leucine-rich repeat	331..356	CDD:275381	8/24 (33%)
		leucine-rich repeat	361..387	CDD:275381	8/25 (32%)
		leucine-rich repeat	388..413	CDD:275381	6/24 (25%)
		leucine-rich repeat	414..474	CDD:275381	4/59 (7%)
		AMN1	<475..589	CDD:187754	37/115 (32%)
		leucine-rich repeat	475..525	CDD:275381	16/51 (31%)
		leucine-rich repeat	526..551	CDD:275381	7/24 (29%)
		leucine-rich repeat	552..577	CDD:275381	8/24 (33%)
		leucine-rich repeat	578..603	CDD:275381	4/10 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810