DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbxl7 and Fbxl19

DIOPT Version :9

Sequence 1:NP_650512.1 Gene:Fbxl7 / 41935 FlyBaseID:FBgn0038385 Length:772 Species:Drosophila melanogaster
Sequence 2:XP_036008913.1 Gene:Fbxl19 / 233902 MGIID:3039600 Length:696 Species:Mus musculus


Alignment Length:614 Identity:130/614 - (21%)
Similarity:192/614 - (31%) Gaps:184/614 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 GGAGSGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRTLPLGAEASQ 249
            |.....:|...|||||..|         ..|:...|...|.::......|......||.|.....
Mouse   154 GRTSKDAGEGPGRRRADNG---------EEGANLGGGWKLTEEPPPPPPLPRRKGPLPAGPTPDD 209

  Fly   250 F-----QNERYYLEDYSSGSGNERLPERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQSLS 309
            .     :.||        ..|||        |.|.......|.:|:|.....::..|...... |
Mouse   210 VPGPPKRKER--------EGGNE--------PPTPRKKVKGGRERHLKKVGGDACLLRGADPG-S 257

  Fly   310 DGLCNLGRFSPSLDQGYAT------------------------LVSPSPTGH------------- 337
            .||......:||  |.:::                        :.||||...             
Mouse   258 PGLLPPRVLNPS--QAFSSCHPGLPPENWEKPKPPIASAEGPAVPSPSPQREKLERFKRMCQLLE 320

  Fly   338 ---HSSGGAGNVTNSTTASGAGIMASSTPTTT-----PRRGASSN------------GLGGGAAS 382
               .:|..:.:..:.:.:||..:.....|...     |.||:|..            |.||...|
Mouse   321 RVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAIRPGTGGPLLS 385

  Fly   383 -AIGPPPWNRKGPFRCGPLFDR------------------------LPDEAVVRIFSWLDSCELC 422
             .:||.|..|.      |..:|                        ||..|.:|:|..|...|||
Mouse   386 WPLGPAPPPRP------PQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELC 444

  Fly   423 NVARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCRI 487
            ...||||.:....:...||..:.|...            :.|.....:|......|.:......:
Mouse   445 VCMRVCRTWSRWCYDKRLWPRMDLSRR------------KSLTPPMLSGVVRRQPRALDLSWTGV 497

  Fly   488 SDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHL----DVTGCSQVSSISPNPHM 548
            |.|.|..|..|...|..|.|..|..::..||..|......|..|    ||........:.|.|..
Mouse   498 SKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDT 562

  Fly   549 EPPR-----------RLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVP 602
            :|.:           .|.|..|:|||.      .|::::::.|||..|.|..|..|.|..:..:.
Mouse   563 KPGQTESRGRLQGVAELRLAGLELTDA------SLRLLLRHAPQLSALDLSHCAHVGDPSVHLLT 621

  Fly   603 SFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARG 667
            :....|:|                      .|.:|::|.|.|::|..|.:. |||.:||.|:.|.
Mouse   622 APTSPLRE----------------------TLVHLNLAGCHRLTDHCLPLF-RRCPRLRRLDLRS 663

  Fly   668 CEAVSDDSITVLARS-------CPRLRAL 689
            |..:|.::...||.:       ||..:.|
Mouse   664 CRQLSPEACARLAAAGPPGPFRCPEEKLL 692

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl7NP_650512.1 F-box-like 401..447 CDD:289689 16/69 (23%)
leucine-rich repeat 441..460 CDD:275381 2/18 (11%)
AMN1 <451..595 CDD:187754 36/158 (23%)
leucine-rich repeat 476..501 CDD:275381 6/24 (25%)
leucine-rich repeat 502..521 CDD:275381 6/18 (33%)
leucine-rich repeat 528..555 CDD:275381 7/41 (17%)
leucine-rich repeat 556..581 CDD:275381 6/24 (25%)
AMN1 577..746 CDD:187754 31/120 (26%)
leucine-rich repeat 582..607 CDD:275381 6/24 (25%)
leucine-rich repeat 608..633 CDD:275381 2/24 (8%)
leucine-rich repeat 634..659 CDD:275381 10/24 (42%)
leucine-rich repeat 660..685 CDD:275381 9/31 (29%)
leucine-rich repeat 686..710 CDD:275381 1/4 (25%)
leucine-rich repeat 711..735 CDD:275381
leucine-rich repeat 737..761 CDD:275381
Fbxl19XP_036008913.1 zf-CXXC <52..79 CDD:366873
PHD_FXL19 89..150 CDD:277115
F-box-like 426..467 CDD:403981 15/40 (38%)
AMN1 468..667 CDD:187754 55/239 (23%)
leucine-rich repeat 488..511 CDD:275381 6/22 (27%)
leucine-rich repeat 512..535 CDD:275381 7/22 (32%)
leucine-rich repeat 573..600 CDD:275381 7/32 (22%)
leucine-rich repeat 601..627 CDD:275381 6/25 (24%)
leucine-rich repeat 631..655 CDD:275381 10/24 (42%)
leucine-rich repeat 656..680 CDD:275381 8/23 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167843068
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.740

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